1. =_numo_s_00000001_numo_e_gi|195338887|ref|XP_002036055.1| GM16366 [Drosophila se 2. =_numo_s_00000002_numo_e_gi|21711721|gb|AAM75051.1| RE02607p [Drosophila melanog 3. =_numo_s_00000003_numo_e_gi|194762235|ref|XP_001963260.1| wingless [Drosophila a 4. =_numo_s_00000004_numo_e_gi|195147122|ref|XP_002014529.1| GL18899 [Drosophila pe 5. =_numo_s_00000005_numo_e_gi|195117368|ref|XP_002003219.1| GI23655 [Drosophila mo 6. =_numo_s_00000006_numo_e_gi|195387788|ref|XP_002052574.1| wg [Drosophila virilis 7. =_numo_s_00000007_numo_e_gi|195052361|ref|XP_001993287.1| GH13724 [Drosophila gr 8. =_numo_s_00000008_numo_e_gi|60393086|gb|AAX19493.1| wingless [Lucilia sericata] 9. =_numo_s_00000010_numo_e_gi|253735641|dbj|BAH84842.1| wingless protein [Sarcopha 10. =_numo_s_00000011_numo_e_gi|170040118|ref|XP_001847858.1| wingless protein [Cule 11. =_numo_s_00000012_numo_e_gi|157127174|ref|XP_001661069.1| wingless [Aedes aegypt 12. =_numo_s_00000013_numo_e_gi|157013971|gb|EAL39184.3| AGAP009734-PA [Anopheles ga 13. =_numo_s_00000014_numo_e_ATTCE|ACEP_00006907-PA pep:known scaffold:Attacep1.0:sc 14. =_numo_s_00000015_numo_e_gi|21103973|gb|AAM33135.1| wingless [Pheidole morrisi] 15. =_numo_s_00000016_numo_e_gi|21103975|gb|AAM33136.1| wingless [Crematogaster line 16. =_numo_s_00000017_numo_e_gi|21103979|gb|AAM33137.1| wingless [Myrmica americana] 17. =_numo_s_00000018_numo_e_gi|340709126|ref|XP_003393164.1| PREDICTED: protein Wnt 18. =_numo_s_00000019_numo_e_gi|383864839|ref|XP_003707885.1| PREDICTED: protein Wnt 19. =_numo_s_00000020_numo_e_gi|380014047|ref|XP_003691055.1| PREDICTED: protein Wnt 20. =_numo_s_00000021_numo_e_gi|328792342|ref|XP_003251712.1| PREDICTED: protein Wnt 21. =_numo_s_00000023_numo_e_gi|345486197|ref|XP_001603388.2| PREDICTED: protein Wnt 22. =_numo_s_00000024_numo_e_gi|21103977|gb|AAM33138.1| wingless [Formica nitidivent 23. =_numo_s_00000025_numo_e_gi|307188089|gb|EFN72921.1| Protein Wnt-1 [Camponotus f 24. =_numo_s_00000030_numo_e_gi|242007977|ref|XP_002424791.1| protein wingless precu 25. =_numo_s_00000026_numo_e_gi|357615448|gb|EHJ69660.1| protein Wnt-1 precursor [Da 26. =_numo_s_00000027_numo_e_gi|389614525|dbj|BAM20310.1| wingless, partial [Papilio 27. =_numo_s_00000028_numo_e_gi|500860|dbj|BAA03211.1| Bm. Wnt-1 [Bombyx mori] 28. =_numo_s_00000029_numo_e_BOMMO|BGIBMGA006146-TA pep:known scaffold:Bmor1:nscaf28 29. =_numo_s_00000031_numo_e_gi|11907531|dbj|BAB19660.1| wingless protein [Gryllus b 30. =_numo_s_00000032_numo_e_gi|270008212|gb|EFA04660.1| wingless [Tribolium castane 31. =_numo_s_00000033_numo_e_gi|294610352|dbj|BAJ05334.1| wingless protein [Daphnia 32. =_numo_s_00000035_numo_e_gi|241620045|ref|XP_002407192.1| WNT-2 precursor, putat 33. =_numo_s_00000036_numo_e_gi|19171515|emb|CAC87040.1| wingless [Cupiennius salei] 34. =_numo_s_00000037_numo_e_gi|45544551|dbj|BAD12586.1| Wingless [Achaearanea tepid 35. =_numo_s_00000034_numo_e_gi|193712553|ref|XP_001945295.1| PREDICTED: protein Wnt 36. =_numo_s_00000040_numo_e_LATCH|ENSLACP00000021628 pep:novel scaffold:LatCha1:JH1 37. =_numo_s_00000041_numo_e_DANRE|ENSDARP00000110057 pep:known chromosome:Zv9:23:27 38. =_numo_s_00000042_numo_e_HOMSA|gi|4885655|ref|NP_005421.1| proto-oncogene Wnt-1 39. =_numo_s_00000043_numo_e_XENTR|ENSXETP00000021634 pep:known scaffold:JGI_4.2:GL1 40. =_numo_s_00000044_numo_e_gi|197320531|gb|ACH68427.1| wingless-type MMTV integrat 41. =_numo_s_00000046_numo_e_gi|184186101|ref|NP_001116972.1| protein Wnt-1 precurso 42. =_numo_s_00000047_numo_e_gi|87042260|gb|ABD16194.1| Wnt1 [Euprymna scolopes] 43. =_numo_s_00000048_numo_e_gi|3930521|gb|AAC80432.1| AmphiWnt1 [Branchiostoma flor 44. =_numo_s_00000049_numo_e_gi|17226368|gb|AAL37756.1|AF438206_1 signaling protein 1 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ --------------------------------------------------------------------------------MDISYI----FVICL-MALCSGGSSLSQVE-GKQKSGRGR --------------------------------------------------------------------------------MDISYI----FVICL-MALCSGGSSLSQVE-GKQKSGRGR --------------------------------------------------------------------------------MDISYI----FVICL-MALFSSDSSIVPVE-GKQKSGRGR --------------------------------------------------------------------------------MDISYI----FVISLMLALCS-----SQAE-SKQKSGRGR --------------------------------------------------------------------------------MDLSYI----FIVCL-LALYS-----ADAE-SKQKSGRGR --------------------------------------------------------------------------------MDLSYI----FIVCL-LALCS-----ADAE-SKQKSGRGR --------------------------------------------------------------------------------MDLSYM----FIVCL-LALCS-----ADAE-SKQKSGRGR --------------------------------------------------------------------------------MDLFTI----LRLLTVLLASL---ALTKAE-AKHKPGRGR --------------------------------------------------------------------------------MDLLRI----LRLLTILMISL---TFTKAE-AKHKPGRGR --------------------------------------------------------------------------------MELVTL----FLVCL-MAVSS---TSAEVE-SKSKPGRGR -------------------------------------------------------------------------------------------MIFLPLLFHR------------------- --------------------------------------------------------------------------------MNLVTV----FMVCL-MAISA----WAEVE-SKSKPGRGR -------------------------------------------------------------------------------MHTMCIL----TLVSR-IYDRD---YAPPER-STTYCWSNT ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------MVFHRSTKLDQNRDRIYAPRLHLIAKKNKKKMRLW----MIIGA-LAVAT---HASIAE-ITRNKNRGR ----------------------------------------------------------------------------------MRLW----VIIGA-LVVAI---HASIAE-ITRNKNRGR -------------------------------------------------------------------------MIAFDRQQKMRVW----VVICA-LVVAI---HASIAE-MPRNKNRGR --------------------------------------------------------------------MHTTPMIAFDRQQKMRLW----VIICA-LVVAI---HASIAE-MPRNKNRGR ----------------------------------------------------------------------------------MRLW----MMLGA-LAVAV---PTLPAE-VRTNKNRGR ------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------MRLW----MLLAV-LSVTA---YVSLAE-ITKNKNRGR ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------MC--------LRCE-AANKPRRGR --------------------------------------------------------------------------------MKCLWL----FVLTV-LC--------TRCE-AANKPRRGR --------------------------------------------------------------------------------MKCLWL----LVITV-LC--------LRCDTAGTKPRRGR ------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------MRAAAA----IPLLLLMALAG---LAARAA-TRAKMSRGR MAGTASERFVLRRVLALLLASEAELGGVHFHVSRTTRAPQCKAQCHKELCCGWSEQKLTPPKSDTGDIVYFLRSCVRVDTMKVTVI----FVMNL-FVLTA---L-GDVT-NARSKNRGK -----------------------------------------------------------------------------MSSMRTTVV----FVLVL-MMVLP---Y------LGTAKGRGR ------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------MIFCSVRAALL----FILVV-TLLIP---AQ-----AKPRHRGQR ------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------MKTTIVIKT-IVLMT-LVVDG---I-SRAY-AKHREGKYK ---------------------------------------------------------------------------LQGD-MKTVTLILG-LKTLWVLAFST----------LSNTLAVNN ---------------------------------------------------------------------------MWSDIMRVLALLLA-VKAACVLLVSS----------LTGTGAVNN --------------------------------------------------------------------------------MGLWALLPGWVSATLLLALAA----------LPAALAANS --------------------------------------------------------------------------------MRILTFLVG-LKTLWVLAFSS----------LSNTIAVNN --------------------------------------------------------------------------------MKFCYL----IIICL-YPTLSL---------GTGKAQGTT --------------------------------------------------------------------------------MKLEWF----VAFFF-IPTASL---------LAKKTTAAS --------------------------------------------------------------------------------MKSLYF----ILFCC-ICLYSCE--------KKVKKSRLR --------------------------------------------------------------------------------MKLVCTFWA-VVLLF-LAV------------VPVERVHAV -----------------------------------------------------------------------------MPAPKGAAF----VLIAA-LACAFV---------CEAQARKYK 