1. =_numo_s_00000001_numo_e_HOMSA|gi|5729790|ref|NP_006556.1| transcriptional repre 2. =_numo_s_00000002_numo_e_PELSI|ENSPSIP00000003796 pep:novel scaffold:PelSin_1.0: 3. =_numo_s_00000003_numo_e_gi|171474905|gb|ACB47393.1| CCCTC-binding factor [Pogon 4. =_numo_s_00000007_numo_e_gi|327281289|ref|XP_003225381.1| PREDICTED: transcripti 5. =_numo_s_00000008_numo_e_MONDO|ENSMODP00000007129 pep:novel chromosome:BROADO5:1 6. =_numo_s_00000009_numo_e_SARHA|ENSSHAP00000004296 pep:novel scaffold:DEVIL7.0:GL 7. =_numo_s_00000004_numo_e_gi|396094|emb|CAA80319.1| CTCF protein [Gallus gallus] 8. =_numo_s_00000006_numo_e_MELGA|ENSMGAP00000001773 pep:novel chromosome:UMD2:13:1 9. =_numo_s_00000011_numo_e_SARHA|ENSSHAP00000004295 pep:novel scaffold:DEVIL7.0:GL 10. =_numo_s_00000014_numo_e_gi|34785484|gb|AAH57697.1| Ctcf protein [Xenopus laevis 11. =_numo_s_00000016_numo_e_XENTR|ENSXETP00000062683 pep:known scaffold:JGI_4.2:GL1 12. =_numo_s_00000018_numo_e_LATCH|ENSLACP00000011174 pep:novel scaffold:LatCha1:JH1 13. =_numo_s_00000025_numo_e_ORENI|ENSONIP00000007230 pep:novel scaffold:Orenil1.0:G 14. =_numo_s_00000028_numo_e_TAKRU|ENSTRUP00000045998 pep:novel scaffold:FUGU4:scaff 15. =_numo_s_00000030_numo_e_TETNI|ENSTNIP00000012180 pep:novel chromosome:TETRAODON 16. =_numo_s_00000032_numo_e_GASAC|ENSGACP00000020939 pep:novel group:BROADS1:groupI 17. =_numo_s_00000034_numo_e_ORYLA|ENSORLP00000011017 pep:known chromosome:MEDAKA1:3 18. =_numo_s_00000035_numo_e_ORENI|ENSONIP00000005164 pep:novel scaffold:Orenil1.0:G 19. =_numo_s_00000037_numo_e_ORYLA|ENSORLP00000022986 pep:novel ultracontig:MEDAKA1: 20. =_numo_s_00000038_numo_e_GADMO|ENSGMOP00000006796 pep:novel genescaffold:gadMor1 21. =_numo_s_00000039_numo_e_GASAC|ENSGACP00000003270 pep:novel group:BROADS1:groupX 22. =_numo_s_00000019_numo_e_gi|126632718|emb|CAM56716.1| CCCTC-binding factor (zinc 23. =_numo_s_00000041_numo_e_SARHA|ENSSHAP00000015681 pep:novel scaffold:DEVIL7.0:GL 24. =_numo_s_00000043_numo_e_MONDO|ENSMODP00000020611 pep:novel chromosome:BROADO5:1 25. =_numo_s_00000046_numo_e_HOMSA|gi|29570785|ref|NP_542185.2| transcriptional repr 26. =_numo_s_00000047_numo_e_PELSI|ENSPSIP00000012493 pep:novel scaffold:PelSin_1.0: 27. =_numo_s_00000050_numo_e_SARHA|ENSSHAP00000001830 pep:novel scaffold:DEVIL7.0:GL 28. =_numo_s_00000040_numo_e_PETMA|ENSPMAP00000004689 pep:putative scaffold:Pmarinus 29. =_numo_s_00000055_numo_e_OIKDI|GSOIDT00001753001 30. =_numo_s_00000058_numo_e_STRPU|gi|72028083|ref|XP_797592.1| PREDICTED: uncharact 1 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ -----------------MEGDAVEAIVEESETFIKGKERKTYQRRRE----------------------------GGQEEDACHLPQNQTDGGEVV------------------------ -----------MEQGDKMEGEAIEAIGEESETFIKGKERKTYQRRRE----------------------------GGQEEDACHMPPNQADGAEVV------------------------ -----------------MEGEVVEAVGEESETFIKGKERKTYQRRRE----------------------------GGQEEDACPMPPNQADGSEVV------------------------ -----------------MEGEVVEAIGEESETFIKGKERKTYQRRRE----------------------------GGQEEDVCSMPPNQADGTEVV------------------------ -----------------MEGEAVEAIMEESETFIKGKERKTYQRRRE----------------------------GGQDEDACHISQTQADGSEVV------------------------ -----------------MEGEAVEAIMEESETFIKGKERKTYQRRRE----------------------------GGQDEDACHISQTQADGSEVV------------------------ -----------------MEGEAVEAIVEESETFIKGKERKTYQRRRE----------------------------GGQEDEACHIAPNQADGGEVV------------------------ -----------------MEGEAVEAIVEESETFIKGKERKTYQRRRE----------------------------GGQEDEACHIAPNQADGGEVV------------------------ -----------------MEGEAVEAIMEESETFIKGKERKTYQRRRE----------------------------GGQDEDACHISQTQADGSEVV------------------------ -----------------MEGEMAEDIVEDSETFMKRKETKTYQRRRE----------------------------GGVDEENCVIVQSQTDICEVP------------------------ -----------------MESEMAEAVVEDSETFMKRKETKTYQRRRE----------------------------GGVDEDNCVIVQSQTDISEVP------------------------ MQIYCTFLFLRERGREKMENEPSEVILEENETFSKGKERKTYQRRRE----------------------------GGQEEDNGAVIQNHPDGIEVVQDLQNQPDGTEEAQDLQNQSDGIE --------------------------------------------------------------------------------------EGGEALTQ-------------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ -----------------METGQATAL----------------------------------------------------ASDGKVLSEGGEALIQTG------------------------ -----------------MDGRPTDGV---GVVDVPTKEFPSIQAVHSQDAMVADLLQQAAEAG-------------GHGEGMAAATQSQQQLME------------------------GV ----------------------------------------------------------------------------------MVAGQTQQQLMDAG---------------------VGV ----------------------------------------------------------------------------------MEAVHNQQQLLE-------------------------- -----------------------------------------------------------------------------------MVAAAQHQLMEAA---------------------VGV -----------------MEGGPTEAVVEDAGDAFKAKECKTYQRRREDEEVGAELLQAAVIEQ--------------AQAEVEPVVEAQQQLVESV------------------------ ---------------------------------------------------------------------------------------RMGTEASASPEQFTKIKGTDVIQEKA-KENDVD ---------------------------------------------------------------------------------------RMGTEASASPEHFTKIKGTDLIQEKA-KESDVD ---------------------------------------------------------------------------------------MAATEISVLSEQFTKIKELELMPEKGLKEEEKD ---------------------------------------------------------------------------------------MMAAQDSHLPEPFTKIKGAERIWDRAREDDGGD ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ---------------MDENTDQPGSQTEEPVAPADQGEAEGTDAASMNVLETYLQNFNEELSSGPATAAGAVQQAAASTVAATEEDDTESPLAVHVEEVADAEEDVQLEEGAEGDNVAVV 121 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooooo -QDVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVAP---EAE------------------AAVDDTQIITLQVVN--------------------------ME -QEVSGGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVPQ---EAE------------------ATVDDTQIITLQVVN--------------------------ME -QDVNAGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVQQ---EAE------------------ATVDDTQIITLQVVN--------------------------ME -QDVNTGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GAVQQ---EAE------------------ATVDDTQIITLQVVN--------------------------ME -QEVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVPQ---EAD------------------ATVDDTQIITLQVVN--------------------------ME -QEVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVPQ---EAD------------------ATVDDTQIITLQVVN--------------------------ME -QDVNSGVQ-MVMMEHLDP-TLLQMKTEVME-----------------GAVPQ---ETE------------------ATVDDTQIITLQVVN--------------------------ME -QDVNSGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GAVPQ---ETE------------------ATVDDTQIITLQVVN--------------------------ME -QEVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVPQ---EAD------------------ATVDDTQIITLQVVN--------------------------ME -HDVNSNVQ-MVMMEQLDP-TLLQMKTEVME-----------------GMVSQ---EGD------------------PTVDDTQIITLQVVN--------------------------ME -HDVNSNVQ-MVMMEQLDP-TLLQMKTEVME-----------------GVVSQ---EGD------------------PTVDDTQIITLQVVN--------------------------ME AQDVNSNVQ-MVMMEQLDP-TLLQMKTEVME-----------------AGVNQ---EGE------------------ATVDDTQIITLQVVN--------------------------ME -GEVAGNME-MMVMDALDP-TLLQMKTEVLE-----------------GGGT----MTV------------------SGGDEGQIITLQVVN--------------------------ME --EVTGNME-MMVMDALDP-TLLQMKTEVLD-----------------GGGT----MTV------------------TGGDEGQIITLQVVN--------------------------ME --EVAGNME-MMVMDALDP-TLLQMKTEVLD-----------------GGGT----MTV------------------TGGDEGQIITLQVVN--------------------------ME -GEVVDDMG-MVVMDALDP-TLLQMKTEVLE-----------------GGGT----VTV------------------TGGDEGQIITLQVVN--------------------------ME