Multiple alignment program for amino acid or nucleotide sequences

Mac OS X version

Download

• mafft-7.490-signed.pkg (Should run on macOS 10.12 – 11.4; Universal 2 binary)
• mafft-7.526-signed.pkg?jun6 (Should run on macOS 10.12 – ; Universal 2 binary)
  

  This package runs natively on both Apple Silicon and Intel Macs. However, until June 2025, the installer could prompt users to install Rosetta 2, even though it was not required. The issue has since been resolved. If you encounter any problems during installation or execution, please let us know. New! (2025/Jun/6)

Installation

1. Open the .pkg file and follow the installer's instructions.

Usage

1. Copy an input file (example) into your 'Home' folder (Finder → PLACES → your_username).
2. Open a Terminal window (Finder → Applications → Utilities → Terminal).
3. Type

   % mafft input.txt > output.txt
   

   The full path name (/usr/local/bin/) may be necessary, if it is not in your command-search path.

   % /usr/local/bin/mafft input.txt > output.txt