1. =_numo_s_00000001_numo_e_HOMSA|gi|5729790|ref|NP_006556.1| transcriptional repre 2. =_numo_s_00000002_numo_e_PELSI|ENSPSIP00000003796 pep:novel scaffold:PelSin_1.0: 3. =_numo_s_00000003_numo_e_gi|171474905|gb|ACB47393.1| CCCTC-binding factor [Pogon 4. =_numo_s_00000007_numo_e_gi|327281289|ref|XP_003225381.1| PREDICTED: transcripti 5. =_numo_s_00000008_numo_e_MONDO|ENSMODP00000007129 pep:novel chromosome:BROADO5:1 6. =_numo_s_00000009_numo_e_SARHA|ENSSHAP00000004296 pep:novel scaffold:DEVIL7.0:GL 7. =_numo_s_00000010_numo_e_MACEU|ENSMEUP00000005228 pep:novel genescaffold:Meug_1. 8. =_numo_s_00000004_numo_e_gi|396094|emb|CAA80319.1| CTCF protein [Gallus gallus] 9. =_numo_s_00000005_numo_e_gi|326927215|ref|XP_003209788.1| PREDICTED: transcripti 10. =_numo_s_00000006_numo_e_MELGA|ENSMGAP00000001773 pep:novel chromosome:UMD2:13:1 11. =_numo_s_00000011_numo_e_SARHA|ENSSHAP00000004295 pep:novel scaffold:DEVIL7.0:GL 12. =_numo_s_00000012_numo_e_gi|224063911|ref|XP_002196108.1| PREDICTED: CCCTC-bindi 13. =_numo_s_00000014_numo_e_gi|34785484|gb|AAH57697.1| Ctcf protein [Xenopus laevis 14. =_numo_s_00000015_numo_e_gi|11878220|gb|AAG40852.1|AF305695_1 transcriptional re 15. =_numo_s_00000016_numo_e_XENTR|ENSXETP00000062683 pep:known scaffold:JGI_4.2:GL1 16. =_numo_s_00000017_numo_e_gi|170284950|gb|AAI61099.1| ctcf protein [Xenopus (Silu 17. =_numo_s_00000018_numo_e_LATCH|ENSLACP00000011174 pep:novel scaffold:LatCha1:JH1 18. =_numo_s_00000025_numo_e_ORENI|ENSONIP00000007230 pep:novel scaffold:Orenil1.0:G 19. =_numo_s_00000026_numo_e_gi|348509710|ref|XP_003442390.1| PREDICTED: transcripti 20. =_numo_s_00000027_numo_e_ORENI|ENSONIP00000007229 pep:novel scaffold:Orenil1.0:G 21. =_numo_s_00000028_numo_e_TAKRU|ENSTRUP00000045998 pep:novel scaffold:FUGU4:scaff 22. =_numo_s_00000029_numo_e_TAKRU|ENSTRUP00000045999 pep:novel scaffold:FUGU4:scaff 23. =_numo_s_00000030_numo_e_TETNI|ENSTNIP00000012180 pep:novel chromosome:TETRAODON 24. =_numo_s_00000031_numo_e_gi|47230373|emb|CAF99566.1| unnamed protein product [Te 25. =_numo_s_00000032_numo_e_GASAC|ENSGACP00000020939 pep:novel group:BROADS1:groupI 26. =_numo_s_00000033_numo_e_GASAC|ENSGACP00000020941 pep:novel group:BROADS1:groupI 27. =_numo_s_00000034_numo_e_ORYLA|ENSORLP00000011017 pep:known chromosome:MEDAKA1:3 28. =_numo_s_00000035_numo_e_ORENI|ENSONIP00000005164 pep:novel scaffold:Orenil1.0:G 29. =_numo_s_00000036_numo_e_gi|348523553|ref|XP_003449288.1| PREDICTED: transcripti 30. =_numo_s_00000037_numo_e_ORYLA|ENSORLP00000022986 pep:novel ultracontig:MEDAKA1: 31. =_numo_s_00000038_numo_e_GADMO|ENSGMOP00000006796 pep:novel genescaffold:gadMor1 32. =_numo_s_00000039_numo_e_GASAC|ENSGACP00000003270 pep:novel group:BROADS1:groupX 33. =_numo_s_00000019_numo_e_gi|126632718|emb|CAM56716.1| CCCTC-binding factor (zinc 34. =_numo_s_00000023_numo_e_gi|53734069|gb|AAH83236.1| Ctcf protein, partial [Danio 35. =_numo_s_00000024_numo_e_DANRE|ENSDARP00000059912 pep:known chromosome:Zv9:18:22 36. =_numo_s_00000041_numo_e_SARHA|ENSSHAP00000015681 pep:novel scaffold:DEVIL7.0:GL 37. =_numo_s_00000042_numo_e_SARHA|ENSSHAP00000015680 pep:novel scaffold:DEVIL7.0:GL 38. =_numo_s_00000043_numo_e_MONDO|ENSMODP00000020611 pep:novel chromosome:BROADO5:1 39. =_numo_s_00000044_numo_e_ORNAN|ENSOANP00000025255 pep:known ultracontig:OANA5:Ul 40. =_numo_s_00000046_numo_e_HOMSA|gi|29570785|ref|NP_542185.2| transcriptional repr 41. =_numo_s_00000047_numo_e_PELSI|ENSPSIP00000012493 pep:novel scaffold:PelSin_1.0: 42. =_numo_s_00000048_numo_e_gi|171474913|gb|ACB47397.1| brother of regulator of imp 43. =_numo_s_00000049_numo_e_ANOCA|ENSACAP00000016003 pep:novel scaffold:AnoCar2.0:G 44. =_numo_s_00000050_numo_e_SARHA|ENSSHAP00000001830 pep:novel scaffold:DEVIL7.0:GL 45. =_numo_s_00000040_numo_e_PETMA|ENSPMAP00000004689 pep:putative scaffold:Pmarinus 46. =_numo_s_00000054_numo_e_BRAFL|gi|260819198|ref|XP_002604924.1| hypothetical pro 47. =_numo_s_00000053_numo_e_MACEU|ENSMEUP00000007622 pep:novel genescaffold:Meug_1. 48. =_numo_s_00000055_numo_e_OIKDI|GSOIDT00001753001 49. =_numo_s_00000056_numo_e_CIOIN|ENSCINP00000013892 pep:known scaffold:KH:HT000097 50. =_numo_s_00000057_numo_e_CIOIN|ENSCINP00000031196 pep:known scaffold:KH:HT000097 51. =_numo_s_00000058_numo_e_STRPU|gi|72028083|ref|XP_797592.1| PREDICTED: uncharact 1 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ -----------------MEGDAVEAIVEESETFIKGKERKTYQRRRE----------------------------GGQEEDACHLPQNQTDGGEVV------------------------ -----------MEQGDKMEGEAIEAIGEESETFIKGKERKTYQRRRE----------------------------GGQEEDACHMPPNQADGAEVV------------------------ -----------------MEGEVVEAVGEESETFIKGKERKTYQRRRE----------------------------GGQEEDACPMPPNQADGSEVV------------------------ -----------------MEGEVVEAIGEESETFIKGKERKTYQRRRE----------------------------GGQEEDVCSMPPNQADGTEVV------------------------ -----------------MEGEAVEAIMEESETFIKGKERKTYQRRRE----------------------------GGQDEDACHISQTQADGSEVV------------------------ -----------------MEGEAVEAIMEESETFIKGKERKTYQRRRE----------------------------GGQDEDACHISQTQADGSEVV------------------------ -----------------MEGEAVEAVMEESETFIKGKERKTYQRRRE----------------------------GGQDEDACHISQTQADGSEVV------------------------ -----------------MEGEAVEAIVEESETFIKGKERKTYQRRRE----------------------------GGQEDEACHIAPNQADGGEVV------------------------ -----------------MEGEAVEAIVEESETFIKGKERKTYQRRRE----------------------------GGQEDEACHIAPNQADGGEVV------------------------ -----------------MEGEAVEAIVEESETFIKGKERKTYQRRRE----------------------------GGQEDEACHIAPNQADGGEVV------------------------ -----------------MEGEAVEAIMEESETFIKGKERKTYQRRRE----------------------------GGQDEDACHISQTQADGSEVV------------------------ -----------------MEGEAVDAIVEESETFIKGKERKTYQRRRE----------------------------GGQEDDACHIPPNQADGSEVV------------------------ -----------------MEGEMAEDIVEDSETFMKRKETKTYQRRRE----------------------------GGVDEENCVIVQSQTDICEVP------------------------ -----------------MEGEMAEDIVEDSETFMKRKETKTYQRRRE----------------------------GGVDEENCVIVQSQTDICEVP------------------------ -----------------MESEMAEAVVEDSETFMKRKETKTYQRRRE----------------------------GGVDEDNCVIVQSQTDISEVP------------------------ -----------------MESEMAEAVVEDSETFMKRKETKTYQRRRE----------------------------GGVDEDNCVIVQSQTDISEVP------------------------ MQIYCTFLFLRERGREKMENEPSEVILEENETFSKGKERKTYQRRRE----------------------------GGQEEDNGAVIQNHPDGIEVVQDLQNQPDGTEEAQDLQNQSDGIE --------------------------------------------------------------------------------------EGGEALTQ-------------------------- -----------------MISCQGNCLNFVSQAICLQGKKARKRAPTLTEADFIGFLKQPRICWPIAMEAEVVSMESAQATDGKVLPEGGEALTQ-------------------------- ------------------------------------------------------------------MEAEVVSMESAQATDGKVLPEGGEALTQ-------------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------MEDDVVSMETTQADGKVLPEGVDSLIQGS--------------------AIAQ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ -----------------METGQATAL----------------------------------------------------ASDGKVLSEGGEALIQTG------------------------ -----------------MDGRPTDGV---GVVDVPTKEFPSIQAVHSQDAMVADLLQQAAEAG-------------GHGEGMAAATQSQQQLME------------------------GV -----------------MDGRPTDGV---GVVDVPTKEFPSIQAVHSQDAMVADLLQQAAEAGGVVEGQAGVVVEQGHGEGMAAATQSQQQLME------------------------GV ----------------------------------------------------------------------------------MVAGQTQQQLMDAG---------------------VGV ----------------------------------------------------------------------------------MEAVHNQQQLLE-------------------------- -----------------------------------------------------------------------------------MVAAAQHQLMEAA---------------------VGV -----------------MEGGPTEAVVEDAGDAFKAKECKTYQRRREDEEVGAELLQAAVIEQ--------------AQAEVEPVVEAQQQLVESV------------------------ -----------------MEGGPTEAVVEDAGDAFKAKECKTYQRRREDEEVGAELLQAAVIEQ--------------AQAEVEPVVEAQQQLVESV------------------------ -----------------MEGGPTEAVVEDAGDAFKAKECKTYQRRREDEEVGAELLQAAVIEQ--------------AQAEVEPVVEAQQQLVESV------------------------ ---------------------------------------------------------------------------------------RMGTEASASPEQFTKIKGTDVIQEKA-KENDVD ------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------------------RMGTEASASPEHFTKIKGTDLIQEKA-KESDVD ------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------------------MAATEISVLSEQFTKIKELELMPEKGLKEEEKD ---------------------------------------------------------------------------------------MMAAQDSHLPEPFTKIKGAERIWDRAREDDGGD ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------TEASALAEQFTKRKGPDLIQEKDAESDGGL ------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------------MADDGKDSVEVTSQIESVNGTVAPPNDSIEPE ----------------------------------------------------------------------------------------MADDGKDSVEVTSQIESVNGTVAPPNDSIEPE ---------------MDENTDQPGSQTEEPVAPADQGEAEGTDAASMNVLETYLQNFNEELSSGPATAAGAVQQAAASTVAATEEDDTESPLAVHVEEVADAEEDVQLEEGAEGDNVAVV 121 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ -QDVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVAP---EAE------------------AAVDDTQIITLQVVN--------------------------ME -QEVSGGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVPQ---EAE------------------ATVDDTQIITLQVVN--------------------------ME -QDVNAGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVQQ---EAE------------------ATVDDTQIITLQVVN--------------------------ME -QDVNTGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GAVQQ---EAE------------------ATVDDTQIITLQVVN--------------------------ME -QEVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVPQ---EAD------------------ATVDDTQIITLQVVN--------------------------ME -QEVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVPQ---EAD------------------ATVDDTQIITLQVVN--------------------------ME -QEVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GAVPQ---EAD------------------ATVDDTQIITLQVVN--------------------------ME -QDVNSGVQ-MVMMEHLDP-TLLQMKTEVME-----------------GAVPQ---ETE------------------ATVDDTQIITLQVVN--------------------------ME -QDVNSGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GAVPQ---ETE------------------ATVDDTQIITLQVVN--------------------------ME -QDVNSGVQ-MVMMEQLDP-TLLQMKTEVME-----------------GAVPQ---ETE------------------ATVDDTQIITLQVVN--------------------------ME -QEVNSSVQ-MVMMEQLDP-TLLQMKTEVME-----------------GTVPQ---EAD------------------ATVDDTQIITLQVVN--------------------------ME -QDVSSGVQ-MVMMDQLDP-TLLQMKTEVME-----------------GAVSQ---ETE------------------ATVDDTQIITLQVVN--------------------------ME -HDVNSNVQ-MVMMEQLDP-TLLQMKTEVME-----------------GMVSQ---EGD------------------PTVDDTQIITLQVVN--------------------------ME -HDVNSNVQ-MVMMEQLDP-TLLQMKTEVME-----------------GMVSQ---EGD------------------PTVDDTQIITLQVVN--------------------------ME -HDVNSNVQ-MVMMEQLDP-TLLQMKTEVME-----------------GVVSQ---EGD------------------PTVDDTQIITLQVVN--------------------------ME -HDVNSNVQ-MVMMEQLDP-TLLQMKTEVME-----------------GVVSQ---EGD------------------PTVDDTQIITLQVVN--------------------------ME AQDVNSNVQ-MVMMEQLDP-TLLQMKTEVME-----------------AGVNQ---EGE------------------ATVDDTQIITLQVVN--------------------------ME -GEVAGNME-MMVMDALDP-TLLQMKTEVLE-----------------GGGT----MTV------------------SGGDEGQIITLQVVN--------------------------ME -GEVAGNME-MMVMDALDP-TLLQMKTEVLE-----------------GGGT----MTV------------------SGGDEGQIITLQVVN--------------------------ME -GEVAGNME-MMVMDALDP-TLLQMKTEVLE-----------------GGGT----MTV------------------SGGDEGQIITLQVVN--------------------------ME --EVTGNME-MMVMDALDP-TLLQMKTEVLD-----------------GGGT----MTV------------------TGGDEGQIITLQVVN--------------------------ME ---VTGNME-MMVMDALDP-TLLQMKTEVLD-----------------GGGT----MTV------------------TGGDEGQIITLQVVN--------------------------ME --EVAGNME-MMVMDALDP-TLLQMKTEVLD-----------------GGGT----MTV------------------TGGDEGQIITLQVVN--------------------------ME QAEVAGNME-MMVMDALDP-TLLQMKTEVLD-----------------GGGT----MTV------------------TGGDEGQIITLQVVN--------------------------ME -GEVVDDMG-MVVMDALDP-TLLQMKTEVLE-----------------GGGT----VTV------------------TGGDEGQIITLQVVN--------------------------ME ----------MVVMDALDP-TLLQMKTEVLE-----------------GGGT----VTV------------------TGGDEGQIITLQVVN--------------------------ME QGDEAGTME-MMVMDALDP-ALLQMKTEVLE-----------------GGGT----VTV------------------TGGDEGQIITLQVVN--------------------------ME GVEGGTGVE-MMVMDSLDP-TLLQMKTEVIDAAVGGSSAAVGVVGGVPGSAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME GVEGGTGVE-MMVMDSLDP-TLLQMKTEVIDAAVGGSSAAVGVVGGVPGSAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME AVDGGAGVD-MMVMDSLDP-TLLQMKTEVMDAAVGASSPSAAVVGGVAGAAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME --EGGGGVE-MMVMESLDP-ALLQMKTE----------------GGVAGGAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME GVDGGASVE-MMVMDSLDPIPLLQMKTEVIDSAVGGSSATLGVVGGVAGAAHQ---ATV------------------TTVDQTQIITLQVVN--------------------------ME -VSVNSSVD-MMMMETLDP-ALLQMKTEVMEAAVGAPVA-------VAGAAHE---ATV------------------TTVDDTQIITLQVVN--------------------------ME -VSVNSSVD-MMMMETLDP-ALLQMKTEVMEAAVGAPVA-------VAGAAHE---ATV------------------TTVDDTQIITLQVVN--------------------------ME -VSVNSSVD-MMMMETLDP-ALLQMKTEVMEAAVGAPVA-------VAGAAHE---ATV------------------TTVDDTQIITLQVVN--------------------------ME KVSKLKERQ-SSCGLEVDC-SYGVLQAKIVE-------------------GELELA-PS------------------NEENEKHILTLQTVH--------------------------FA --------------MEILK-SY-----------------------------------------------------------RRQI----------------------------------- KVSRLKERQ-SSCGLEVDC-SYGVLQAKIVE-------------------GELELT-PQ------------------TQENEKHILTLQTVH--------------------------FA ------------------------------------------------------------------------------------------------------------------------ GVCREKDHR-SPSELEAER-TSGAFQDSVLE-------------------EEVELVLAP------------------SEESEKYILTLQTVH--------------------------FT RLPWVKERN-SICDPDVEV-LNGAPPAKALE-----------------GGRNLELS-PS------------------LIQSEKHLIMLQTVR--------------------------LK ----------------------------------------------------------A------------------LGEGEKHLVLLKTVH--------------------------LK ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------EEGELDWH-PS------------------NEENERHLLALQMLP--------------------------FT --------------------------------------------------------------------------------EDTHIITLHPVS--------------------------LE ------------------------------------------------------------------------------------------------------------------------ SSRRGSGRG-LEVGC-----PYGVLQAKLVE---------------------GELQLVP------------------SQEGEKHVLTLQTVH--------------------------LA ---MSQQYEEEPIMEE----------------------------------------------------------------EDGNTTTVQFIA--------------------------VA ENEVSEKNE-EKIIEEVSNEAPAEAPV-----------------------------------------------------EDGTTTTVQFIA--------------------------VS ENEVSEKNE-EKIIEEVSNEAPAEAPV-----------------------------------------------------EDGTTTTVQFIA--------------------------VS KQEIGEEEEMEEEVGEASQPAPDQATIDITHTLQLLANASANISNPNALQENQEGEMGTENTFMQQLDTSNLVDENGAKVDPSRIAGIQTVNGEQVVMVHNMEDGTSGIGQQQVLMVAMQ 241 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ EQ----PINIGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKEGLAESEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVSV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQS EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------DL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQA EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVAKEGLPEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-HGA-------YENEVSKEGLPEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKEGLPEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-HGA-------YENEVSKEGLPEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQVPVPVTV---PVATTSVE----------------------EL-QGA-------YENEVSKGGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQG EQ----PINLGELQLVQ--VPVAV---PMATTSVG----------------------EL-HAA-------FENDVSKEVLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQA EQ----PINLGELQLVQ--VPVAV---PMATTSVG----------------------EL-HAA-------FENDVSKEVLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQA EQ----PINLGELQLVQ--VPVAV---PMATTSVG----------------------EL-HAA-------FENEVSKEGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQA EQ----PINLGELQLVQ--VPVAV---PMATTSVG----------------------EL-HAA-------FENEVSKEGLQEGEPMICHTLPLPE------GFQVVKVGANGEVETLEQA EQ----PISLGELQLVQVPVPVSV---PVTATTVG----------------------QL-QGT-------YENDVSKEGLQ-GEPVICHTLPLPE------GFQVVKVGANGEVETLEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVD----------------------GL-QAT-------YVETSAAN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVD----------------------GL-QAT-------YVETSAAN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVD----------------------GL-QAT-------YVETSAAN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVE----------------------GL-QAT-------YVDTSTTN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVE----------------------GL-QAT-------YVDTSTTN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVE----------------------GL-QAT-------YVDASTTN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVE----------------------GL-QAT-------YVDASTTN--KDAEPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-TGAALGLGQLQLVQ------V---PVTRATVE----------------------GL-QAT-------YVDASTAN--KDADPVICHTLPLPE------GFQVVKVGANGEVETVEQ- EQ-TGAALGLGQLQLVQ------V---PVTRATVE----------------------GL-QAT-------YVDASTAN--KDADPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ-AGAALGLGQLQLVQ------V---PVTTTTVE----------------------GL-QAT-------YVEASAAN--KDA--VICHTLPLPE------GFQVVKVGANGEVETVEQD EQ---AALGLGELQLVQ------V---PVSATTVE----------------------ALQQGN-------FVDTTAMP--KDGDPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ---AALGLGELQLVQ------V---PVSATTVE----------------------ALQQGN-------FVDTTAMP--KDGDPVICHTLPLPE------GFQVVKVGANGEVETVEQE EQ---AALGIGELQLVQ------V---PVSATTVE----------------------ALQQGT-------FVDASSIP--KDGDPVICHTLPLPE------GFQVLEDQKG--------- EQ---AALGLGELQLVQ------V---PVSASTVE----------------------ALQQGT-------FVDATAMP--KDGDPVICHTLPLPE------GFQVGKQ------------ EQ---AALGLGELQLVQ------V---PVSATTVE----------------------ALQQGT-------FVDTTAMP--KDGDPVICHTLPLPE------GFQVNKQTHS--------- EQ----QLGLGELQLVQVPVSA-V---PVTAATVE----------------------EL-QGT-------LVDATAMP--KDGEPVICHTLPLPE------GFQVVKVGANGEVETVEQD EQ----QLGLGELQLVQVPVSA-V---PVTAATVE----------------------EL-QGT-------LVDATAMP--KDGEPVICHTLPLPE------GFQVVKVGANGEVETVEQD EQ----QLGLGELQLVQVPVSA-V---PVTAATVE----------------------EL-QGT-------LVDATAMP--KDGEPVICHTLPLPE------GFQVVKVGANGEVETVEQD TD-ETDHQEMSQLTVQP---AEGM---HVMVQQGE----------------------SGLQSL-------LVLQQDIN-----VQAELNEIPHQN------LHQCVAISIQEEVFSLHEM RD-ETDHQEMSQLTVQP---AEGM---HVMVQQGE----------------------SGLQSL-------LVLQQDIN-----VQAELNEIPHQN------LHQCVAISIQEEVFSLHEM TD-EMDHQEM---TVEP---AEGM---HVMVQQGE----------------------SGLQSL-------L----------------LNEIPHQN------LHHCVAISIQEEVFSLHEL ------------------------------------------------------------------------------------------------------------------------ SE-AVELQDMSLLSIQQ---QEGV---QVVVQQPG----------------------PGL-------------------------LWLEEGPRQS------LQQCVAISIQQELYSPQEM EG-EEDLQAVSQLNIQQ---QSGL---HMVVQRGA----------------------SVLQPL-------VVVQQGV-------------GAQQN------IPTGVAISLQDGVYTFHDM IE-ENDAQGPSVAN-QH---DGVL---HAVMQRER----------------------CILEPL-------EVMTQSI-------------GIRNN------LEEVVAVGLPEGIYTVQEM ------------------------------------------------------------------------------------------------------------------------ TD-ETG-QEMSQLAVQP---AEGM---HIMEPQGE----------------------SGLQSL-------LGWQQYIN-----VQPELNEMPHQD------LSRCVELNIPEEIFSLEEM ETGEGGGTSIGEITLVQVQADLTV---IIHNVKL-----------------------QLNSVL-------KIDVRRTL--LQGVP-ITHTLPLPE------GVQVVKVGPNGELE-VERA ------------------------------------------------------------------------------------------------------------------------ PE------ERGRVAVPP---AEGM---HVVVQPAE----------------------GGFPAV-------LVLQQDLS-----------VLARPS------VRRCVAISLQEELFSLHEM PEEHERMVREGELPETIQGADVQM---TIGGTESRPVRLIAVDSNGIPVTDPTILQAAAEQAG-------IMFVSKDENDHENQISIDEAMQLRN---------------EENQQVPGYQ ADEHARMVTAGELPESVHGADVHM---QIPGAEAQQVRLIAVDSNGVPVTESAILQAAAEQAG-------IVFITKDDNGHDSQITIDQAMQLSM------RENPPMITATTAAVVLEQK ADEHARMVTAGELPESVHGADVHM---QIPGAEAQQVRLIAVDSNGVPVTESAILQAAAEQAG-------IVFITKDDNGHDSQITIDQAMQLSM------RENPPMITATTAAVVLEQK DNGQLSSMDQGVAQIAFSGAPVNMVGDNIVYQTTQ-------NTQYVPVSHNGTTQLAMTQSGGEPGTEVYTILQTVDGAETTTITTPTTMVVSSGGVHHLGDEQTHVIATTSGDHPSYA 361 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ELP----------------------------PQEDPSWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPGWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKNKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKNKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKNKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEDPNWQKDP-------DYQP---PAK-KTKKNKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEEPGWQKDP-------DYVP---PMK-KSKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQEEPGWQKDP-------DYVP---PMK-KSKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------QQEEPGWQKDP-------DYVP---PIK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------QQEEPGWQKDP-------DYVP---PIK-KTKKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQPP-------------------------PPQEDPNWAKDP-------EFQP---PAK-K-KKTKKSKLR----Y-TEE---------------------------GKDVDVSVYDFEE ELQ----------------------------PQDDPEWTKDP-------DYQPIT-AVR-KGKKGKKSRLR----Y-AEG---------------------------DRDMDVSVYDFEE ELQAAHEELQGTRVEEEEEDEEPAEVETSVPPQDDPEWTKDP-------DYQPIT-AVR-KGKKGKKSRLR----Y-AEG---------------------------DRDMDVSVYDFEE ELQAAHEELQGTRVEEEEEDEEPAEVETSVPPQDDPEWTKDP-------DYQPIT-AVR-KGKKGKKSRLR----Y-AEG---------------------------DRDMDVSVYDFEE ELQAA----------------------------EDPDWSKDP-------DYQPIT-TVR-KGKKGKKSRLR----Y-GEG---------------------------DRDMDVSVYDFEE ELQAAHEELQGTREEEEEEEEEPA--------EEDPDWSKDP-------DYQPIT-TVR-KGKKGKKSRLR----Y-GEG---------------------------DRDMDVSVYDFEE ELQAAHEEL-----------------------QEDPDWSKDP-------DYQPIT-TVR-KGKKGKKSRLR----Y-GEG---------------------------DRDMDVSVYDFEE ELQAAHEELQGTREEEEEEEEEAADVEPVVSQQEDPDWSKDP-------DYQPIT-TVR-KGKKGKKSRLR----Y-GEG---------------------------DRDMDVSVYDFEE ------------------------EVEATVPLEEDPEWSKDP-------DYQPIS-SLRNKGKKGKKSRLR----Y-GEG---------------------------NRDMDVSVYDFEE EMEADHDELLEVR----------AEVEATVPLEEDPEWSKDP-------DYQPIS-SLRNKGKKGKKSRLR----Y-GEG---------------------------NRDMDVSVYDFEE ELQAAQEDLQGQEGEEVEEDEEAAEIVTSV-PQDDPEWTKDP-------DYQPIT-AVR-KGKKGKKSRLR----Y-AEG---------------------------DRDMDVSVYDFEE EEG-----AETQPDEEEDEEEEPVQ-----PPNDDPNWAKDP-------DYQPPSGVVK-KIKKGKKSRLR----Y-AEG---------------------------DKDMDVSVYDFEE EEG-----AETQPDEEED-EEEPVQ-----PPNDDPNWAKDP-------DYQPPSGVVK-KIKKGKKSRLR----Y-AEG---------------------------DKDMDVSVYDFEE --------FSRSVRAHQHSAGAPMQ-----PPNNDPSWAKDP-------DYQPPSGVVK-KVKKGKKSRLR----Y-AEG---------------------------DKDMDVSVYDFEE ------------------------------VQNDDSAWSKDP-------DYQPPSAALK-KSKKGKKSRLR----Y-AEG---------------------------DKDMDVSVYDFEE --------QSTFGEERKEPPAALLH-----PQNDDASWAKDP-------DYQPPHGAFK-KPKKGKKSRLR----Y-GEG---------------------------DKDMDVSVYDFEE ELQ-----PQDDQPPHQEEEEEMAE-----PQNEDPAWSKDP-------DYTP---PVK-KVKKTKKSKLR----YNTEG---------------------------DKDMDVSVYDFEE ELQ-----PQDDQPPHQEEEEEMAE-----PQNEDPAWSKDP-------DYTP---PVK-KVKKTKKSKLR----YNTEG---------------------------DKDMDVSVYDFEE ELQ-----PQDDQPPHQEEEEEMAE-----PQNEDPAWSKDP-------DYTP---PVK-KVKKTKKSKLR----YNTEG---------------------------DKDMDVSVYDFEE EVMEINVVEESVEVSSEEDKLTVNS-----PLDENTELIK----------------LCEEREFTDQKEEIF----T-FEKLREGEK---------------------EEIILLPANSEIE EVMEINVVEESVEVSSEEDKLTVNS-----PLDENTELIKDKDKGIYGAEEGEVQQLCEEREFTDQKEEIF----T-FEKLREGEK---------------------EEIILLPANSEIE EVMEINVVEESVEISSEEDKLTVNP-----PLDENTESVKVE-------KNYEVPQLCEEREITDQKEGLF----T-FDKLREGEK---------------------EEIILLPANSEIE ------------------------------------------------------------------------------------------------------------------------ EVLQFHALEENVMVASEDSKLAVS-------LAETTGLIKLE-------EEQEKNQLLAER----TKEQLF----F-VETMSGDERS--------------------DEIVLTVSNSNVE EVMQINVLQEKVQAKDEENKS----------MDKSPGMLLIK---------KLVPKNLKNSVKIDRTKDLH----A-VEEILSCTA---------------------KDDISVSLNEPKE EVMHINCLKE-MQAFNEDEKS----------TRKTLDALRIE-----------RDRSIDVATDGDKGQPLL----V-AEEDRISPF-------------------------------CLA ------------------------------------------------------------------------------------------------------------------------ EMIENYIRDESADFFNED-KWIFDF-----PFDE--ELLKDQDKGIYG-AEWEAQELCEEREYTDPKEEIV----N-FETPRDGEK---------------------EEIILLLANSEIE PMG----------------------------SQDERSKEKDP-------DYQL---PVKKPVRKGRKNKLR----Y-KQE---------------------------AADADISVYDFEE ---------------------------------------------------------------------MR------------------------------------------------- ELVEIDVVEDSTDVSCEDRKLE---------------------------KQGMNQPLSEERELPDQREHLF----T-FEALGEGEE---------------------EEIILLPASSEME DQ----------------------------PPADPYDYQAEP-----------------EYHDSEKGVPLR----NYTSQDVVYEEAPENG----------------GIKQQENIYDYQD