QGDEAGTME-MMVMDALDP-ALLQMKTEVLE-----------------GGGT----VTV------------------TGGDEGQIITLQVVN--------------------------ME GVEGGTGVE-MMVMDSLDP-TLLQMKTEVIDAAVGGSSAAVGVVGGVPGSAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME AVDGGAGVD-MMVMDSLDP-TLLQMKTEVMDAAVGASSPSAAVVGGVAGAAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME --EGGGGVE-MMVMESLDP-ALLQMKTE----------------GGVAGGAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME GVDGGASVE-MMVMDSLDPIPLLQMKTEVIDSAVGGSSATLGVVGGVAGAAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME -VSVNSSVD-MMMMETLDP-ALLQMKTEVMEAAVGAPVA-------VAGAAHE---ATV------------------TTVDDTQIITLQVVN--------------------------ME KVSKLKERQ-SSCGLEVDC-SYGVLQAKIVE-------------------GELELA-PS------------------NEENEKHILTLQTVH--------------------------FA KVSRLKERQ-SSCGLEVDC-SYGVLQAKIVE-------------------GELELT-PQ------------------TQENEKHILTLQTVH--------------------------FA GVCREKDHR-SPSELEAER-TSGAFQDSVLE-------------------EEVELVLAP------------------SEESEKYILTLQTVH--------------------------FT RLPWVKERN-SICDPDVEV-LNGAPPAKALE-----------------GGRNLELS-PS------------------LIQSEKHLIMLQTVR--------------------------LK ------------------------------------------------EEGELDWH-PS------------------NEENERHLLALQMLP--------------------------FT --------------------------------------------------------------------------------EDTHIITLHPVS--------------------------LE ---MSQQYEEEPIMEE----------------------------------------------------------------EDGNTTTVQFIA--------------------------VA KQEIGEEEEMEEEVGEASQPAPDQATIDITHTLQLLANASANISNPNALQENQEGEMGTENTFMQQLDTSNLVDENGAKVDPSRIAGIQTVNGEQVVMVHNMEDGTSGIGQQQVLMVAMQ o o 241 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ oooooo ooooo EQ----PINIGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKEGLAESEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVSV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQS EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------DL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQA EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVAKEGLPEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-HGA-------YENEVSKEGLPEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-HGA-------YENEVSKEGLPEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQ--VPVAV---PMATTSVG----------------------EL-HAA-------FENDVSKEVLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQA EQ----PINLGELQLVQ--VPVAV---PMATTSVG----------------------EL-HAA-------FENEVSKEGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQA EQ----PISLGELQLVQVPVPVSV---PVTATTVG----------------------QL-QGT-------YENDVSKEGLQ-GEPVICHTLPLPE------GFQVVKVGANGEVETLEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVD----------------------GL-QAT-------YVETSAAN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVE----------------------GL-QAT-------YVDTSTTN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVE----------------------GL-QAT-------YVDASTTN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-TGAALGLGQLQLVQ------V---PVTRATVE----------------------GL-QAT-------YVDASTAN--KDADPVICHTLPLPE------GFQVVKVGANGEVETVEQ- EQ-AGAALGLGQLQLVQ------V---PVTTTTVE----------------------GL-QAT-------YVEASAAN--KDA--VICHTLPLPE------GFQVVKVGANGEVETVEQD EQ---AALGLGELQLVQ------V---PVSATTVE----------------------ALQQGN-------FVDTTAMP--KDGDPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ---AALGIGELQLVQ------V---PVSATTVE----------------------ALQQGT-------FVDASSIP--KDGDPVICHTLPLPE------GFQVLEDQKG--------- EQ---AALGLGELQLVQ------V---PVSASTVE----------------------ALQQGT-------FVDATAMP--KDGDPVICHTLPLPE------GFQVGKQ------------ EQ---AALGLGELQLVQ------V---PVSATTVE----------------------ALQQGT-------FVDTTAMP--KDGDPVICHTLPLPE------GFQVNKQTHS--------- EQ----QLGLGELQLVQVPVSA-V---PVTAATVE----------------------EL-QGT-------LVDATAMP--KDGEPVICHTLPLPE------GFQVVKVGANGEVETVEQD