1. =_numo_s_00000001_numo_e_gi|195338887|ref|XP_002036055.1| GM16366 [Drosophila se 2. =_numo_s_00000002_numo_e_gi|21711721|gb|AAM75051.1| RE02607p [Drosophila melanog 3. =_numo_s_00000003_numo_e_gi|194762235|ref|XP_001963260.1| wingless [Drosophila a 4. =_numo_s_00000004_numo_e_gi|195147122|ref|XP_002014529.1| GL18899 [Drosophila pe 5. =_numo_s_00000005_numo_e_gi|195117368|ref|XP_002003219.1| GI23655 [Drosophila mo 6. =_numo_s_00000006_numo_e_gi|195387788|ref|XP_002052574.1| wg [Drosophila virilis 7. =_numo_s_00000007_numo_e_gi|195052361|ref|XP_001993287.1| GH13724 [Drosophila gr 8. =_numo_s_00000008_numo_e_gi|60393086|gb|AAX19493.1| wingless [Lucilia sericata] 9. =_numo_s_00000009_numo_e_gi|74054133|gb|AAZ95456.1| wingless-like protein, parti 10. =_numo_s_00000010_numo_e_gi|253735641|dbj|BAH84842.1| wingless protein [Sarcopha 11. =_numo_s_00000011_numo_e_gi|170040118|ref|XP_001847858.1| wingless protein [Cule 12. =_numo_s_00000012_numo_e_gi|157127174|ref|XP_001661069.1| wingless [Aedes aegypt 13. =_numo_s_00000013_numo_e_gi|157013971|gb|EAL39184.3| AGAP009734-PA [Anopheles ga 14. =_numo_s_00000014_numo_e_ATTCE|ACEP_00006907-PA pep:known scaffold:Attacep1.0:sc 15. =_numo_s_00000015_numo_e_gi|21103973|gb|AAM33135.1| wingless [Pheidole morrisi] 16. =_numo_s_00000016_numo_e_gi|21103975|gb|AAM33136.1| wingless [Crematogaster line 17. =_numo_s_00000017_numo_e_gi|21103979|gb|AAM33137.1| wingless [Myrmica americana] 18. =_numo_s_00000018_numo_e_gi|340709126|ref|XP_003393164.1| PREDICTED: protein Wnt 19. =_numo_s_00000019_numo_e_gi|383864839|ref|XP_003707885.1| PREDICTED: protein Wnt 20. =_numo_s_00000020_numo_e_gi|380014047|ref|XP_003691055.1| PREDICTED: protein Wnt 21. =_numo_s_00000021_numo_e_gi|328792342|ref|XP_003251712.1| PREDICTED: protein Wnt 22. =_numo_s_00000022_numo_e_gi|350419248|ref|XP_003492119.1| PREDICTED: protein win 23. =_numo_s_00000023_numo_e_gi|345486197|ref|XP_001603388.2| PREDICTED: protein Wnt 24. =_numo_s_00000024_numo_e_gi|21103977|gb|AAM33138.1| wingless [Formica nitidivent 25. =_numo_s_00000025_numo_e_gi|307188089|gb|EFN72921.1| Protein Wnt-1 [Camponotus f 26. =_numo_s_00000030_numo_e_gi|242007977|ref|XP_002424791.1| protein wingless precu 27. =_numo_s_00000026_numo_e_gi|357615448|gb|EHJ69660.1| protein Wnt-1 precursor [Da 28. =_numo_s_00000027_numo_e_gi|389614525|dbj|BAM20310.1| wingless, partial [Papilio 29. =_numo_s_00000028_numo_e_gi|500860|dbj|BAA03211.1| Bm. Wnt-1 [Bombyx mori] 30. =_numo_s_00000029_numo_e_BOMMO|BGIBMGA006146-TA pep:known scaffold:Bmor1:nscaf28 31. =_numo_s_00000031_numo_e_gi|11907531|dbj|BAB19660.1| wingless protein [Gryllus b 32. =_numo_s_00000032_numo_e_gi|270008212|gb|EFA04660.1| wingless [Tribolium castane 33. =_numo_s_00000033_numo_e_gi|294610352|dbj|BAJ05334.1| wingless protein [Daphnia 34. =_numo_s_00000035_numo_e_gi|241620045|ref|XP_002407192.1| WNT-2 precursor, putat 35. =_numo_s_00000036_numo_e_gi|19171515|emb|CAC87040.1| wingless [Cupiennius salei] 36. =_numo_s_00000037_numo_e_gi|45544551|dbj|BAD12586.1| Wingless [Achaearanea tepid 37. =_numo_s_00000034_numo_e_gi|193712553|ref|XP_001945295.1| PREDICTED: protein Wnt 38. =_numo_s_00000038_numo_e_gi|290753130|dbj|BAI79510.1| wingless [Ephoron eophilum 39. =_numo_s_00000045_numo_e_gi|164521693|gb|ABY60732.1| wingless [Euperipatoides ka 40. =_numo_s_00000040_numo_e_LATCH|ENSLACP00000021628 pep:novel scaffold:LatCha1:JH1 41. =_numo_s_00000041_numo_e_DANRE|ENSDARP00000110057 pep:known chromosome:Zv9:23:27 42. =_numo_s_00000042_numo_e_HOMSA|gi|4885655|ref|NP_005421.1| proto-oncogene Wnt-1 43. =_numo_s_00000043_numo_e_XENTR|ENSXETP00000021634 pep:known scaffold:JGI_4.2:GL1 44. =_numo_s_00000044_numo_e_gi|197320531|gb|ACH68427.1| wingless-type MMTV integrat 45. =_numo_s_00000046_numo_e_gi|184186101|ref|NP_001116972.1| protein Wnt-1 precurso 46. =_numo_s_00000047_numo_e_gi|87042260|gb|ABD16194.1| Wnt1 [Euprymna scolopes] 47. =_numo_s_00000039_numo_e_gi|312376154|gb|EFR23329.1| hypothetical protein AND_13 48. =_numo_s_00000048_numo_e_gi|3930521|gb|AAC80432.1| AmphiWnt1 [Branchiostoma flor 49. =_numo_s_00000049_numo_e_gi|17226368|gb|AAL37756.1|AF438206_1 signaling protein 1 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ -------------------------------------------------------------------------------------------------MDISYI----FVICL-MALCSGG -------------------------------------------------------------------------------------------------MDISYI----FVICL-MALCSGG -------------------------------------------------------------------------------------------------MDISYI----FVICL-MALFSSD -------------------------------------------------------------------------------------------------MDISYI----FVISLMLALCS-- -------------------------------------------------------------------------------------------------MDLSYI----FIVCL-LALYS-- -------------------------------------------------------------------------------------------------MDLSYI----FIVCL-LALCS-- -------------------------------------------------------------------------------------------------MDLSYM----FIVCL-LALCS-- -------------------------------------------------------------------------------------------------MDLFTI----LRLLTVLLASL-- ------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------MDLLRI----LRLLTILMISL-- -------------------------------------------------------------------------------------------------MELVTL----FLVCL-MAVSS-- ------------------------------------------------------------------------------------------------------------MIFLPLLFHR-- -------------------------------------------------------------------------------------------------MNLVTV----FMVCL-MAISA-- ------------------------------------------------------------------------------------------------MHTMCIL----TLVSR-IYDRD-- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------MVFHRSTKLDQNRDRIYAPRLHLIAKKNKKKMRLW----MIIGA-LAVAT-- ---------------------------------------------------------------------------------------------------MRLW----VIIGA-LVVAI-- ------------------------------------------------------------------------------------------MIAFDRQQKMRVW----VVICA-LVVAI-- -------------------------------------------------------------------------------------MHTTPMIAFDRQQKMRLW----VIICA-LVVAI-- ------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------------------------------MRLW----MMLGA-LAVAV-- ------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------------------------------MRLW----MLLAV-LSVTA-- ------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------------------------MC----- -------------