EK-----------------EVHQDT-----DGNDTEDESETK-----------------KPSVRKPRLKLR----VYSQKDGGVDEVATSFLDDGSLALTDEVETLEEKPNDESVYEFQ- EK-----------------EVHQDT-----DGNDTEDESETK-----------------KPSVRKPRLKLR----VYSQKDGGVDEVATSFLDDGSLALTDEVETLEEKPNDESVYEFQQ ELQ---------------------------PVSEDAAQQEEGALQMAAAEHEEVALIVQKPVKRKRGRPRKDEAAKMQTQIVIVREVVEG-----------------EDGQDPSVYDFYA 481 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKKGLG--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--DVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--DVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--DVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--DVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGMLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGMLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNIKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EQQ-------------------------EGLLS--EVNAEKVVGNMKPPKPTKIKKK--G--------V-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HKCHLCGRAFRTVTLLR EHE-------------------------DVHSS--EQDIDEVSGTAK----NQAKSK--G--------M-KRTFHCEICIFTSSRISSFNRHMKTHSDEKP--HMCHLCLKAFRTVTLLR EHE-------------------------DVHSS--EQDIDEVSGTAK----NQAKSK--G--------M-KRTFHCEICIFTSSRISSFNRHMKTHSDEKP--HMCHLCLKAFRTVTLLR EHE-------------------------DIPSS--EQDTDEVSGTAK----NQAKTK--D--------V-KQTFHCEICIFTSSKISCFNRHMKTHSDEKP--HMCHLCLKAFRTVTLLR -------------------------------------SCQDWYKSHL----KAYFIS--G--------V-NKTFHCDICKFTTSRQSSLNRHLKIHSDVKP--HVCHLCLKAFRSATLLR EQE-------------------------DQPTA--GQADAEKAKSTK----NQRKTK--G--------A-KGTFHCDVCMFTSSRMSSFNRHMKTHTSEKP--HLCHLCLKTFRTVTLLR QGE---------------------------QSV--VKKTDTLEAHTN----TQHRKK--G--------E-KVTIHCDLCAFTSLRMSSLNRHMKTHSDEKP--HLCHLCLKAFRTVTLLR EAA-------------------------KNLSS--RSKEDPVSFHNS----EKKDQS--N--------EGDVPQHCPFCTFTCFSIAGLRRHMKKHSEERP--HMCHLCLKAFRTVSLLR --------------------------------------------------------------------------HCRFCTYTSSSVTGLNRHMKRHSDKNP--HMCHLCLKVCRTVALLR EHE-------------------------DIHSP--PQDLDEVSQTAA----NQAETK--G--------T-KWTFHCEICKFTSSKMSSLTRHMKTHTAEKP--HMCHLCPKAFRTGTLLR QEE-------------------------GRLVSSQDVGVEKAIAP-KPPKPTRIKKK--G--------A-KKTFQCELCSYTCPRRSNLDRHMKSHTDERP--HCCHLCDRAFRTVTLLR --------------------------------------------------------------------VGGKTYQCYKCDYTCQRMAFLERHMKVHTDERP--FKCGTCEREFRTMQSLQ ERE-------------------------DVPAS--EQDLDEGSETAE----TQAEST--X--------X-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXX VPIQN-----------------------EPKIDNHYKKSQSNTQRTKYPGTIQVGAN--G--------EKRKVYQCSECAFYSHRHSNLIRHMKIHTDERP--YKCHLCARAFRTNTLLR ----------------------------DPP----TGGDTEQPSDVTMLDPTMFKKN--SKRATDKSRDRRKIYQCRECSFYSHRHSNLVRHMKIHTDERP--YKCHLCERSFRTNTLLR RQRGTMEEWRDRECEIILKDILQTLKDEDPP----TGGDTEQPSDVTMLDPTMFKKN--SKRATDKSRDRRKIYQCRECSFYSHRHSNLVRHMKIHTDERP--YKCHLCERSFRTNTLLR GED-------------------------DTAPV--AGGDEK----------SGIEVG--G-------AKKKTRYVVPKFDDGRLLDQVLNRAKKGGPGRRPKVHECHLCGRIFRTSTLLR 601 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooooo NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSATVGEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCP--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYCSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYCSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYSSVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVRWCRECIAVQ------------------------------------------------------- NHLNTHTGTRPHKCT--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVRWCRECIAVQ------------------------------------------------------- NHVNTHTGTRPYKCS--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHIRSHTGERPFHCCLCSYASKDTYKLKRHMRTHS---GEKPYECYVCHARFTQSGTMKIH NHVNTHTGTRPYKCS--DCDMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHIRSHTGERPFHCCLCSYASKDTYKLKRHMRTHS---GEKPYECYVCHARFTQSGTMKIH NHVNTHTGTRPYKCS--DCDMAFVTSGELVRHRRYKHTHEKPFKCTMCKYASVEASKLKRHIRSHTGERPFHCCLCNYASKDTYKLKRHMRTHS---GEKPYECYVCHARFTQSGTMKIH NHVNTHTGTKPYKCG--DCTMAFVTSGELVRHRRYKHTHEKPFQCTICKYASVEASKLKRHIRSHTGERPFRCRLCSYASRDTYKLKRHMRTHS---GEKPYECSVCQTKFTQRGTMKIH NHVNTHTGTRPYKCN--DCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS---GEKPYECHICHTRFTQSGTMKIH NHVNTHTGTRPYKCS--DCEMAFVTSGELARHRRYKHTLEKPFKCSVCKYSSVEASKLKRHIRSHTGERPYNCCLCSYASKDTYKLKRHMVTHS---GEKPYECYVCQARFTQSGTMKIH NHVNTHTGTKPHKCG--ECDMAFVTSGELSRHRRYKHTLEKPFKCTFCSYCSVEASKLKRHIRSHTGERPYHCTLCSYASRDTYKLKRHMVTHS---GEKPFECLICKARFTQAGTLKFH NHMNTHTGTKPYKCS--ECDMAFVTGGELSRHRRYKHTHEKPFKCTFCNYSSVEASKLKRHIRSHTGERPYNCTLCSYASRDTYKLKRHMLIHS---GEKPFECLICKARFTQAGTLKFH NHLNTHTGTRPYKCS--DCEMAFVTSGELGRHRRYKHTHEKRFKCSMCNYASVEASKLKRHIRSHTGERPFPCSFCNYASKDIFKLKRHMTSHS---GEKPYECSFCSARFSQSGTLKIH NHVNTHTGTKPHKCM--ECDMAFVTSGELVRHRRYRHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCGLCSYASRDTYKLKRHMRTHS---GEKPYECHVCHARFTQSGTMKMH NHINSHNGVKPHKCD--QCPMSFVTSGELMRHRRYKHTHEKPHKCTMCDYASVEISKLKRHMRSHTGERPFQCGMCSYASPDSYKLKRHMRTHT---GEKPYECSVCLATFTQSGSLKMH XXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXASKLKRHMRSHTGERPFHCCLCSYASKDTYKLKRHMRTHS---GEKPYECYICHARFTQSGTMKMH NHINTHLGVKPYKCPEANCEMAFVTSGELTRHRRYKHTHEKPFKCTLCEYASVEISKLRRHFRSHTGERPFSCDICGKAFADSFHLKRHKFSHT---GEKPYECPHCKARFTQHGSLKMH NHINTHTGVKPYKCTVDGCVMAFVTSGELTRHTRYIHTHEKPFRCTLCDYASVEISKLRRHFRSHTGERPYSCEECGKAFADSFHLKRHRMSHT---GEKPYECPECNQRFTQRGSVKMH NHINTHTGVKPYKCTVDGCVMAFVTSGELTRHTRYIHTHEKPFRCTLCDYASVEISKLRRHFRSHTGERPYSCEECGKAFADSFHLKRHRMSHT---GEKPYECPECNQRFTQRGSVKMH NHENTHSGTKPYKCE--LCPKAFGTSGELGRHMKYMHTHEKPHKCPLCDYLSVEASKIKRHMRSHTGEKPYKCTLCEYASTDNYKLKRHMRVHT---GERPFNCSQCDQSFSQKSSLKEH o 721 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------XXXXXXX-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMVMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMVMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMVMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQGERNGFCIRI------------TVDTIKN ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACR------------------------------ ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDTVFHERYALIQHQKSHKNEKRFKCDQ-------CEYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDTVFHERYALIQHQKSHKNEKRFKCDQ-------CEYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDTVFHERYALIQHQKSHKNEKRFKCDQ-------CEYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDTVFHERYALIQHQKSHKNEKRFKCDQ-------CEYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIEMGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIEMGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIEMGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIEMGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFLEKGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCEQ-------CDYCCRQ-ERHMVMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFLEKGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCEQ-------CDYCCRQ-ERHMVMHKR------------THTGEKP ILQKHTENVAKYHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKTHKNEKRFKCDQ-------CDYCCRQ-ERHMIMHKR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDLGGVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDLGGVHLRKQHSFIETGKKCRYCDAVFHERYALIQHQKSHKNEKRFKCDM-------CDYCCRQ-ERHMVMHRR------------THTGEKP ILQKHTENVAKFHCPH--CDTVIARKSDL-GVHLRKQHSYIEQGRKCRYCDAVFHERYALIQHQKSHKNEKRFKCDQ-------CDYACRQ-ERHMVMHKR------------THTGEKP --------LIKKYCPK-------------------------------------------------------------------------------------------------------- --------LIK-YCP--------------------------------------------------------------------------------------------------------- ILQKHSENVPKHQCPH--CSTVIARKSDL-RVHLRNLHSYKATEMKCRYCPAVFHERYALIQHQKTHRNEKRFKCDD-------CNYACKQ-ERHMTVHKR------------THTGEKP ILQKHSENVPKHQCPH--CSTVIARKSDL-RVHLRNLHSYKATEMKCRYCPAVFHERYALIQHQKTHRNEKRFKCDD-------CNYACKQ-ERHMTVHKR------------THTGEKP ILQKHSENVPKHQCPH--CATVIARKSDL-RVHLRNLHSYKAAEMKCRYCTDVFHERYALIQHQKTHRNEKRFKCDD-------CSYACKQ-ERHMRVHKR------------THTGEKP MLQKHTENAPKHQCPH--CGTMIARKSDL-RVHLKNLHSYKTTEIKCHYCSAAFHERYLLLQHQKTHRDEKRFKCGD-------CDYACKQ-ERHMIVHKR------------THTGEKP ILQKHGENVPKYQCPH--CATIIARKSDL-RVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNEKRFKCKH-------CSYACKQ-ERHMTAHIR------------THTGEKP ILQKHSENVPRYQCPH--CNAFIARKSDL-GVHLRNLHSYLAVAMKCSYCEAVFHERYALIQHKKTHRNEKRFKCDR-------CSYACKQ-ERHLIVHKR------------THTGEKP ILHKHETNVPKHQCPH--CQTSVARKGDL-SIHLRNLHSYIEVPLRCNYCDAAFHERYAFRQHKKTHRNEKRFKCDQ-------CNYACKQ-ERHMVIHKW------------THTGEKP KLHKHGTNVPKYQCPH--CNTAVARKGDL-RIHLQNLHSYIKVPLKCNFCEDAFHERHAFKQHKKTHINEKKFKCDQ-------CNYACKQ-GRHMVMHKR------------THTGEKP VLQKHSGNAPKHQCPH--CATLITRKSDL-RVHLRNLHSYSAAEMKCRYCTAAFHERYALIQHQKTHRDEKRFKCDV-------CSYACKQ-AQHMTIHKR------------IHTGEKP VLQKHTDNVPKYHCPH--CDAVIARKSDL-GVHLRKQHAVLERELRCRYCRAIFHERYALMQHQRTHRNEKRFKCDQ-------CEYACKQ-ERHMIMHKR------------VHTGEKP -MQRHLGTAPSYVCDI--CGTALTRKSDL-KSHVRKLHTGDKL-LTCKYCDSAFPDKYNLTKHLKTHQGEKRFRCED-------CNYCCTQ-ERHLINHKR------------CHTGEKP ILQKHSENVPKHQCPH--CATVIARKSDL-RVHLRNLHSYKATEMKCRYC-AVFHERYALIQHQKTHRNEKRFKCDD-------CSYACKQ----------------------------- VMQQHTKTAPKFECEREICHTMLGRKSDL-NVHLRKQHSYQEIPMQCRYCEEVFHDRWSLMQHQKTHRS-GRYRIDEDGNQIFDPDYDSEM-EDMEGGHGSGNLVYTEDGHVIGQDGSPN IMQQHTKTAPKFKCEI--CRTLLGRKSDL-NVHMRKQHAFQ------------------------------------------------------------------------------- IMQQHTKTAPKFKCEI--CRTLLGRKSDL-NVHMRKQHAFQ------------------------------------------------------------------------------- -EWKHVGNRPSHKCDH--CDTTFGRYADM-KTHVRKMHTAGE-PMICKICENAFTDRFTYMQHVRGHRGEKIYKCGE-------CGYSAPQ-KRHLVIHMR------------VHTGERP * 841 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCAGPD------------------GVEGENGGE--------T----KKSKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCSGPD------------------GVEGENGGE--------P----KKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PTFVPAAFVCSKCGKTFTRRNTMARHADNCTGPD------------------GVEGENGGE--------P----KKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCTGPD------------------GVEGENGGE--------P----KKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCTGLD------------------GIDGENGGE--------T----KKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCTGLD------------------GIDGENGGE--------T----KKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFV-AAFVCSKCGKTFTRRNTMARHADNCTGLD------------------GIDGENGGE--------T----KKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCSGLD------------------GGEGENGGE--------T----KKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCSGLD------------------GGEGENGGE--------T----KKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCSGLD------------------GGEGENGGE--------T----KKGKRGRKRKMRS FRVSVSSGAFDRQKQLLDMHFKRYHD-------PNFVPAAFVCSKCGKTFTRRNTMARHADNCTGLD------------------GIDGENGGE--------T----KKGKRGRKRKMRS ------------------------------------------------------------------------------------------------------------------------ YACSHCDKTF-RQKQLLDMHFKRYHD-------PSFVPAAFVCSKCGKTFTRRNTMSRHADSCTGPD------------------GTDGENGEE--------GEVIHKKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PSFVPAAFVCSKCGKTFTRRNTMSRHADSCTGPD------------------GTDGENGEE--------GEVIHKKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PSFVPAAFVCSKCGKTFTRRNTMSRHADNCTGPD------------------GTDGENGGE--------SEVVHKKGKRGRKRKMRS YACSHCDKTF-RQKQLLDMHFKRYHD-------PSFVPAAFVCSKCGKTFTRRNTMSRHADNCTGPD------------------GTDGENGGE--------SEVVHKKGKRGRKRKMRS YACSHCEKTF-RQKQLLDMHFKRYHD-------PTFVPATFVCTKCGKTFTRRNTMARHAENCTGPD------------------SVEGENGGE--------P----KKSKRGRKKKMRS FACSQCDKTF-RQKQLLDMHFKRYHD-------PSFIPTAFVCDKCSKTFTRRNTMLRHADNCTGDA------------------TLE-ENGTP--------PP---KKGRRGRKRKMQS FACSQCDKTF-RQKQLLDMHFKRYHD-------PSFIPTAFVCDKCSKTFTRRNTMLRHADNCTGDA------------------TLE-ENGTP--------PP---KKGRRGRKRKMQS FACSQCDKTF-RQKQLLDMHFKRYHD-------PSFIPTAFVCDKCSKTFTRRNTMLRHADNCTGDA------------------TLE-ENGTP--------PP---KKGRRGRKRKMQS FACSQCEKTF-RQKQLLDMHFKRYHD-------PTFVPTAFVCSKCSKTFTRRNTMLRHAENCMGDV------------------E-D-ENGTP--------TP---KKGRRGRKRKMQS FACSQCEKTF-RQKQLLDMHFKRYHD-------PTFVPTAFVCSKCSKTFTRRNTMLRHAENCMGDV------------------E-D-ENGTP--------TP---KKGRRGRKRKMQS FACSQCEKTF-RQKQLLDMHFKRYHD-------PNFVPTAFVCSKCSKTFTRRNTMLRHAENCMGDV------------------E-D-ENGTP--------TP---KKGRRGRKRKMQS FACSQCEKTF-RQKQLLDMHFKRYHD-------PNFVPTAFVCSKCSKTFTRRNTMLRHAENCMGDV------------------E-D-ENGTP--------TP---KKGRRGRKRKMQS FACSQCDKTF-RQKQLLDMHFKRYHD-------PNFVPTAFVCSKCNKTFTRRNTMLRHTENCSGEI------------------E-E-ENGTP--------AP---KKARRGRKRKMQT FACSQCDKTF-RQKQLLDMHFKRYHD-------PNFVPTAFVCSKCNKTFTRRNTMLRHTENCSGEI------------------E-E-ENGTP--------AP---KKARRGRKRKMQT FACEQCEKTF-RQKQLLDMHFKRYHD-------PTFVPTAFVCTKCSKTFTRRNTMLRHAEGCTGEA------------------SGD-ENGTP--------TP---KKGRRGRKRKMQA