121 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ oooooooooooooooooo ooooooooooooooooooooo oooooo GSMWWGIAKV---GEPNNITP---------I-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFSRG-KNLFGKIVDR-------------- GSMWWGIAKV---GEPNNITP---------I-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISKCQHQFRNRRWNCSTR--NFSRG-KNLFGKIVDR-------------- GSMWWGIAKV---GEPNNITP---------I-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTK--TISRG-KNLFGKIVDR-------------- GSMWWGIAKV---GEPNNMSP-----ITTGI-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKV---GEPNNISP-----ISTSI-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKV---GEPNNISP-----ISTGI-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANMAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKV---GEPNNISP-----ISTGI-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANMAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKV---GEPNNISP-----ISSGI-MYVD-PAIHTTLRRKQRHLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKV---GEPNNISP-----ISSGI-MYVD-PAIHTTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNNISP-----LANGM-IYMD-PAIHATLRRKQRRLARENPGVLAA-IAKGANMAINECQHQFRNRRWNCSTR--NFLRG-KNLFGKIVER-------------- -----GIAKA---GEPNNISP-----LANGM-IYMD-PAIHATLRRKQRRLARENPGVLAA-IAKGANMAINECQHQFRNRRWNCSTR--NFLRG-KNLFGKIVER-------------- GSMWWGIAKA---GEPNNISP-----LAPGM-AYLD-PAIHATLRRKQRRLARENPGVLAA-IAKGANLAINECQHQFRTRRWNCSTR--NFLRG-KNLFGKIVER-------------- AGSREGIAKA---GEPNNFLP-----MSAGS-IHME-P-VYATLRRKQRRLARENPGVLMS-VSRGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDR-------------- ---------A---GEPNNFLP-----MSAGS-IHME-P-VYATLRRKQRRLARENPGVLMA-VSRGANQAIAECQYQFRNRRWNCSTK--NFLKG-KNLFGKIVDR-------------- ---------A---GEPNNFLP-----MSASS-IHME-R-FYATLRRKQRRLAIENPGVLMA-VSRGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDR-------------- ---------A---GEPNNFLP-----MSAAS-IHME-P-IYTTLRRKQRKLARDNPGVLMA-VARGANQAITECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRRLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRKLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRRLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRRLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNNLLP-----MPATS-LHMD-PSVYATLRRKQRRLARENPGVLMA-VARGANQAISECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDR-------------- ---------A---DEPNNFLP-----VSPTS-L-MD-SSVYATLRRKQRRLVRENPGVLQA-VARGANQAVAECQHQFRNRRWNCSTK--NFLRG-KNLFGKIVDK-------------- GSMWWGIAKA---DEPNNFLP-----VSPTS-M-LD-SSVYGNLRRKQKKLIRDNPGVLQA-ISRGANQAVAECQYQFRNRRWNCSTK--NFLRG-KNLFGKIVDK-------------- --------------------------MSPGV-LSMD-PSVHQTLRRKQRRLARENPGVLVA-VAKGANQAILECQYQFRDRRWNCSTR--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNTLSP-----LSPGV-LYMD-PAVHATLRRKQRRLARENPGVLAA-VAKGASMAVAECQHQFKYRRWNCSTR--NFLRG-KNMFGKIVDR-------------- GSMWWGIAKA---GEPNNISP-----MSPGV-LYMD-AGVHSTLRRKQRRLAKENPGVLTA-VAKGANMAVAECQHQFKYRRWNCTTR--NFLRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNNLSP-----VSPGV-LFMD-PAVHATLRRKQRRLARENPGVLAA-VAK-AQYAFAECQHQFKYRRWNCSTR--NFLRG-KNLFGKIVDR-------------- -----GIAKA---GEPNNLSP-----VSPGV-LFMD-PAVHATLRRKQRRLARENPGVLAA-VAKGASMAVAECQHQFKYRRWNCSTR--NFLRG-KNLFGKIVDRENRSILIVEVQKSL GSKWWGIAKA---GEPNNLLP-----LAPGE-LYMD-PAVHATLRRKQRRLVRDHPGVLLA-VVKGANQAIGECQFQFRNRRWNCSTK--NFFRG-KNLFGKIVDR-------------- GSMWWGIAKA---GEPNNLSP-----ISPGG-VYMDLSSAHGTLRRKQRRLARENPGLLVA-LHKGANNAIHECQHQFRNQRWNCSTR--AFPRG-KNLFGKIVDK-------------- GSKWWGIARA---GEPNNLVSNSIKENSITN-SYLD-PDVHATLRRKQRRLVRDHPGVVVA-VAKGAKQAISECKHQFKNRRWNCPTK--DFHRG-RNLFGKIVDR-------------- ----------------------------------------SVPLRRKQRGLVRANPGSLQA-IGRGMRLAISECKHQFRDRRWNCPTP--EYMRG-KSLFGKIVHR-------------- GSRWWSLAFS---EEPTNLVVDFH--RGNSM-NDRG-PAPHLPLRKKQRRLVRDNPGAMQA-IGRGVKVAISECKYQFKKRRWNCPTA--DHARG-KNIFGKIVQR-------------- GSRWWNIAYS---EEISNFVVDFH--RTNTL-VGRG-FAPHTLLRKKQRRLVRENPGAMTA-IGRGVRLSISECKHQFKKRRWNCPTI--DYTRG-RNIFGKIVQK-------------- GTHWWGIAKA---GEPNNLAP-----MTPGL-MLMD-SSSLTLLRNKQRRLIREHPGVLQA-ISRGVNMALQECQHQFRNRRWNCSTK--NFLTG-KNLFGKIVDR-------------- SGRWWGLVNT---ASSTNLLT-----DSKNVQLVLD-PSLQ-LLSRKQRKLIRQNPGILHS-IASGLQSAIKECRWQFRNRRWNCPTT-----QS-PNVFGKIVNR-------------- SGRWWGIVNV---ASSGNLLT-----NSKNVQLVLD-PSLA-LLSRRQRKLIRQNPGILHA-IAAGLHTAIKECKWQFRNRRWNCPTT-----HS-PNVFGKIVNR-------------- SGRWWGIVNV---ASSTNLLT-----DSKSLQLVLE-PSLQ-LLSRKQRRLIRQNPGILHS-VSGGLQSAVRECKWQFRNRRWNCPTA-----PG-PHLFGKIVNR-------------- SGKWWGIVNV---ASAGNVLPGS---DAQPVPLVLD-PSLQ-LLSRRQKRLIRQNPGILQS-ITRGLHSAIRECKWQFRNRRWNCPTG-----TG-NQVFGKIINR-------------- TGKWWGVASS---QQKSNLVV-----NRAGVPVVVD----QTPLNKKQRKLIRLHPGSLSA-ITNSVGMSKTECKWQFKERRWNCPTN--KNDRGGRNLFGNILES-------------- STKWWSMVLS---PSMTNSVT-----DTQGIINIID-PKLK-ILNKRQRRLVSQNRGTLAA-INRAVKMAVSECRYQFKERRWNCPTF--NKDRGPESLFGKILNS-------------- AVRWWTLAHA---ESMNNMVV-----PQTQIQ-----NPTSLPLTRKQRNLVSKNPGSIRA-VYQGAKQAILECKYQFKNRRWNCPTY--ESGRG-VSVFGKILQK-------------- IGRWWGIASTVAVQEHANMVPGVA--RKPGSTIMLD-PKKH-PLNKKQRRLVRRNPGDAGEHRDRRPMLAIKECHHQFSKWRWNCPVN--TSDHV-NSVFGNILLR-------------- GPKWWNLGLS---VDPSNLMSNEILSNSLSD-HHLS-ESVQRMLRKKQRRLIRENDGVLVA-IAEGAKKAAKSCRYQFRSRRWDCSASRKKKIKR-RRLFGRIVSI-------------- * o*o * * o * ** **o*o o** *o 241 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ oooooooooooooooooooooooooooooooooooo ooooooooooooooooooooooooooooo o ------------------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETGFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRSP--------QANAQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETGFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRSP--------QANVQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRAP--------QAN-SMGAVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRT-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRAP--------QAS-TMGAVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRT-L ------------------------GCRETAFIYAITSAAVTHSVARACSEGSIESCTCDYSHHNREP--------QMN-NMGVVAGVGDWEWGGCSDNIGFGFKFSRDFVDTGERGRT-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRVS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSHAS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQLCSCDYTHQSRAS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFVYAIASAAVTHSIARACSEGSIQSCSCDYTHQSRAS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------SGTRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGTIQSCSCDYTHQSRPP-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------SATRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------STTRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYSHQSRGP-----------------SGVRDWEWGGCSDNIGYGFRFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRTS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRTS-----------------SAVRDWEWGGCSDNIGYGFTFSRDFVDTGERGRN-L ------------------------GCRETAFIYAITSAAVTHAVARACSEGAIKSCTCDYSHQGRGPLPTRIAHHQARGPTNTLPGVRDWEWGGCSDNIGFGFKFSRAFVDTGEKGRN-L ------------------------GCRETAFLYAITSAGVTHAVSRACAEGAIESCTCDYSHVDRAP--------HRS-RAATAANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKT-L ------------------------GCRETAFIYAITSAGVTHAVSRACAEGSIESCTCDYSHLERTP--------HRT-RAAAAANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKT-L ------------------------GCRETAFIYAITSAGVTHSLARACREASIESCTCDYSHRPRAA---------QN-PVGGRANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKT-L NRYLEEVDAPAVPIVMIELIISRVGCRETAFIYAITSAGVTHSVARACAEGSIESCTCDYSHIDRVP--------HRT-RSAAAANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKT-L ------------------------GCRETAFIYAITSAGVTHAIARACAEGSIQSCTCDYRHAGRVA--------GGRGGGGGGGKKPDWEWGGCSDNIEYGFKFSRDFVDTGERGRT-L ------------------------GCRETAFIYAITSAAVTHAIARACSEGSIDTCNCETHYKGRPH-------VSGNGGGAAVAGVRDFEWGGCSDNIGFGFTVSREFVDAGERGKT-I ------------------------ACRETAFIYALMSAAVTHSVSRACSEGAIESCTCDYSQRGPSG--------------------ADWEWGGCSDNIQFGVKFSREFVDAGEKGRD-I ------------------------GCRETAFVYAITSAGVAHAVSRACSEGAIDTCTCDYRQRGPSG--------------------LDWEWGGCSDNVHFGYKFARAFVDAAERGRD-L ------------------------GCRETAFLYAITSAGVTHSLSRACREGLVSTCNCDYRRRGPSG--------------------LHWEWGGCSDNIDFGAKFSRQFVDASERGKD-L ------------------------GCRETAFLYAITSAGVTHAMARACREGLVTSCSCDYKRRGPSG--------------------LDWEWGGCSDNIEFGSKFTKQFVGAAERGKD-L ------------------------GFRETAFIYAITSAGVTHAVSRACAEGVIETCTCDTTHQRRGP-----------YIQNSVPGVKDWEWGGCSDNIDFGYKFSRMFVDTGERGRS-L ------------------------GCRETAFIFAITSAGVTHSVTRSCSEGSIESCTCDYRRRGPGG--------------------PDWHWGGCSDNIDFGRVFGREFVDSSERGRD-L ------------------------GCRETAFVFAITSAGVTHAVARSCSEGAIESCTCDYRRRGPGG--------------------PDWHWGGCSDNVEFGRMFGREFVDSSERGRD-L ------------------------GCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGG--------------------PDWHWGGCSDNIDFGRLFGREFVDSGEKGRD-L ------------------------GCRETAFVFAITSAGVTHSVARSCSEGSIESCSCDYRRRGPGG--------------------PDWHWGGCSDNIEFGRFIGREFVDSSERGRD-L ------------------------GCRETAFIYAITASAVAHSVARSCSEGSIETCNCDYEKRGKGG--------------------KGWEWGGCSDNADFGSNFSRKFVDAGEKGRD-L ------------------------GCRETSFIYSITSAAVTHSVARSCSEGTIESCTCDYKFRGDSG--------------------NDWEWGGCSDNADFGHRFGKKFVDSGEKGRD-L ------------------------GCRETAFIYAITSAAISHAVARACATGTIYTCTCDYSAKPPGH-------------ETVTPDSSNWKWGGCSDNAKFGHKFGRRFVDVVEKGQD-I ------------------------GCTQTAFIYAVMSAAVAHEVGRNCAEGTIETCSCDYRSKGPAG--------------------EDWEWGGCSDNVEFGKQFAKQFVDAGEKTKDSV ------------------------PCRETAFVYALLSAAVLHSVTRACTEGAVHSCSCHYTAKG-----------------------DDWEWGGCSENIDFGYRFSRHFVDAGEKTHE-I o o*o*oooo oooo * oo* * o o * * o *****o* o* oo ** *oo o 361 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooo REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNSLRATNALAPV----SPNAA-GSNS-------VSSNGLII REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNSLRATNALAPV----SPNAA-GSNS-------VGSNGLII REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVVGDNLKARFDGATRVQVNNHRSQNS--IPV---ISPNAV-GSNT-------AGPNAL-M REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSANAVAV---VSPNAAMGSNS------NGGSNGL-L REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVPV---VNPNAA-GPNSVVVAGVGVGGNG--L REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVAV---VSPNAA-GSNS-VVGGVSGGGNG--L REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVAV---ISPNAA-GSNG-VVGGVSNGGNG--L REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKDRFDGASRVMMSNSLRPSGSANAVGTANSPNAV------------GSSSSVIS REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKDRFDGASRVMMSNSLRPSGSANAA-NAGSPNAV------------G-PTNGVL REKMNLHNNEAGR------S--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDLLKDRFDGASRVMVSNSLRTT-VNEAT----LSNRA-NPNGLKS-PNQVGSS---- REKMNLHNNEAGR------A--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDLLKDRFDGASRVMVSNSLRTS-VNEAT----LSNRA-NPNGLKA-QNQLGGSSPGG REKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTMKTCWMRLNSFRTIGDILKDRFDGASRVMVSNSLRSTSVNENT----LTNRA-GSANLKTNANSVGGSA--S REKMNLHNNEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRARVTNNAI----TSNSA-------------------- REKMNLHNNEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRARVNNNAI----TSNSA-------------------- REKMNLHNNEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRLVGDNLKDRFDGASRVMVSNSDRVRVSNNAI----TSNSA-------------------- REKMNLHNNEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRVNNNAI----MSNSA-------------------- REKMNLHNNEAGR------A--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA-------------------- REKMNLHNNEAGR------A--------HVSSGMRQDCKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA-------------------- REKMNLHNNEAGR------A--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA-------------------- REKMNLHNNEAGRAVSFFFA--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA-------------------- REKMNLHNNEAGR------T--------HVSAEMRQECKCHGMSGSCTVKTCWMRLPSFRQVGDNLKDRFDGASRVMVSNSDRARGVSNAI----TSNSA-------------------- REKMNLHNNEAGR------T--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNSDRVRSNV-------HVNSA-------------------- REKMNLHNNEAGR------TGVVSVLLQHVSSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNSDRVRSNANL------------------------------ REKMNLHNNEAGR------V--------HVSMGMRQECKCHGMSGSCTVKTCWMRLPTFREIGDSLKDRFDGASRVMLSNAGSMRSLN-------------------------------- REKMNLHNNEAGR------M--------HVQTEMRQECKCHGMSGSCTVKTCWMRLPSFRSVGDALKDRFDGASRVMMPNTEVEAPVQ-------------------------------- REKMNLHNNEAGR------A--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRSVGDALKDRFDGASRVLMSNSDVETPVL-------------------------------- REKMNLHNNEAGR------R--------HVQTEMKQECKCHGMSGSCTVKTCWMRLPSFRSVGDSLKDRFDGASRVMLSKADVETPAQ-------------------------------- REKMNLHNNEAGR------A--------HVQTEMKQECKCHGMSGSCTVKTCWMRLPSFRSVGDSLKDRFDGASRVMLSKAELETPAQ-------------------------------- REKMNLHNNEAGR------L--------HVREEMRKECKCHGMSGSCTVKTCWMRLPHFRVVGDNLKDRFDGASRVLVGNAGSPRGPG-------------------------------- REKMNLHNNEAGR------W--------HVKDQMRQECKCHGMSGSCTIKTCWMRLPPFRVIGDLLKDRFDGASHVAASGHHRNNNNA-------------------------------- RYMMNLHNNEAGR------V--------HVSTEMRQECKCHGMSGSCTVRTCWMRLPFFRVVGDNLKDRFDGASRVLISNTGRTPGNG-------------------------------- RFVINLHNNEAGR------L--------QVTTETRRECKCHGMSGSCTVKTCWMRLPSFRDVGNQLKERFDGASKVLVSNQGNFRGFR-------------------------------- RYIMNLHNNEAGR------A--------HVIGGMRRQCKCHGMSGSCTVQTCWMQLSPFRTIGDGLKDRFDGASRVLVTNRGNVR----------------------------------- RFTMNLHNNEAGR------T--------HVAAGMRRQCKCHGMSGSCTVQTCWMQLPPFRAVGDGLKDRFDGASRVLVTNRGNVR----------------------------------- REKMNLHNNEAGR------M--------HVQSEMKQECKCHGMSGSCTVKTCWMRLPIFRSIGDNLKDRFDGASRVMVGNAGGLRRMRSDDNTPNSHYEQ-------------------- RYLMNLHNNEAGR------V--------TVFSEMRQECKCHGMSGSCTVKTCWMRLPTFRSIGDFLKDRFDGASRVIYGNKGSNRAS--------------------------------- RYLTNLHNNEAGR------M--------TVASEMQQECKCHGMSGSCTVRTCWMRLPSFRLVGDYLKDRFDGASRVVYANKGSNRAS--------------------------------- RFLMNLHNNEAGR------T--------TVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRAS--------------------------------- KYLVNLHNNQAGR------L--------TVLTEMRQECKCHGMSGSCSLRTCWMRLPPFRSVGDALKDRFDGASKVTYSNNGSNRWG--------------------------------- RYYMNKHNNAAGR------R--------IVTDNMRRECKCHGMSGSCQVKTCWMRLPTFREVGDILKERFDGASQIAQTNNGHNRGTR-------------------------------- RHAMNLHNNEAGR------K--------TVSSEMRRECKCHGMSGSCTIETCWMRLPTFRTVGELIKERFDGASRVTMRNDGSPS----------------------------------- RYMMNLHNNAAGR------V--------HVTSQMTQACKCHGMSGSCQIKTCWMKLPTFRRVGDLLKDRFDGASRVLPGNAGSDRRRRRKF----------------------------- RYLVNMHNNEAGR------V--------AVAENLRRECKCHGMSGSCTLKTCWMRLPNFRDVGDSLKEKFDGASKVAFPDIGNNRGSR-------------------------------- RAAMNLHNNEAGR------Q--------HVRAAMRSECKCHGMSGSCTVKTCWSRLPHFKQIGDRLKEKFDGASRVMSRHTAHMQRRSNSR----------------------------- o * *** *** * ********** o *** * o o*o oo o****o o 481 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ oooooooooooooooo PQSGLVYGEEEERMLNDHMPD-ILLENSHPISKIHHPNMPSPNSLPQ-AGQRGGR---NGR--RQGRK-----------------------------HNRYHFQLNPHNPEHKPPGSKDL PQSGLVYGEEEERMLNDHMPD-ILLENSHPISKIHHPNMPSPNSLPQ-AGQRGGR---NGR--RQGRK-----------------------------HNRYHFQLNPHNPEHKPPGSKDL PQS-VVYGEEEERMLNDHMPDSLLLENSHPS---------KSNSLPQ-AGQ-PNR---NGH--RRGRK-----------------------------HNRYSFQLNPHNPEHKPPGSKDL QSA-VSVYEEEERMLNDHMPD-LLLDNTHLSSKIHHPNMPSPNSLPM-AGA-RSR---NGR--RQGRK-----------------------------HNRYHFQLNPHNPEHKPPGSKDI PPS-VSGYDDEERMLNDHMPE-LLLDNSHPNSKQHHPNMPSPNSLPV-AGA-RSRG--HGR-GRLGRK-----------------------------HNRYHFQLNPHNPEHKPPGPKDI PAS-VSGYDDEERMLNDHMPE-LLLDNSHPNGKQHHPNMPSPNSLPV-AGA-RARG--HGR-GRQGRK-----------------------------HNRYHFQLNPHNPEHKPPGPKDI PPS-VNGYDDEERMLNDHIPE-LLLDNNHPNSKQHHPNMPSPNSLPV-AGA-RSRG--HGR-GRQGRK-----------------------------HNRYHFQLNPHNPEHKPPGPKDI PNAASPNAYDEDRMLNDE------------HVVKHHPNMPSPNSLPTSSNA-VSRNSVRGR-QRQGKK-----------------------------NNRYSFQLKPHNPDHKPPGTKDI PNVASSNGYEDDRMLNDE------------HVLKHHPNMPSPNSLPN-PNS-ASRNSVRGR-QRQGKK-----------------------------NNRYSFQLKPHNPDHKPPGTKDI PNS-------------------------------------------------VSSNSIHAR-SHQQKK-----------------------------INRYNFQLKPHNPDHKPPGMKDL PNS-------------------------------------------------VSSNSIHAR-SHQQKKINRSF-----GDFQRWTKFLSKIFEFPSSINRYNFQLKPHNPDHKPPGTKDL