TD-ETDHQEMSQLTVQP---AEGM---HVMVQQGE----------------------SGLQSL-------LVLQQDIN-----VQAELNEIPHQN------LHQCVAISIQEEVFSLHEM TD-EMDHQEM---TVEP---AEGM---HVMVQQGE----------------------SGLQSL-------L----------------LNEIPHQN------LHHCVAISIQEEVFSLHEL SE-AVELQDMSLLSIQQ---QEGV---QVVVQQPG----------------------PGL-------------------------LWLEEGPRQS------LQQCVAISIQQELYSPQEM EG-EEDLQAVSQLNIQQ---QSGL---HMVVQRGA----------------------SVLQPL-------VVVQQGV-------------GAQQN------IPTGVAISLQDGVYTFHDM TD-ETG-QEMSQLAVQP---AEGM---HIMEPQGE----------------------SGLQSL-------LGWQQYIN-----VQPELNEMPHQD------LSRCVELNIPEEIFSLEEM ETGEGGGTSIGEITLVQVQADLTV---IIHNVKL-----------------------QLNSVL-------KIDVRRTL--LQGVP-ITHTLPLPE------GVQVVKVGPNGELE-VERA PEEHERMVREGELPETIQGADVQM---TIGGTESRPVRLIAVDSNGIPVTDPTILQAAAEQAG-------IMFVSKDENDHENQISIDEAMQLRN---------------EENQQVPGYQ DNGQLSSMDQGVAQIAFSGAPVNMVGDNIVYQTTQ-------NTQYVPVSHNGTTQLAMTQSGGEPGTEVYTILQTVDGAETTTITTPTTMVVSSGGVHHLGDEQTHVIATTSGDHPSYA o o 361 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooo ELP----------------------------PQEDPSWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEDPGWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKNKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKNKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQEEPGWQKDP-------DYVP---PMK-KSKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--DVNA ELQ----------------------------QQEEPGWQKDP-------DYVP---PIK-KTKKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--DVNA ELQPP-------------------------PPQEDPNWAKDP-------EFQP---PAK-K-KKTKKSKLR----Y-TEE-----------GKDVDVSVYDFEEEQQ--EGLLS--EVNA ELQ----------------------------PQDDPEWTKDP-------DYQPIT-AVR-KGKKGKKSRLR----Y-AEG-----------DRDMDVSVYDFEEEQQ--EGLLS--EVNA ELQAA----------------------------EDPDWSKDP-------DYQPIT-TVR-KGKKGKKSRLR----Y-GEG-----------DRDMDVSVYDFEEEQQ--EGLLS--EVNA ELQAAHEEL-----------------------QEDPDWSKDP-------DYQPIT-TVR-KGKKGKKSRLR----Y-GEG-----------DRDMDVSVYDFEEEQQ--EGLLS--EVNA ------------------------EVEATVPLEEDPEWSKDP-------DYQPIS-SLRNKGKKGKKSRLR----Y-GEG-----------NRDMDVSVYDFEEEQQ--EGMLS--EVNA ELQAAQEDLQGQEGEEVEEDEEAAEIVTSV-PQDDPEWTKDP-------DYQPIT-AVR-KGKKGKKSRLR----Y-AEG-----------DRDMDVSVYDFEEEQQ--EGLLS--EVNA EEG-----AETQPDEEEDEEEEPVQ-----PPNDDPNWAKDP-------DYQPPSGVVK-KIKKGKKSRLR----Y-AEG-----------DKDMDVSVYDFEEEQQ--EGLLS--EVNA --------FSRSVRAHQHSAGAPMQ-----PPNNDPSWAKDP-------DYQPPSGVVK-KVKKGKKSRLR----Y-AEG-----------DKDMDVSVYDFEEEQQ--EGLLS--EVNA ------------------------------VQNDDSAWSKDP-------DYQPPSAALK-KSKKGKKSRLR----Y-AEG-----------DKDMDVSVYDFEEEQQ--EGLLS--EVNA --------QSTFGEERKEPPAALLH-----PQNDDASWAKDP-------DYQPPHGAFK-KPKKGKKSRLR----Y-GEG-----------DKDMDVSVYDFEEEQQ--EGLLS--EVNA ELQ-----PQDDQPPHQEEEEEMAE-----PQNEDPAWSKDP-------DYTP---PVK-KVKKTKKSKLR----YNTEG-----------DKDMDVSVYDFEEEQQ--EGLLS--EVNA EVMEINVVEESVEVSSEEDKLTVNS-----PLDENTELIK----------------LCEEREFTDQKEEIF----T-FEKLREGEK-----EEIILLPANSEIEEHE--DVHSS--EQDI EVMEINVVEESVEISSEEDKLTVNP-----PLDENTESVKVE-------KNYEVPQLCEEREITDQKEGLF----T-FDKLREGEK-----EEIILLPANSEIEEHE--DIPSS--EQDT EVLQFHALEENVMVASEDSKLAVS-------LAETTGLIKLE-------EEQEKNQLLAER----TKEQLF----F-VETMSGDERS----DEIVLTVSNSNVEEQE--DQPTA--GQAD EVMQINVLQEKVQAKDEENKS----------MDKSPGMLLIK---------KLVPKNLKNSVKIDRTKDLH----A-VEEILSCTA-----KDDISVSLNEPKEQGE----QSV--VKKT EMIENYIRDESADFFNED-KWIFDF-----PFDE--ELLKDQDKGIYG-AEWEAQELCEEREYTDPKEEIV----N-FETPRDGEK-----EEIILLLANSEIEEHE--DIHSP--PQDL PMG----------------------------SQDERSKEKDP-------DYQL---PVKKPVRKGRKNKLR----Y-KQE-----------AADADISVYDFEEQEE--GRLVSSQDVGV DQ----------------------------PPADPYDYQAEP-----------------EYHDSEKGVPLR----NYTSQDVVYEEAPENGGIKQQENIYDYQDVPIQNEPKIDNHYKKS