YACSQCEKTF-RQKQLLDMHFKRYHD-------PNFIPATFVCPKCNKTFTRRNTMARHAENCSGEV------------------E-DAENGAT--------IP---KKGRRGRKRKMRS YACSQCEKTF-RQKQLLDMHFKRYHD-------PNFIPATFVCPKCNKTFTRRNTMARHAENCSGEV------------------E-DAENGAT--------IP---KKGRRGRKRKMRS FGCSQCEKTF-RQKQLLDMHFKRYHD-------PNFVPTAFVCPKCSKTFTRRNTMARHAENCSGEV------------------D-DAENGAP--------TP---KKGRRGRKKKMRS YACSQCEKTF-RQKQLLDMHFKRYHD-------PNFIPTSFVCPKCSKTFTRRNTMARHAENCNGEI------------------D-DAENGTP--------TP---KRGRRGRKRKMRS YACSQCEKTF-RQKQLLDMHFKRYHD-------PNFIPTAFVCPKCSKTFTRRNTMVRHSENCNGEV------------------E-DAENGAP--------AP---KKGRRGRKRKMRS YACSQCEKTF-RQKQLLDMHFRRYHD-------PNFVPTSFVCTKCGKTFTRRNTMARHAENCTGMD------------------SADGENGTP--------P----KRGRGGRKRKMRS -----------KKKK--------------------------------------------------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------ FTCLSCNKCF-RQKQLLNVHFKKYHD-------KNFIPTVYECPKCGKGFSRWNNMRKHSEHCEAVK------------------GKSI-------------PS---AKGRKNKKKKQKD FTCLSCNKCF-RQKQLLNVHFKKYHD-------KNFIPTVYECPKCGKGFSRWNNMRKHSEHCEAVK------------------GKSI-------------PS---AKGRKNKKKKQKD FTCLSCNKCF-RQKQLLNVHFKKYHD-------KNFIPTVYECPKCGKGFSRWNNMRKHSELCEVIR------------------GKAV-------------QS---AKGRKTKKKKQKG FSCLHCNKRF-RQKRLLSVHFRKYHD-------ENFTPIVYECPKCGKAFSRLWILYERS-HFRYVE------------------WNSIFLCCRCARLFQCPSV---CNLRRTKRS---- FTCLSCNKCF-RQKQLLNAHFRKYHD-------ANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGE------------------AKSA-------------AS---GKGRRTRKRKQTI FTCVSCSKCF-RQKQLLTVHFRKHHD-------SNFKPTVYECPKCGKGYSRWNNMHKHAENCGLAR------------------AKVV-------------TR---HKGSKGKKKRWNS FVCVACSKCF-RQKQLLRVHFKKHHD-------SSFKPKVYECSKCSKEYSRWSNMHKHAEKCEDRR------------------AI---------------QP---SKGSKGKKKADKR FVCISCSKCF-RQKQLLTIHAKKYHD-------SSFQPKVFECPQCGKEYSRWNNMRKHAANCKGKS------------------VV---------------QP---SKGSKKRKKEEKR FTCLSCNKSF-RQKQLLKVHFKKYHD-------ETSVPPVHECPKCGKGFSRLNNMRKHSEHCEVVR------------------GKAV-------------PS---A-----KEKDQKG FECTLCDKTF-RQKQLLDFHFKRYHD-------PSFVPTTYECSKCHRNFTRRSTMMKHFDMCDGEL------------------ESGEQNGK---------AR---RGRRRGRKRKMQS FVCVQCDHTF-RQEQLLKQHIKVHHT-------PGYTPPRYACTNCDKSFTRKGNLR--------------------------------------------------------------- ------------------------------------------------------------------------------------------------------------------------ VIVQRVQHIDGQQGVPIEDHQQMQHDEHNMHAVEHQMDHSQEAPPIHQGHHRQAHAEAKSERFEQEQQHDPFAFDDDQNMGNGEYMHAPQMGQTMAQPVE-------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ YECEECHETF-KHKQTLINHQRSKHNLIQEADGTKKRKATDEITSPSKRITRRQRMQIQEEEETEEMVEPHTLTTADGNTIQVSMAQGGEGTVQLVQTSDGTMPVILTVGGDGQNVDEAL 961 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ KK-EDSSDS-ENA---E-------PDLDD--N------EDEEE--PAV-----EIEPEPEP--QPV-TPAPPPAKKRRGRPPGR-TNQPK------------QNQPTAIIQVEDQNTGAI KK-EDSSDSEENA---E-------PDLDD--N------EDEEE--TAV-----EIEAEPEV--EPV-APTPPPAKKRRGRPPGK-ANQPK------------QPQPAAIIQVEDQNTGAI KK-EDSSDSEENA---E-------PELDN--N------EEEEE--TAI-----EIEAEPEV--EPV-APVPPPAKKRRGRPPGK-SNQPK------------QTQPTTIIQVEDQNTDAI KK-ENSSDSEENA---E-------PELYDIEE------EDEEE--TAV-----EIEAEPEIEAEPV-APPPPPAKKRRGRPPGK-ANQPK------------QPQPTAIIQVEDESTGTI KK-EESSDSEENA---E-------PDLDD--N------EDEEE--TAV-----EIEAEPEV--QPV-TPAPPPAKKRRGRPPGK-SSQPK------------QTQPTAIIQVEDQNTGAI KK-EESSDSEENA---E-------PDLDD--N------EDEEE--TAV-----EIEAEPEV--QPV-TPAPPPAKKRRGRPPGK-ASQPK------------QTQPTAIIQVEDQNTGAI KK-EESSDS-ENA---E-------PDLDD--N------EDEEE--TAV-----EIEAEPEV--QPV-TPAPPPAKKRRGRPPGK-ASQPK------------QAQPTAIIQVEDQNTGAI KK-EDSSDSEENA---E-------PDLDD--N------EDEEE--TAV-----EIEAEPEV--SAE-APAPPPSKKRRGRPPGKAATQTK------------QSQPAAIIQVEDQNTGEI KK-EDSSDSEENA---E-------PDLDD--N------EDEEE--TAV-----EIEAEPEV--EPE-APAPPPSKKRRGRPPGKAATQTK------------QSQPAAIIQVEDQNTGEI KK-EDSSDSEENA---E-------PDLDD--N------EDEEE--TAV-----EIEAEPEV--EPE-APAPPPSKKRRGRPPGKAATQTK------------QSQPAAIIQVEDQNTGEI KK-EESSDSEENA---E-------PDLDD--N------EDEEE--TAV-----EIEAEPEV--QPV-TPAPPPAKKRRGRPPGK-ASQPK------------QTQPTAIIQVEDQNTGAI ------PVSWENA---E-------PNLDD--N------EDEEE--TAV-----EIEAEPEV--EQE-APAPPPSKKRRGRPPGKAAAQPK------------QSQPAAIIQVEDQNTGEI KK-EGSTDSEDNA---E-------PELDD--DDEDEDDDEEEE--TPV-----EIEADPEP-EEPV-SPIPPPAKKRRGRPPGK-ANQAK--------------QNAAVIQVEDHNTRAI KK-EGSTDSEDNA---E-------PELDD--DDEDEDDDEEEE--TPV-----EIEADPEP-EEPV-SPIPPPAKKRRGRPPGK-ANQAR--------------QNAAVIQVEDHNTRAI KK-EGSSDSDHNN---E-------PFFQD--N------AEPEQ--TPV-----EIEADPEP-EEPL-TPLPPPAKKRRGRPPGK-ANQAK--------------QNAAVIQVDDHSNRAI KK-EGSSDSEDNA---E-------PELED--DD-DEDEDDEDE--TPV-----EIEADPEP-EEPL-TPLPPPAKKRRGRPPGK-ANQAK--------------QNAAVIQVDDHSNRAI KR-DDSSGSDENA---E-------PELDD--I------DEEEE--EAVVINDEEMEGGPEA------LPAPPPAKKKRGRPPGK-SNQAK------------STQTAAIIQVEDQNAGTI RR-DDDDDDTVNI---E-------GELDE--------AEEEEDMLTEI-----EVEQAPSV--VPIPAPVEPPVKRKRGRPPKSKPDSK-------------RIIAAAIIRVEDETTGEV RR-DDDDDDT------E-------GELDE--------AEEEEDMLTEI-----EVEQAPSV--VPIPAPVEPPVKRKRGRPPKSKPDSK----------------PAAIIRVEDETTGEV RR-DDDDDDT------E-------GELDE--------AEEEEDMLTEI-----EVEQAPSV--VPIPAPVEPPVKRKRGRPPKSKPD------------------TAAIIRVEDETTGEV RK-DDDDDDDDDT---E-------PDQED--------MDDEDEMLSEI-----EVEQAPPV--VPIPAPVEPPVKRKRGRPPKNKPAGEF------------QDQPAAIIRVEDEVTGEV RK-DDDDDDDDDTVS-E-------PDQED--------MDDEDEMLSEI-----EVEQAPPV--VPIPAPVEPPVKRKRGRPPKNKPAVAKIVFFGG------FFPAAAIIRVEDEVTGEV RK-DDDDDDTGS----E-------PEPEE--------MDEEDEMLSEI-----EVEQAPPV--VPIPAPVEPPVKRKRGRPPKNKPA------------------TAAIIRVEDEATGEV RK-DDDDDDT------E-------PEPEE--------MDEEDEMLSEI-----EVEQAPPV--VPIPAPVEPPVKRKRGRPPKNKPA------------------TAAIIRVEDEATGEV RR-DDDDTGSNAK---E-------DELDE--------VEEEEE-LSEL-----EVEQDPPV--VPIPAPVEPPVKRKRGRPPKNKPNIPKSDLK--------LLTAAAIIRVEDEVTGEV RR-DDDDT--------E-------DELDE--------VEEEEE-LSEL-----EVEQDPPV--VPIPAPVEPPVKRKRGRPPKNKPNIPKSDLK--------LLTAAAIIRVEDEVTGEV RE-KKPDKVDSDT---E-------GELDE--------IEEEDDLLTEI-----EVEQAAPV--IPIPAPIEPPVKRKRGRPPKNKPEVCPCFSGIS------NLSVAAIIHVEDEVQ-EV RRDDDDDSDEDHA---EQDDDEEEGEGEE--ESSLLQEEEDP---ESM-----ELDQAPAA--IPVPAPDEPPVKRKRGRPPKNAPK-PPTPSKSVRVATKTTASAAAIIQVEDESTGAV RRDDDDDSDEDHA---EQDDDEEEGEGEE--ESSLLQEEEDP---ESM-----ELDQAPAA--IPVPAPDEPPVKRKRGRPPKNAPK-PPTPSKSVRVATKTTASAAAIIQVEDESTGAV RR-DEDDSDEDQL---E-PDDEDEAEEEE--EASLLLEEDEP---ESL-----ELDQAPAA--VPVPAPEEPPVKRKRGRPPKNAPK-VPAPSKPVRTPSK-TSSAAAVIQVEDESTGAV RR-DEEEDSEDHA---D--------------PDLLLQEEEEQ---DAM-----ELDQAPAT--VPVPAPEEPPVKRKRGRPPKNAPKPAPTPTKSPRVAAKAAATAAAIIQVEDESTGAV