------------------------------------------------------------------------------------MKCLWL----FVLTV-LC----- -------------------------------------------------------------------------------------------------MKCLWL----LVITV-LC----- ------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------MRAAAA----IPLLLLMALAG-- MAGTASERFVLRRVLALLLASEAELGGVHFHVSRT-----------------TRAPQCKAQCHKELCCGWSEQKLTPPKSDTGDIVYFLRSCVRVDTMKVTVI----FVMNL-FVLTA-- ----------------------------------------------------------------------------------------------MSSMRTTVV----FVLVL-MMVLP-- ------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------------------MIFCSVRAALL----FILVV-TLLIP-- ------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------MKTTIVIKT-IVLMT-LVVDG-- ------------------------------------------------------------------------------------------------------------------------ ITTRIDLSLDVFMYYHLCYTLNVSCARSYHEGAKEGADIFTKQLKLSNERFGEYSSHNRSHPGSNRPESGHNPESLAAATDISSCRVFYLSEMGMSSAKMKHF----LLLAL-LLLCPQ- --------------------------------------------------------------------------------------------LQGD-MKTVTLILG-LKTLWVLAFST-- --------------------------------------------------------------------------------------------MWSDIMRVLALLLA-VKAACVLLVSS-- -------------------------------------------------------------------------------------------------MGLWALLPGWVSATLLLALAA-- -------------------------------------------------------------------------------------------------MRILTFLVG-LKTLWVLAFSS-- -------------------------------------------------------------------------------------------------MKFCYL----IIICL-YPTLSL- -------------------------------------------------------------------------------------------------MKLEWF----VAFFF-IPTASL- -------------------------------------------------------------------------------------------------MKSLYF----ILFCC-ICLYSCE ------------------------------------------------------------------------------------------------------------------------ -------------------------------------------------------------------------------------------------MKLVCTFWA-VVLLF-LAV---- ----------------------------------------------------------------------------------------------MPAPKGAAF----VLIAA-LACAFV- 121 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ SSLSQVE-GKQKSGRGRGSMWWGIAKV---GEPNNITP---------I-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFSRG-KNLFGKI SSLSQVE-GKQKSGRGRGSMWWGIAKV---GEPNNITP---------I-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISKCQHQFRNRRWNCSTR--NFSRG-KNLFGKI SSIVPVE-GKQKSGRGRGSMWWGIAKV---GEPNNITP---------I-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTK--TISRG-KNLFGKI ---SQAE-SKQKSGRGRGSMWWGIAKV---GEPNNMSP-----ITTGI-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKI ---ADAE-SKQKSGRGRGSMWWGIAKV---GEPNNISP-----ISTSI-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKI ---ADAE-SKQKSGRGRGSMWWGIAKV---GEPNNISP-----ISTGI-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANMAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKI ---ADAE-SKQKSGRGRGSMWWGIAKV---GEPNNISP-----ISTGI-MYMD-PAIHSTLRRKQRRLVRDNPGVLGA-LVKGANMAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKI -ALTKAE-AKHKPGRGRGSMWWGIAKV---GEPNNISP-----ISSGI-MYVD-PAIHTTLRRKQRHLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKI -------------------------------------------------------------------------------LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKI -TFTKAE-AKHKPGRGRGSMWWGIAKV---GEPNNISP-----ISSGI-MYVD-PAIHTTLRRKQRRLVRDNPGVLGA-LVKGANLAISECQHQFRNRRWNCSTR--NFLRG-KNLFGKI -TSAEVE-SKSKPGRGRGSMWWGIAKA---GEPNNISP-----LANGM-IYMD-PAIHATLRRKQRRLARENPGVLAA-IAKGANMAINECQHQFRNRRWNCSTR--NFLRG-KNLFGKI ----------------------GIAKA---GEPNNISP-----LANGM-IYMD-PAIHATLRRKQRRLARENPGVLAA-IAKGANMAINECQHQFRNRRWNCSTR--NFLRG-KNLFGKI --WAEVE-SKSKPGRGRGSMWWGIAKA---GEPNNISP-----LAPGM-AYLD-PAIHATLRRKQRRLARENPGVLAA-IAKGANLAINECQHQFRTRRWNCSTR--NFLRG-KNLFGKI -YAPPER-STTYCWSNTAGSREGIAKA---GEPNNFLP-----MSAGS-IHME-P-VYATLRRKQRRLARENPGVLMS-VSRGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKI --------------------------A---GEPNNFLP-----MSAGS-IHME-P-VYATLRRKQRRLARENPGVLMA-VSRGANQAIAECQYQFRNRRWNCSTK--NFLKG-KNLFGKI --------------------------A---GEPNNFLP-----MSASS-IHME-R-FYATLRRKQRRLAIENPGVLMA-VSRGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKI --------------------------A---GEPNNFLP-----MSAAS-IHME-P-IYTTLRRKQRKLARDNPGVLMA-VARGANQAITECQHQFRNRRWNCSTK--NFLRG-KNLFGKI -HASIAE-ITRNKNRGRGSMWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRRLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKI -HASIAE-ITRNKNRGRGSMWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRKLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKI -HASIAE-MPRNKNRGRGSMWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRRLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKI -HASIAE-MPRNKNRGRGSMWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRRLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKI -------------------MWWGIAKA---GEPNNFLP-----MSPAS-LHMD-PTVYATLRRKQRRLARENPGVLMA-VARGANQAIAECQHQFRNRRWNCSTK--NFLRG-KNLFGKI -PTLPAE-VRTNKNRGRGSMWWGIAKA---GEPNNLLP-----MPATS-LHMD-PSVYATLRRKQRRLARENPGVLMA-VARGANQAISECQHQFRNRRWNCSTK--NFLRG-KNLFGKI --------------------------A---DEPNNFLP-----VSPTS-L-MD-SSVYATLRRKQRRLVRENPGVLQA-VARGANQAVAECQHQFRNRRWNCSTK--NFLRG-KNLFGKI -YVSLAE-ITKNKNRGRGSMWWGIAKA---DEPNNFLP-----VSPTS-M-LD-SSVYGNLRRKQKKLIRDNPGVLQA-ISRGANQAVAECQYQFRNRRWNCSTK--NFLRG-KNLFGKI -------------------------------------------MSPGV-LSMD-PSVHQTLRRKQRRLARENPGVLVA-VAKGANQAILECQYQFRDRRWNCSTR--NFLRG-KNLFGKI ---LRCE-AANKPRRGRGSMWWGIAKA---GEPNTLSP-----LSPGV-LYMD-PAVHATLRRKQRRLARENPGVLAA-VAKGASMAVAECQHQFKYRRWNCSTR--NFLRG-KNMFGKI ---TRCE-AANKPRRGRGSMWWGIAKA---GEPNNISP-----MSPGV-LYMD-AGVHSTLRRKQRRLAKENPGVLTA-VAKGANMAVAECQHQFKYRRWNCTTR--NFLRG-KNLFGKI ---LRCDTAGTKPRRGRGSMWWGIAKA---GEPNNLSP-----VSPGV-LFMD-PAVHATLRRKQRRLARENPGVLAA-VAK-AQYAFAECQHQFKYRRWNCSTR--NFLRG-KNLFGKI ----------------------GIAKA---GEPNNLSP-----VSPGV-LFMD-PAVHATLRRKQRRLARENPGVLAA-VAKGASMAVAECQHQFKYRRWNCSTR--NFLRG-KNLFGKI -LAARAA-TRAKMSRGRGSKWWGIAKA---GEPNNLLP-----LAPGE-LYMD-PAVHATLRRKQRRLVRDHPGVLLA-VVKGANQAIGECQFQFRNRRWNCSTK--NFFRG-KNLFGKI -L-GDVT-NARSKNRGKGSMWWGIAKA---GEPNNLSP-----ISPGG-VYMDLSSAHGTLRRKQRRLARENPGLLVA-LHKGANNAIHECQHQFRNQRWNCSTR--AFPRG-KNLFGKI -Y------LGTAKGRGRGSKWWGIARA---GEPNNLVSNSIKENSITN-SYLD-PDVHATLRRKQRRLVRDHPGVVVA-VAKGAKQAISECKHQFKNRRWNCPTK--DFHRG-RNLFGKI ---------------------------------------------------------SVPLRRKQRGLVRANPGSLQA-IGRGMRLAISECKHQFRDRRWNCPTP--EYMRG-KSLFGKI -AQ-----AKPRHRGQRGSRWWSLAFS---EEPTNLVVDFH--RGNSM-NDRG-PAPHLPLRKKQRRLVRDNPGAMQA-IGRGVKVAISECKYQFKKRRWNCPTA--DHARG-KNIFGKI -----------------GSRWWNIAYS---EEISNFVVDFH--RTNTL-VGRG-FAPHTLLRKKQRRLVRENPGAMTA-IGRGVRLSISECKHQFKKRRWNCPTI--DYTRG-RNIFGKI -I-SRAY-AKHREGKYKGTHWWGIAKA---GEPNNLAP-----MTPGL-MLMD-SSSLTLLRNKQRRLIREHPGVLQA-ISRGVNMALQECQHQFRNRRWNCSTK--NFLTG-KNLFGKI -------------------------------------------------------------------------------------------------RRWNCSTK--NFLRG-KNLFGKI --------AALPAKKNRGSRWWGLAHL---GHSNNLIL-----NSRGNPVYAD-QSLQ-PLNRKQRRLVRENPGTLGS-VTKGAHMAIAECKYQFRNRRWNCPTT--DY----------- --------LSNTLAVNNSGRWWGLVNT---ASSTNLLT-----DSKNVQLVLD-PSLQ-LLSRKQRKLIRQNPGILHS-IASGLQSAIKECRWQFRNRRWNCPTT-----QS-PNVFGKI --------LTGTGAVNNSGRWWGIVNV---ASSGNLLT-----NSKNVQLVLD-PSLA-LLSRRQRKLIRQNPGILHA-IAAGLHTAIKECKWQFRNRRWNCPTT-----HS-PNVFGKI --------LPAALAANSSGRWWGIVNV---ASSTNLLT-----DSKSLQLVLE-PSLQ-LLSRKQRRLIRQNPGILHS-VSGGLQSAVRECKWQFRNRRWNCPTA-----PG-PHLFGKI --------LSNTIAVNNSGKWWGIVNV---ASAGNVLPGS---DAQPVPLVLD-PSLQ-LLSRRQKRLIRQNPGILQS-ITRGLHSAIRECKWQFRNRRWNCPTG-----TG-NQVFGKI --------GTGKAQGTTTGKWWGVASS---QQKSNLVV-----NRAGVPVVVD----QTPLNKKQRKLIRLHPGSLSA-ITNSVGMSKTECKWQFKERRWNCPTN--KNDRGGRNLFGNI --------LAKKTTAASSTKWWSMVLS---PSMTNSVT-----DTQGIINIID-PKLK-ILNKRQRRLVSQNRGTLAA-INRAVKMAVSECRYQFKERRWNCPTF--NKDRGPESLFGKI --------KKVKKSRLRAVRWWTLAHA---ESMNNMVV-----PQTQIQ-----NPTSLPLTRKQRNLVSKNPGSIRA-VYQGAKQAILECKYQFKNRRWNCPTY--ESGRG-VSVFGKI ------------------------------------------------------------------------------------------------------------------------ --------VPVERVHAVIGRWWGIASTVAVQEHANMVPGVA--RKPGSTIMLD-PKKH-PLNKKQRRLVRRNPGDAGEHRDRRPMLAIKECHHQFSKWRWNCPVN--TSDHV-NSVFGNI --------CEAQARKYKGPKWWNLGLS---VDPSNLMSNEILSNSLSD-HHLS-ESVQRMLRKKQRRLIRENDGVLVA-IAEGAKKAAKSCRYQFRSRRWDCSASRKKKIKR-RRLFGRI 241 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ oooooooooo VDR--------------------------------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETGFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRSP--------QANAQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETGFIYSITSAAVTHSIARACSEGSIESCTCDYSHQSRSP--------QANAQAGSVAGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETGFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRSP--------QANVQAGSVAGVRDWEWGGCSDNIGFGF VER--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRAP--------QAN-SMGAVAGVRDWEWGGCSDNIGFGF VER--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRAP--------QAS-TMGAVAGVRDWEWGGCSDNIGFGF VER--------------------------------------GCRETAFIYAITSAAVTHSVARACSEGSIESCTCDYSHHNREP--------QMN-NMGVVAGVGDWEWGGCSDNIGFGF VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRVS-----------------SAVRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSHAS-----------------SAVRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQLCSCDYTHQSRAS-----------------SAVRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFVYAIASAAVTHSIARACSEGSIQSCSCDYTHQSRAS-----------------SAVRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------SGTRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGTIQSCSCDYTHQSRPP-----------------SAVRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------SATRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------STTRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------SGTRDWEWGGCSDNI---- VDR--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYSHQSRGP-----------------SGVRDWEWGGCSDNIGYGF