ELQ---------------------------PVSEDAAQQEEGALQMAAAEHEEVALIVQKPVKRKRGRPRKDEAAKMQTQIVIVREVVEG-EDGQDPSVYDFYAGED--DTAPV--AGGD 481 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooo EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKKGLG-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNIKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS EKVVGNMKPPKPTKIKKK--G-V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCS DEVSGTAK----NQAKSK--G-M-KRTFHCEICIFTSSRISSFNRHMKTHSDEKP--HMCHLCLKAFRTVTLLRNHVNTHTGTRPYKCS--DCDMAFVTSGELVRHRRYKHTHEKPFKCS DEVSGTAK----NQAKTK--D-V-KQTFHCEICIFTSSKISCFNRHMKTHSDEKP--HMCHLCLKAFRTVTLLRNHVNTHTGTRPYKCS--DCDMAFVTSGELVRHRRYKHTHEKPFKCT AEKAKSTK----NQRKTK--G-A-KGTFHCDVCMFTSSRMSSFNRHMKTHTSEKP--HLCHLCLKTFRTVTLLRNHVNTHTGTRPYKCN--DCNMAFVTSGELVRHRRYKHTHEKPFKCS DTLEAHTN----TQHRKK--G-E-KVTIHCDLCAFTSLRMSSLNRHMKTHSDEKP--HLCHLCLKAFRTVTLLRNHVNTHTGTRPYKCS--DCEMAFVTSGELARHRRYKHTLEKPFKCS DEVSQTAA----NQAETK--G-T-KWTFHCEICKFTSSKMSSLTRHMKTHTAEKP--HMCHLCPKAFRTGTLLRNHLNTHTGTRPYKCS--DCEMAFVTSGELGRHRRYKHTHEKRFKCS EKAIAP-KPPKPTRIKKK--G-A-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HCCHLCDRAFRTVTLLRNHVNTHTGTKPHKCM--ECDMAFVTSGELVRHRRYRHTHEKPFKCS QSNTQRTKYPGTIQVGAN--G-EKRKVYQCSECAFYSHRHSNLIRHMKIHTDERP--YKCHLCARAFRTNTLLRNHINTHLGVKPYKCPEANCEMAFVTSGELTRHRRYKHTHEKPFKCT EK----------SGIEVG--GAKKKTRYVVPKFDDGRLLDQVLNRAKKGGPGRRPKVHECHLCGRIFRTSTLLRNHENTHSGTKPYKCE--LCPKAFGTSGELGRHMKYMHTHEKPHKCP o * * o o* **** o *** ****** *** * o* ** * ** ***** ** o* ** ** **o 601 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ oooooooooooooooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooo ooooooooooooooo ooooooooooo ooooooooooo ooo MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSATVGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKK MCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKK MCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIEMGKK MCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIEMGKK MCDYCSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFLEKGKK MCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKYHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDLGGVHLRKQHSFIETGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDLGGVHLRKQHSFIETGKK MCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGRK MCKYASVEASKLKRHIRSHTGERPFHCCLCSYASKDTYKLKRHMRTHS---GEKPYECYVCHARFTQSGTMKIHILQKHSENVPKHQCPH--CSTVIARKSDL-RVHLRNLHSYKATEMK MCKYASVEASKLKRHIRSHTGERPFHCCLCNYASKDTYKLKRHMRTHS---GEKPYECYVCHARFTQSGTMKIHILQKHSENVPKHQCPH--CATVIARKSDL-RVHLRNLHSYKAAEMK MCKYASVEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS---GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPH--CATIIARKSDL-RVHMRNLHAYSAAELK VCKYSSVEASKLKRHIRSHTGERPYNCCLCSYASKDTYKLKRHMVTHS---GEKPYECYVCQARFTQSGTMKIHILQKHSENVPRYQCPH--CNAFIARKSDL-GVHLRNLHSYLAVAMK MCNYASVEASKLKRHIRSHTGERPFPCSFCNYASKDIFKLKRHMTSHS---GEKPYECSFCSARFSQSGTLKIHVLQKHSGNAPKHQCPH--CATLITRKSDL-RVHLRNLHSYSAAEMK MCDYASVEVSKLKRHIRSHTGERPFQCGLCSYASRDTYKLKRHMRTHS---GEKPYECHVCHARFTQSGTMKMHVLQKHTDNVPKYHCPH--CDAVIARKSDL-GVHLRKQHAVLERELR LCEYASVEISKLRRHFRSHTGERPFSCDICGKAFADSFHLKRHKFSHT---GEKPYECPHCKARFTQHGSLKMHVMQQHTKTAPKFECEREICHTMLGRKSDL-NVHLRKQHSYQEIPMQ LCDYLSVEASKIKRHMRSHTGEKPYKCTLCEYASTDNYKLKRHMRVHT---GERPFNCSQCDQSFSQKSSLKEH-EWKHVGNRPSHKCDH--CDTTFGRYADM-KTHVRKMHTAGE-PMI o* * *** **oo** ******o*o * * * * oo**** *o **o*oo* * *o* ooo* * * o * o * o o* o*o *o* *o 721 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooooooooooooooooo ooooo ooooooo oooooo ooooooooooooooooo ooooooooooooooo oooooooooo CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PTFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMVMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMVMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQGERNGFCIRI------------TVDTIKNFRVSVSSGAFDRQKQLLDMHFKRYHD-------PNFVPAAFVCSKC