RR-DEEDSEDDNA---E--------FGEE--ETSLLQEEEEEEEPESM-----ELDQAPAA--IPVPAPDEPPVKRKRGRPPKNAPKPPPTPSRSARVAAKAAASAAALVQLEDESTGAV RK-DDDDDDDSDEHGEP--------------DLDDIDEEDEDDLLDEDQMG--LLDQAPPS--VPIPAPAEPPIKRKRGRPPKNAPKVSPTKSITK------TTTAAAIIQVEDESTGAI ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ PK-QDAKEEGRQT---------------RNFRSDKVVEQMPIEDTSIVNIEHHPNEIVPVVYGMAA-DV-EE------------------------------------------------ PK-QDAKEE--------------------------VVEQMPIEDTSIVNIEHHPNEIVPVVYGMAA-DV-EE------------------------------------------------ PK-QDVKEEGK-------------------------FEQMPIEDISNVNIERHTNEIVPVGYGIAT-DVAEE------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ LK-EATKGQKEAA---------------KGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEE------------------------------------------------ LK-QDVKQEGCSE-----------VSCGGLWESAGTVDLGSFQDVSVVNTECCASEIVPVEYGIET-STPRE------------------------------------------------ SS-HNRQREGSN------------------------------------------------------------------------------------------------------------ S----------------------------------------------------------------------------------------------------------------------- PE-QGAREEVLIG-----------FQTAQGLRNYKVIEEMPIEDISIVNIENATVEMVPVVYGTTS--DVQE------------------------------------------------ RK-HGSSSESDEMPTDE---------------------DEEEEELNEE-----SVEVADEE----VEEPEPPPMKRRRGRPPKAKPGRPA------KKVAGSDSVACGIIEIIPVTVGGP ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ QMMNGSLAAVQGHQDGEGQLMMAVPQGDGDNLHLEGQQASQQLQTSDD--------------------------IADDSQPPELQQEGQVQEVSAPRESSSITQEQAAALQQQMVSQGII 1081 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ENIIVEVKKEPD---------------AEPAEGEEEEAQPAAT--------------------------DAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AETV-GEEEEAQPAAV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPE---------------AETV-GATAGTQPAAA--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPE---------------AETV-GVAAGAQPEAV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AETVEGEEEEPQSAVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AEAVEGEEEEPPSAVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AEAAEGEEEEPQSAVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AETVE-EEEEAQPAVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AETVE-EEEEAQPAVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AETVE-EEEEAQPAVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AEAVEGEEEEPPSAVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------AETAE-EEEEAQPAVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVQVKKESD---------------LEAEVVVEAPVLTPAV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVQVKKESD---------------LEAEVVVEAPVLTPAV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVQVKKESD---------------LEAEGGVEAAVPTPAV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVQVKKESD---------------LEAEGGVEAAVPTPAV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- ENIIVEVKKEPD---------------TEEEEGEVEQAQPVVV--------------------------EAPNGDLTPE------------MILSMMDR--------------------- DDIIV--KKEVG------------ADQDDD---GNEAAQEVVV--------------------------APPNGDLTPE------------MILSMMDR--------------------- DDIIV--KKEVG------------ADQDDD---GNEAAQEVVV--------------------------APPNGDLTPE------------MILSMMDR--------------------- DDIIV--KKEVG------------ADQDDD---GNEAAQEVVVGEGKSTIQMEELSQGEGVAQAGQLSEAPPNGDLTPE------------MILSMMDR--------------------- DDIIV--KKEVG------------ADQDDQEICNEEAVEQVVV--------------------------APPNGDLTPE------------MILSMMDR--------------------- DDIIV--KKEVG------------ADQDDQEICNEEAVEQVM----------EELAQEEAAAQEVPLSEAPPNGDLTPE------------MILSMMDR--------------------- DDIIV--KKEVG------------ADQDDQEICSEEAVERCSC------------------------LRRRRNGDLTPE------------MILSMMDR--------------------- DDIIV--KKEVG------------ADQDDQEICSEEAVEQVVVGGGKSTIQMEELAQEEVAGQEVQLSEAPPKRRPNPRDDPQHDGPVMDASVKSVNTRLGFKKNLFLFFFFFFFFFSFS DDIIV--KKEVG------------VDRDDQEEATDGAVEE-----------------EAVAAPEV--SEAPPNGDLTPE------------MILSMMDR--------------------- DDIIV--KKEVG------------VDRDDQEEATDGAVEEVVVGEGKSTIQLEELPQEAVAAPEV--SEAPPNGDLTPE------------MILSMMDR--------------------- EELV---KKEVG---------------AEQVNCTDETTEQVITGGGKPGAQSEELSQADAAAQEVQLSAAPSNGDLTPE------------MILSMMDR--------------------- ENIIV--KKEEGDASAATPLDQGVALTVEGVGLD-EGVETVEL----------------PVNEET--AAASANGDLTPE------------MILSMMDR--------------------- ENIIV--KKEEGDASAATPLDQGVALTVEGVGLD-EGVETVEL----------------PVNEET--AAASANGDLTPE------------MILSMMDR--------------------- -DIIV--KKEEADGAAEAPLQGGVALAVEDAAMDAEGAETVEL----------------ADGEET---VAAANGDLTPE------------MILSMMDR--------------------- ENIIV--KKED-------PRAPGAGLAVEAVGLEAEEVEAVEV----------------QGTEDEAGAAAAANGDLTPE------------MILSMMDR--------------------- ENITV--KKEDSQAPEATPAEQGAAPA-------AEGAETVEL----------------PVNEDTASAAAAANGDLTPE------------MILSMMDR--------------------- ENIIV--KKEPE--------------------------GTDAVVAAQPIIEEVEAVEADVETVQLTVPEAAPNGDLTPE------------MILSMMDR--------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------PKTEVTCE------------MILNMMDK--------------------- -----------------------------------------------------------------------PKTEVTCE------------MILNMMDK--------------------- -----------------------------------------------------------------------QKTEVTCE------------MILNMMDK--------------------- ------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------VDEGVTCE------------MLLNTMDK--------------------- -----------------------------------------------------------------------QKTEMTCE------------MILNMMDK--------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------PQTEITFE------------MILNMIEK--------------------- DGPDDDEEEE--------------EEEEEAAEGEEGAVETAADEG--------------------------PKNDITPE------------MILSMMDQ--------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ SEGSVIAAMEEDEDGTGDGTIYLFVEEQ-------------------------------------------------------------------------------------------- 1201 .........+.........+......... ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- -------------------------KKKK ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- FGFRLTNACILKRNKHHCCNLRFHF---- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- ----------------------------- -----------------------------