PNS-------------------------------------------------VLSNSIHAR-GHQQKRASERSLISLKTIHQYLTCFVSPLFFLC--SRRYNFQLKPYNPEHKPPGSKDL ------------------------------------------------------SNSVHQH-RDGLGR-----------------------------RQRYNFQLKPYNPEHKPPGQKDL ------------------------------------------------------SNSVHQH-REGLGR-----------------------------RQRYNFQLKPYNPEHKPPGQKDL ------------------------------------------------------SNSVHQH-RDGLGR-----------------------------RHRYNFQLKPYNPEHKPPGQKDL ------------------------------------------------------SNSVHQH-REGLGR-----------------------------RHRYNFQLKPYNPEHKPPGQKDL ------------------------------------------------------SNSVHGH-REGLGR-----------------------------RHRYNFQLKPYNPEHKPPGPKDL ------------------------------------------------------SNSVHGH-RDGLGR-----------------------------RHRYNFQLKPYNPEHKPPGPKDL ------------------------------------------------------SNSVHGH-REGLGR-----------------------------RHRYNFQLKPYNPEHKPPGPKDL ------------------------------------------------------SNSVHGH-REGLGR-----------------------------RHRYNFQLKPYNPEHKPPGPKDL ------------------------------------------------------SNSVHAH-REGLSR-----------------------------RHRYNFQLKPYNPEHKPPGVKDL ------------------------------------------------------SNSVHQH-RDGLAR-----------------------------RQRYNFQLKPYNPEHKPPGPKDL ------------------------------------------------------ANSVHQH-RDGLSR-----------------------------RQRYNLQLKPYNPEHKPPGPKDL ---------------------------------------------------------------SGRKK-----------------------------RNKYNLQLKPYDPDHKPPGTKDL ------------------------------------------------------RNDAAPH-R--VPR-----------------------------RDRYRFQLRPHNPDHKTPGVKDL ------------------------------------------------------RNDPGAH-R--VPR-----------------------------RDRYRFQLRPYNPDHKAPGAKDL ------------------------------------------------------RNEAAPH-R--VPR-----------------------------KDRYRFQLRPHNPDHKSPGVKDL ------------------------------------------------------RNEAAPH-R--VPR-----------------------------KDRYRFQLRPHNPDHKSPGVKDL ---------------------------------------------------------------AGKGK-----------------------------GNRYNFQLQPYDAQHKPPGRKDL -----------------------------------HQNRPPKNPKLNA----ISSNSIHSK-RE-NRR-----------------------------KHKYGFQLKPFNPEHKPPGTKDL -------------------------------------------------------------------------------------------------RKKYNYQLKPYNPEHKAPSKKDL ---------------------------------------------------------------SRRRK-----------------------------GHARSFQLKPLYPDHKPPTRKDL ----------------------------------------------------------------------------------------------------RRALLKPYHPEHKPPSKKDL ----------------------------------------------------------------------------------------------------RRALFKPYHPEHKPPSKKDL ---------------------------------EQQQEQPQDQLTQQQPQQNGGGGGVRGRGRRRGGG-----------------------------RNRYNFQLKPYDPDLKAPGTKDL --------------------------------------------------------------------------------------------------RADILHLEPENPAHKPPLPRDL -------------------------------------------------------------------------------------------------HRADPRHLEPENPAHKLPSSRDL --------------------------------------------------------------------------------------------------RAELLRLEPEDPAHKPPSPHDL -------------------------------------------------------------------------------------------------SRSDPPHLEPENPTHALPSSQDL -------------------------------------------------------------------------------------------------RKKRIKHFESADPQHKHPTASDL -------------------------------------------------------------------------------------------------DRETESSFVPYNPSHKQPASRDL -------------------------------------------------------------------------------------------------TFTPKFTFTPFDPNHKAPSKKDL ---------------------------------------------------------------------------------------------------AKVTGLVPKNSRHKFPTDNDL --------------------------------------------------------------RRSIKR-----------------------------KRRKNLDLQPYNPDHKSPSAMDL o o * *o 601 .........