CRYCDTVFHERYALIQHQKSHKNEKRFKCDQ-------CEYACRQ-ERHMIMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PSFVPAAFVCSKC CRYCDTVFHERYALIQHQKSHKNEKRFKCDQ-------CEYACRQ-ERHMIMHKR------------THTGEKPYACSHCDKTF-RQKQLLDMHFKRYHD-------PSFVPAAFVCSKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKPYACSHCEKTF-RQKQLLDMHFKRYHD-------PTFVPATFVCTKC CRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKPFACSQCDKTF-RQKQLLDMHFKRYHD-------PSFIPTAFVCDKC CRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKPFACSQCEKTF-RQKQLLDMHFKRYHD-------PTFVPTAFVCSKC CRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKPFACSQCEKTF-RQKQLLDMHFKRYHD-------PNFVPTAFVCSKC CRYCDAVFHERYALIQHQKTHKNEKRFKCEQ-------CDYCCRQ-ERHMVMHKR------------THTGEKPFACSQCDKTF-RQKQLLDMHFKRYHD-------PNFVPTAFVCSKC CRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKPFACEQCEKTF-RQKQLLDMHFKRYHD-------PTFVPTAFVCTKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKPYACSQCEKTF-RQKQLLDMHFKRYHD-------PNFIPATFVCPKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKPFGCSQCEKTF-RQKQLLDMHFKRYHD-------PNFVPTAFVCPKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKPYACSQCEKTF-RQKQLLDMHFKRYHD-------PNFIPTSFVCPKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKPYACSQCEKTF-RQKQLLDMHFKRYHD-------PNFIPTAFVCPKC CRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMVMHKR------------THTGEKPYACSQCEKTF-RQKQLLDMHFRRYHD-------PNFVPTSFVCTKC CRYCPAVFHERYALIQHQKTHRNEKRFKCDD-------CNYACKQ-ERHMTVHKR------------THTGEKPFTCLSCNKCF-RQKQLLNVHFKKYHD-------KNFIPTVYECPKC CRYCTDVFHERYALIQHQKTHRNEKRFKCDD-------CSYACKQ-ERHMRVHKR------------THTGEKPFTCLSCNKCF-RQKQLLNVHFKKYHD-------KNFIPTVYECPKC CRYCSAVFHERYALIQHQKTHKNEKRFKCKH-------CSYACKQ-ERHMTAHIR------------THTGEKPFTCLSCNKCF-RQKQLLNAHFRKYHD-------ANFIPTVYKCSKC CSYCEAVFHERYALIQHKKTHRNEKRFKCDR-------CSYACKQ-ERHLIVHKR------------THTGEKPFTCVSCSKCF-RQKQLLTVHFRKHHD-------SNFKPTVYECPKC CRYCTAAFHERYALIQHQKTHRDEKRFKCDV-------CSYACKQ-AQHMTIHKR------------IHTGEKPFTCLSCNKSF-RQKQLLKVHFKKYHD-------ETSVPPVHECPKC CRYCRAIFHERYALMQHQRTHRNEKRFKCDQ-------CEYACKQ-ERHMIMHKR------------VHTGEKPFECTLCDKTF-RQKQLLDFHFKRYHD-------PSFVPTTYECSKC CRYCEEVFHDRWSLMQHQKTHRS-GRYRIDEDGNQIFDPDYDSEM-EDMEGGHGSGNLVYTEDGHVIGQDGSPNVIVQRVQHIDGQQGVPIEDHQQMQHDEHNMHAVEHQMDHSQEAPPI CKICENAFTDRFTYMQHVRGHRGEKIYKCGE-------CGYSAPQ-KRHLVIHMR------------VHTGERPYECEECHETF-KHKQTLINHQRSKHNLIQEADGTKKRKATDEITSP * * * o*oo o** oo*o oo * o o * *o 841 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooooooooo GKTFTRRNTMARHADNCAGPD------------------GVEGENGGE--------T----KKSKRGRKRKMRSKK-EDSSDS-ENA---E-------PDLDD--N------EDEEE--P GKTFTRRNTMARHADNCSGPD------------------GVEGENGGE--------P----KKGKRGRKRKMRSKK-EDSSDSEENA---E-------PDLDD--N------EDEEE--T GKTFTRRNTMARHADNCTGPD------------------GVEGENGGE--------P----KKGKRGRKRKMRSKK-EDSSDSEENA---E-------PELDN--N------EEEEE--T GKTFTRRNTMARHADNCTGPD------------------GVEGENGGE--------P----KKGKRGRKRKMRSKK-ENSSDSEENA---E-------PELYDIEE------EDEEE--T GKTFTRRNTMARHADNCTGLD------------------GIDGENGGE--------T----KKGKRGRKRKMRSKK-EESSDSEENA---E-------PDLDD--N------EDEEE--T GKTFTRRNTMARHADNCTGLD------------------GIDGENGGE--------T----KKGKRGRKRKMRSKK-EESSDSEENA---E-------PDLDD--N------EDEEE--T GKTFTRRNTMARHADNCSGLD------------------GGEGENGGE--------T----KKGKRGRKRKMRSKK-EDSSDSEENA---E-------PDLDD--N------EDEEE--T GKTFTRRNTMARHADNCSGLD------------------GGEGENGGE--------T----KKGKRGRKRKMRSKK-EDSSDSEENA---E-------PDLDD--N------EDEEE--T GKTFTRRNTMARHADNCTGLD------------------GIDGENGGE--------T----KKGKRGRKRKMRSKK-EESSDSEENA---E-------PDLDD--N------EDEEE--T GKTFTRRNTMSRHADSCTGPD------------------GTDGENGEE--------GEVIHKKGKRGRKRKMRSKK-EGSTDSEDNA---E-------PELDD--DDEDEDDDEEEE--T GKTFTRRNTMSRHADNCTGPD------------------GTDGENGGE--------SEVVHKKGKRGRKRKMRSKK-EGSSDSDHNN---E-------PFFQD--N------AEPEQ--T