VDK--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRTS-----------------SAVRDWEWGGCSDNIGYGF VDK--------------------------------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRTS-----------------SAVRDWEWGGCSDNIGYGF VDR--------------------------------------GCRETAFIYAITSAAVTHAVARACSEGAIKSCTCDYSHQGRGPLPTRIAHHQARGPTNTLPGVRDWEWGGCSDNIGFGF VDR--------------------------------------GCRETAFLYAITSAGVTHAVSRACAEGAIESCTCDYSHVDRAP--------HRS-RAATAANVRVWKWGGCSDNIGFGF VDR--------------------------------------GCRETAFIYAITSAGVTHAVSRACAEGSIESCTCDYSHLERTP--------HRT-RAAAAANVRVWKWGGCSDNIGFGF VDR--------------------------------------GCRETAFIYAITSAGVTHSLARACREASIESCTCDYSHRPRAA---------QN-PVGGRANVRVWKWGGCSDNIGFGF VDRENRSILIVEVQKSLNRYLEEVDAPAVPIVMIELIISRVGCRETAFIYAITSAGVTHSVARACAEGSIESCTCDYSHIDRVP--------HRT-RSAAAANVRVWKWGGCSDNIGFGF VDR--------------------------------------GCRETAFIYAITSAGVTHAIARACAEGSIQSCTCDYRHAGRVA--------GGRGGGGGGGKKPDWEWGGCSDNIEYGF VDK--------------------------------------GCRETAFIYAITSAAVTHAIARACSEGSIDTCNCETHYKGRPH-------VSGNGGGAAVAGVRDFEWGGCSDNIGFGF VDR--------------------------------------ACRETAFIYALMSAAVTHSVSRACSEGAIESCTCDYSQRGPSG--------------------ADWEWGGCSDNIQFGV VHR--------------------------------------GCRETAFVYAITSAGVAHAVSRACSEGAIDTCTCDYRQRGPSG--------------------LDWEWGGCSDNVHFGY VQR--------------------------------------GCRETAFLYAITSAGVTHSLSRACREGLVSTCNCDYRRRGPSG--------------------LHWEWGGCSDNIDFGA VQK--------------------------------------GCRETAFLYAITSAGVTHAMARACREGLVTSCSCDYKRRGPSG--------------------LDWEWGGCSDNIEFGS VDR--------------------------------------GFRETAFIYAITSAGVTHAVSRACAEGVIETCTCDTTHQRRGP-----------YIQNSVPGVKDWEWGGCSDNIDFGY VDR--------------------------------------GCRETAFIYAITSAAVTHAVSRACSEGSIESCTCDYSQRGPAAALGSIAT-NGASNGVVGPGQRDWEWGGCSDNLAFGY -SH--------------------------------------GCRETSFIYAITSAAVTHQIARSCSEGTIESCTCDYRKRGPSG--------------------RDWEWGGCSDNIEFGY VNR--------------------------------------GCRETAFIFAITSAGVTHSVTRSCSEGSIESCTCDYRRRGPGG--------------------PDWHWGGCSDNIDFGR VNR--------------------------------------GCRETAFVFAITSAGVTHAVARSCSEGAIESCTCDYRRRGPGG--------------------PDWHWGGCSDNVEFGR VNR--------------------------------------GCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGG--------------------PDWHWGGCSDNIDFGR INR--------------------------------------GCRETAFVFAITSAGVTHSVARSCSEGSIESCSCDYRRRGPGG--------------------PDWHWGGCSDNIEFGR LES--------------------------------------GCRETAFIYAITASAVAHSVARSCSEGSIETCNCDYEKRGKGG--------------------KGWEWGGCSDNADFGS LNS--------------------------------------GCRETSFIYSITSAAVTHSVARSCSEGTIESCTCDYKFRGDSG--------------------NDWEWGGCSDNADFGH LQK--------------------------------------GCRETAFIYAITSAAISHAVARACATGTIYTCTCDYSAKPPGH-------------ETVTPDSSNWKWGGCSDNAKFGH ---------------------------------------------------------------------------------------------MNSMGAVAAGVGDWEWGGCSDNIGFGF LLR--------------------------------------GCTQTAFIYAVMSAAVAHEVGRNCAEGTIETCSCDYRSKGPAG--------------------EDWEWGGCSDNVEFGK VSI--------------------------------------PCRETAFVYALLSAAVLHSVTRACTEGAVHSCSCHYTAKG-----------------------DDWEWGGCSENIDFGY