+.........+.........+.........+.........+.........+.........+.........+..... ooooooooooooooooooooooooooooooooooooooooooooooo VYLEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL---- VYLEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL---- VYLEPSPSFCEKNLRHGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL---- VYLEPSPSFCEKNLRHGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVIVVERCACTFHWCCEVKCKLCRTKKVIYTCL---- VYLESSPSFCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL---- VYLEPSPSFCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL---- VYLEPSPSFCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL---- VYLEPSPSFCEKNLRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKTIHTCL---- VYLEPSPPFCEKNLRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKTIHTCL---- VYLEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVIVVERCACTFHWCCEVKCKLCRTKKIIHTCL---- VYLEPSPGFCDRNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVIVVERCACTFHWCCEVKCKLCRTKKIIHTCL---- VYLEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVTVVERCSCTFHWCCEVKCKLCRAKKIIHTCL---- VYVEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCTFHWCCEVKCQLCRTKKTVHTCL---- VYVEPSPPFCEKNPKLGILGTYGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCT-------------------------- VYVEPSPPFCEKNPKLGILGTQGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCT-------------------------- VYVEQSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEVTV--------------------------------- VYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCRIKKTIHTCL---- VYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCRIKKTIHTCL---- VYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCKIKKTIHTCL---- VYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCKIKKTIHTCL---- VYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEIIVVERCNCTFHWCCEVKCQLCRTKKTIHTCL---- VYLEQSPAFCEKNPALGILGTHGRQCNDTSLGVDGCDLMCCGRGYKTQEVVVIERCNCI-------------------------- VYLEQSPAFCEKNPKLGILGTHGRQCNETSLGVDGCDLMCCGRGYKTQEMVVIERCACIFHWCCEVKCQKCRTTKTVHTCL---- VYLDPSPDFCERNPKLGIQGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEMMVTERCRCTFHWCCEVKCDYCRTKKTVHTCL---- VYLESSPGFCEKNPRLGIPGTHGRTCNDTSIGVDGCDLMCCGRGYRTETMFVVERCNCTFHWCCDVKCKLCRTEKVVHTCL---- VYLESSPGFCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTETKFVVERCN---------------------------- VYLESSPGFCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTNTMFVVERCNCTFHWCCEVKCKLCRTEKVVHTCL---- VYLESSPGFCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTNTMFVVERCNCTFHWCCEVKCKLCRTEKVVHTCL---- VYLDQSPNFCERNPRQGIQGTHGRECNETSLGLDGCDLMCCGRGHRSQEVMLVERCHCTFHWCCEVKCKTCHVRKTIHTCQ---- VYYEMSPGFCEKNPKLGIQGTHGRLCNDTSMGVDGCDIMCCGRGYRTQEVVVFERCNCTFHWCCEVKCDVCRTKRTIHTCVKKKK VYYENSPNFCEKNLKLGIAGTQGRVCNETSIGVDGCDLMCCGRGYKTEVKEVVERCACTFHWCCEVKCKVCRTKKTIHTCL---- VYFENSPDFCVPNSRLGVQGTRGRHCNESSPGVDGCESMCCGRGHRTEVREDLERCACTFHWCCQVKCKVCKIRRTVHTCL---- VYFENSPDFCYADPSLGHSATLGRTCNVSSLGVDGCDLMCCGRGYKSENREEVSRCNCTFHWCCQVECKTCKTKRLVHECL---- VYFENSPDFCFPDSNLGHRGTLGRICNASSIGVDGCDLMCCGRGHKAEHREETSRCNCTFHWCCQVECRTCKTRRLVHSCL---- VYLETSPGFCDPNPRLGVLGTHGRQCNETSLGLDGCDLMCCGRGHKTHQALVSERCNCTFLWCCEVKCSVCQYRKTVNTCQ---- VYFEKSPNFCTYNGKTGTLGTAGRYCNSSSPALDGCELLCCGRGYRTRTEKVTERCNCTFHWCCHVSCLNCTNTQVLHECL---- VYFEKSPNFCSYNGKTGTHGTSGRTCNSSSPALDGCELLCCGRGYKTRMEQVTERCHCTFHWCCHVSCLNCTSTQTVHQCL---- VYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL---- VYFEKSPNFCSASEKNGTPGTTGRICNSTSLGLDGCELLCCGRGYRSRAEKVTERCHCTFHWCCHVTCLNCTSSQIVHECL---- VYFEESPDFCELNKKVGSLGTRGRQCNNTSIGIDGCDLLCCERGYRSEIEQVTERCSCTFHWCCQVKCETCVTQRTVHTCL---- VYFENSPDFCERNDKFGTPGTRGRECNATSLGVDGCDLMCCSRGSTTTEIKVKERCSCTFHWCCKVKCEECTSFRTVHRCL---- VYFEKSPEFCNQNNNIGFKGTVGRECNDTSLGLEGCDLMCCGRGHKTQTYMVVERCNCTFRWCCEVMCEACRITKMKHTCL---- VYHERSPNFCRNNPRLGFEGTRGRECNVTSRGLDGCDLLCCGRGYATRQEVTKERCNCTFQWCCQVKCEECVRTKTIHTCL---- VYLQESPNFCVRNRTLGIPGTSERECNGTSIGVEGCNLMCCGRGYSSRVVEVVERCSC----------------------I---- ** o ** ** * o* * ** o* ooo** o** **