GKTFTRRNTMARHAENCTGPD------------------SVEGENGGE--------P----KKSKRGRKKKMRSKR-DDSSGSDENA---E-------PELDD--I------DEEEE--E SKTFTRRNTMLRHADNCTGDA------------------TLE-ENGTP--------PP---KKGRRGRKRKMQSRR-DDDDDDTVNI---E-------GELDE--------AEEEEDMLT SKTFTRRNTMLRHAENCMGDV------------------E-D-ENGTP--------TP---KKGRRGRKRKMQSRK-DDDDDDDDDT---E-------PDQED--------MDDEDEMLS SKTFTRRNTMLRHAENCMGDV------------------E-D-ENGTP--------TP---KKGRRGRKRKMQSRK-DDDDDDTGS----E-------PEPEE--------MDEEDEMLS NKTFTRRNTMLRHTENCSGEI------------------E-E-ENGTP--------AP---KKARRGRKRKMQTRR-DDDDTGSNAK---E-------DELDE--------VEEEEE-LS SKTFTRRNTMLRHAEGCTGEA------------------SGD-ENGTP--------TP---KKGRRGRKRKMQARE-KKPDKVDSDT---E-------GELDE--------IEEEDDLLT NKTFTRRNTMARHAENCSGEV------------------E-DAENGAT--------IP---KKGRRGRKRKMRSRRDDDDDSDEDHA---EQDDDEEEGEGEE--ESSLLQEEEDP---E SKTFTRRNTMARHAENCSGEV------------------D-DAENGAP--------TP---KKGRRGRKKKMRSRR-DEDDSDEDQL---E-PDDEDEAEEEE--EASLLLEEDEP---E SKTFTRRNTMARHAENCNGEI------------------D-DAENGTP--------TP---KRGRRGRKRKMRSRR-DEEEDSEDHA---D--------------PDLLLQEEEEQ---D SKTFTRRNTMVRHSENCNGEV------------------E-DAENGAP--------AP---KKGRRGRKRKMRSRR-DEEDSEDDNA---E--------FGEE--ETSLLQEEEEEEEPE GKTFTRRNTMARHAENCTGMD------------------SADGENGTP--------P----KRGRGGRKRKMRSRK-DDDDDDDSDEHGEP--------------DLDDIDEEDEDDLLD GKGFSRWNNMRKHSEHCEAVK------------------GKSI-------------PS---AKGRKNKKKKQKDPK-QDAKEEGRQT---------------RNFRSDKVVEQMPIEDTS GKGFSRWNNMRKHSELCEVIR------------------GKAV-------------QS---AKGRKTKKKKQKGPK-QDVKEEGK-------------------------FEQMPIEDIS GKGFSRWINLHRHSEKCGSGE------------------AKSA-------------AS---GKGRRTRKRKQTILK-EATKGQKEAA---------------KGWKEAANGDEAAAEEAS GKGYSRWNNMHKHAENCGLAR------------------AKVV-------------TR---HKGSKGKKKRWNSLK-QDVKQEGCSE-----------VSCGGLWESAGTVDLGSFQDVS GKGFSRLNNMRKHSEHCEVVR------------------GKAV-------------PS---A-----KEKDQKGPE-QGAREEVLIG-----------FQTAQGLRNYKVIEEMPIEDIS HRNFTRRSTMMKHFDMCDGEL------------------ESGEQNGK---------AR---RGRRRGRKRKMQSRK-HGSSSESDEMPTDE---------------------DEEEEELN HQGHHRQAHAEAKSERFEQEQQHDPFAFDDDQNMGNGEYMHAPQMGQTMAQPVE------------------------------------------------------------------ SKRITRRQRMQIQEEEETEEMVEPHTLTTADGNTIQVSMAQGGEGTVQLVQTSDGTMPVILTVGGDGQNVDEALQMMNGSLAAVQGHQDGEGQLMMAVPQGDGDNLHLEGQQASQQLQTS * o 961 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ AV-----EIEPEPEP--QPV-TPAPPPAKKRRGRPPGR-TNQPK------------QNQPTAIIQVEDQNTGAIENIIVEVKKEPD---------------AEPAEGEEEEAQPAAT--- AV-----EIEAEPEV--EPV-APTPPPAKKRRGRPPGK-ANQPK------------QPQPAAIIQVEDQNTGAIENIIVEVKKEPD---------------AETV-GEEEEAQPAAV--- AI-----EIEAEPEV--EPV-APVPPPAKKRRGRPPGK-SNQPK------------QTQPTTIIQVEDQNTDAIENIIVEVKKEPE---------------AETV-GATAGTQPAAA--- AV-----EIEAEPEIEAEPV-APPPPPAKKRRGRPPGK-ANQPK------------QPQPTAIIQVEDESTGTIENIIVEVKKEPE---------------AETV-GVAAGAQPEAV--- AV-----EIEAEPEV--QPV-TPAPPPAKKRRGRPPGK-SSQPK------------QTQPTAIIQVEDQNTGAIENIIVEVKKEPD---------------AETVEGEEEEPQSAVV--- AV-----EIEAEPEV--QPV-TPAPPPAKKRRGRPPGK-ASQPK------------QTQPTAIIQVEDQNTGAIENIIVEVKKEPD---------------AEAVEGEEEEPPSAVV--- AV-----EIEAEPEV--SAE-APAPPPSKKRRGRPPGKAATQTK------------QSQPAAIIQVEDQNTGEIENIIVEVKKEPD---------------AETVE-EEEEAQPAVV--- AV-----EIEAEPEV--EPE-APAPPPSKKRRGRPPGKAATQTK------------QSQPAAIIQVEDQNTGEIENIIVEVKKEPD---------------AETVE-EEEEAQPAVV--- AV-----EIEAEPEV--QPV-TPAPPPAKKRRGRPPGK-ASQPK------------QTQPTAIIQVEDQNTGAIENIIVEVKKEPD---------------AEAVEGEEEEPPSAVV--- PV-----EIEADPEP-EEPV-SPIPPPAKKRRGRPPGK-ANQAK--------------QNAAVIQVEDHNTRAIENIIVQVKKESD---------------LEAEVVVEAPVLTPAV--- PV-----EIEADPEP-EEPL-TPLPPPAKKRRGRPPGK-ANQAK--------------QNAAVIQVDDHSNRAIENIIVQVKKESD---------------LEAEGGVEAAVPTPAV--- AVVINDEEMEGGPEA------LPAPPPAKKKRGRPPGK-SNQAK------------STQTAAIIQVEDQNAGTIENIIVEVKKEPD---------------TEEEEGEVEQAQPVVV--- EI-----EVEQAPSV--VPIPAPVEPPVKRKRGRPPKSKPDSK-------------RIIAAAIIRVEDETTGEVDDIIV--KKEVG------------ADQDDD---GNEAAQEVVV--- EI-----EVEQAPPV--VPIPAPVEPPVKRKRGRPPKNKPAGEF------------QDQPAAIIRVEDEVTGEVDDIIV--KKEVG------------ADQDDQEICNEEAVEQVVV--- EI-----EVEQAPPV--VPIPAPVEPPVKRKRGRPPKNKPA------------------TAAIIRVEDEATGEVDDIIV--KKEVG------------ADQDDQEICSEEAVERCSC--- EL-----EVEQDPPV--VPIPAPVEPPVKRKRGRPPKNKPNIPKSDLK--------LLTAAAIIRVEDEVTGEVDDIIV--KKEVG------------VDRDDQEEATDGAVEE------ EI-----EVEQAAPV--IPIPAPIEPPVKRKRGRPPKNKPEVCPCFSGIS------NLSVAAIIHVEDEVQ-EVEELV---KKEVG---------------AEQVNCTDETTEQVITGGG SM-----ELDQAPAA--IPVPAPDEPPVKRKRGRPPKNAPK-PPTPSKSVRVATKTTASAAAIIQVEDESTGAVENIIV--KKEEGDASAATPLDQGVALTVEGVGLD-EGVETVEL--- SL-----ELDQAPAA--VPVPAPEEPPVKRKRGRPPKNAPK-VPAPSKPVRTPSK-TSSAAAVIQVEDESTGAV-DIIV--KKEEADGAAEAPLQGGVALAVEDAAMDAEGAETVEL--- AM-----ELDQAPAT--VPVPAPEEPPVKRKRGRPPKNAPKPAPTPTKSPRVAAKAAATAAAIIQVEDESTGAVENIIV--KKED-------PRAPGAGLAVEAVGLEAEEVEAVEV--- SM-----ELDQAPAA--IPVPAPDEPPVKRKRGRPPKNAPKPPPTPSRSARVAAKAAASAAALVQLEDESTGAVENITV--KKEDSQAPEATPAEQGAAPA-------AEGAETVEL--- EDQMG--LLDQAPPS--VPIPAPAEPPIKRKRGRPPKNAPKVSPTKSITK------TTTAAAIIQVEDESTGAIENIIV--KKEPE--------------------------GTDAVVAA IVNIEHHPNEIVPVVYGMAA-DV-EE---------------------------------------------------------------------------------------------- NVNIERHTNEIVPVGYGIAT-DVAEE---------------------------------------------------------------------------------------------- TTKGEQFPGEMFPVACRETTARVKEE---------------------------------------------------------------------------------------------- VVNTECCASEIVPVEYGIET-STPRE---------------------------------------------------------------------------------------------- IVNIENATVEMVPVVYGTTS--DVQE---------------------------------------------------------------------------------------------- EE-----SVEVADEE----VEEPEPPPMKRRRGRPPKAKPGRPA------KKVAGSDSVACGIIEIIPVTVGGPDGPDDDEEEE--------------EEEEEAAEGEEGAVETAADEG- ------------------------------------------------------------------------------------------------------------------------ DD--------------------------IADDSQPPELQQEGQVQEVSAPRESSSITQEQAAALQQQMVSQGIISEGSVIAAMEEDEDGTGDGTIYLFVEEQ------------------ 1081 .........+.........+.........+.........+.........+.........+.........+... -----------------------DAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDR-------------------------------- -----------------------EAPNGDLTPEMILSMMDRKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK -----------------------APPNGDLTPEMILSMMDR-------------------------------- -----------------------APPNGDLTPEMILSMMDR-------------------------------- ---------------------LRRRRNGDLTPEMILSMMDR-------------------------------- -----------EAVAAPEV--SEAPPNGDLTPEMILSMMDR-------------------------------- KPGAQSEELSQADAAAQEVQLSAAPSNGDLTPEMILSMMDR-------------------------------- -------------PVNEET--AAASANGDLTPEMILSMMDR-------------------------------- -------------ADGEET---VAAANGDLTPEMILSMMDR-------------------------------- -------------QGTEDEAGAAAAANGDLTPEMILSMMDR-------------------------------- -------------PVNEDTASAAAAANGDLTPEMILSMMDR-------------------------------- QPIIEEVEAVEADVETVQLTVPEAAPNGDLTPEMILSMMDR-------------------------------- -------------------------PKTEVTCEMILNMMDK-------------------------------- -------------------------QKTEVTCEMILNMMDK-------------------------------- -------------------------VDEGVTCEMLLNTMDK-------------------------------- -------------------------QKTEMTCEMILNMMDK-------------------------------- -------------------------PQTEITFEMILNMIEK-------------------------------- -------------------------PKNDITPEMILSMMDQ-------------------------------- ------------------------------------------------------------------------- -------------------------------------------------------------------------