o *****o* 361 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ oooooo oooooooooooooo ooooooooooooooooooooooooooooooooooooooooooooooo KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNSLRATNALAPV----SPNAA-GS KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNSLRATNALAPV----SPNAA-GS KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVVGDNLKARFDGATRVQVNNHRSQNS--IPV---ISPNAV-GS KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSANAVAV---VSPNAAMGS KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVPV---VNPNAA-GP KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVAV---VSPNAA-GS KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVAV---ISPNAA-GS KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKDRFDGASRVMMSNSLRPSGSANAVGTANSPNAV--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKDRFDGASRVTMSNSLRPSGSANAVPAANSPNAV--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKDRFDGASRVMMSNSLRPSGSANAA-NAGSPNAV--- KFSREFVDTGERGRT-LREKMNLHNNEAGR------S--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDLLKDRFDGASRVMVSNSLRTT-VNEAT----LSNRA-NP KFSREFVDTGERGRT-LREKMNLHNNEAGR------A--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDLLKDRFDGASRVMVSNSLRTS-VNEAT----LSNRA-NP KFSRDFVDTGERGRT-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTMKTCWMRLNSFRTIGDILKDRFDGASRVMVSNSLRSTSVNENT----LTNRA-GS KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRARVTNNAI----TSNSA--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRARVNNNAI----TSNSA--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRLVGDNLKDRFDGASRVMVSNSDRVRVSNNAI----TSNSA--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRVNNNAI----MSNSA--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVSSGMRQDCKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------A--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA--- KFSREFVDTGERGRN-LREKMNLHNNEAGRAVSFFFA--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA--- ---------GERGRN-LREKMNLHNNEAGR------A--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDR-------------------- RFSREFVDTGERGRN-LREKMNLHNNEAGR------T--------HVSAEMRQECKCHGMSGSCTVKTCWMRLPSFRQVGDNLKDRFDGASRVMVSNSDRARGVSNAI----TSNSA--- KFSREFVDTGERGRN-LREKMNLHNNEAGR------T--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNSDRVRSNV-------HVNSA--- TFSRDFVDTGERGRN-LREKMNLHNNEAGR------TGVVSVLLQHVSSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNSDRVRSNANL------------- KFSRAFVDTGEKGRN-LREKMNLHNNEAGR------V--------HVSMGMRQECKCHGMSGSCTVKTCWMRLPTFREIGDSLKDRFDGASRVMLSNAGSMRSLN--------------- RFSREFVDTGERGKT-LREKMNLHNNEAGR------M--------HVQTEMRQECKCHGMSGSCTVKTCWMRLPSFRSVGDALKDRFDGASRVMMPNTEVEAPVQ--------------- RFSREFVDTGERGKT-LREKMNLHNNEAGR------A--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRSVGDALKDRFDGASRVLMSNSDVETPVL--------------- RFSREFVDTGERGKT-LREKMNLHNNEAGR------R--------HVQTEMKQECKCHGMSGSCTVKTCWMRLPSFRSVGDSLKDRFDGASRVMLSKADVETPAQ--------------- RFSREFVDTGERGKT-LREKMNLHNNEAGR------A--------HVQTEMKQECKCHGMSGSCTVKTCWMRLPSFRSVGDSLKDRFDGASRVMLSKAELETPAQ--------------- KFSRDFVDTGERGRT-LREKMNLHNNEAGR------L--------HVREEMRKECKCHGMSGSCTVKTCWMRLPHFRVVGDNLKDRFDGASRVLVGNAGSPRGPG--------------- TVSREFVDAGERGKT-IREKMNLHNNEAGR------W--------HVKDQMRQECKCHGMSGSCTIKTCWMRLPPFRVIGDLLKDRFDGASHVAASGHHRNNNNA--------------- KFSREFVDAGEKGRD-IRYMMNLHNNEAGR------V--------HVSTEMRQECKCHGMSGSCTVRTCWMRLPFFRVVGDNLKDRFDGASRVLISNTGRTPGNG--------------- KFARAFVDAAERGRD-LRFVINLHNNEAGR------L--------QVTTETRRECKCHGMSGSCTVKTCWMRLPSFRDVGNQLKERFDGASKVLVSNQGNFRGFR--------------- KFSRQFVDASERGKD-LRYIMNLHNNEAGR------A--------HVIGGMRRQCKCHGMSGSCTVQTCWMQLSPFRTIGDGLKDRFDGASRVLVTNRGNVR------------------ KFTKQFVGAAERGKD-LRFTMNLHNNEAGR------T--------HVAAGMRRQCKCHGMSGSCTVQTCWMQLPPFRAVGDGLKDRFDGASRVLVTNRGNVR------------------ KFSRMFVDTGERGRS-LREKMNLHNNEAGR------M--------HVQSEMKQECKCHGMSGSCTVKTCWMRLPIFRSIGDNLKDRFDGASRVMVGNAGGLRRMRSDDNTPNSHYEQ--- KFSREFVDTGERGRS-LREKMNLHNNEAGR------A--------HVSAEMRQECKCHGMSGSCTVKTCWMRLPNFRAVGDNLKDRFDGASRVMVSNAGSLRGNVAAL-----SNSA--- KFAQDFVDAAEKGRD-LKYMINLHNNEAGR------V--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPLFRSVGDILKDRFDGASRVLVGNRGNNRGSR--------------- VFGREFVDSSERGRD-LRYLMNLHNNEAGR------V--------TVFSEMRQECKCHGMSGSCTVKTCWMRLPTFRSIGDFLKDRFDGASRVIYGNKGSNRAS---------------- MFGREFVDSSERGRD-LRYLTNLHNNEAGR------M--------TVASEMQQECKCHGMSGSCTVRTCWMRLPSFRLVGDYLKDRFDGASRVVYANKGSNRAS---------------- LFGREFVDSGEKGRD-LRFLMNLHNNEAGR------T--------TVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRAS---------------- FIGREFVDSSERGRD-LKYLVNLHNNQAGR------L--------TVLTEMRQECKCHGMSGSCSLRTCWMRLPPFRSVGDALKDRFDGASKVTYSNNGSNRWG---------------- NFSRKFVDAGEKGRD-LRYYMNKHNNAAGR------R--------IVTDNMRRECKCHGMSGSCQVKTCWMRLPTFREVGDILKERFDGASQIAQTNNGHNRGTR--------------- RFGKKFVDSGEKGRD-LRHAMNLHNNEAGR------K--------TVSSEMRRECKCHGMSGSCTIETCWMRLPTFRTVGELIKERFDGASRVTMRNDGSPS------------------ KFGRRFVDVVEKGQD-IRYMMNLHNNAAGR------V--------HVTSQMTQACKCHGMSGSCQIKTCWMKLPTFRRVGDLLKDRFDGASRVLPGNAGSDRRRRRKF------------ KFSREFVDTGERGRT-LREKMNLHNNEAGR------A--------HVQAEMRQECKCHGMSGSCTMKTCWMRLNSFRTIGDILKDRFDGASRVMVSNSLLRNGGGGGGGGGGGGGGGGGG QFAKQFVDAGEKTKDSVRYLVNMHNNEAGR------V--------AVAENLRRECKCHGMSGSCTLKTCWMRLPNFRDVGDSLKEKFDGASKVAFPDIGNNRGSR--------------- RFSRHFVDAGEKTHE-IRAAMNLHNNEAGR------Q--------HVRAAMRSECKCHGMSGSCTVKTCWSRLPHFKQIGDRLKEKFDGASRVMSRHTAHMQRRSNSR------------ *oo oo * *** *** * ********** o *** * o o*o oo o****o o 481 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ NS-------VSSNGLIIPQSGLVYGEEEERMLNDHMPD-ILLENSHPISKIHHPNMPSPNSLPQ-AGQRGGR---NGR------------RQGRK------------------------- NS-------VGSNGLIIPQSGLVYGEEEERMLNDHMPD-ILLENSHPISKIHHPNMPSPNSLPQ-AGQRGGR---NGR------------RQGRK------------------------- NT-------AGPNAL-MPQS-VVYGEEEERMLNDHMPDSLLLENSHPS---------KSNSLPQ-AGQ-PNR---NGH------------RRGRK------------------------- NS------NGGSNGL-LQSA-VSVYEEEERMLNDHMPD-LLLDNTHLSSKIHHPNMPSPNSLPM-AGA-RSR---NGR------------RQGRK------------------------- NSVVVAGVGVGGNG--LPPS-VSGYDDEERMLNDHMPE-LLLDNSHPNSKQHHPNMPSPNSLPV-AGA-RSRG--HGR-----------GRLGRK------------------------- NS-VVGGVSGGGNG--LPAS-VSGYDDEERMLNDHMPE-LLLDNSHPNGKQHHPNMPSPNSLPV-AGA-RARG--HGR-----------GRQGRK------------------------- NG-VVGGVSNGGNG--LPPS-VNGYDDEERMLNDHIPE-LLLDNNHPNSKQHHPNMPSPNSLPV-AGA-RSRG--HGR-----------GRQGRK------------------------- ---------GSSSSVISPNAASPNAYDEDRMLNDE------------HVVKHHPNMPSPNSLPTSSNA-VSRNSVRGR-----------QRQGKK------------------------- ---------G-SAAVISPNAASPNAYDEDRMLNDE------------HVVKHHPNMPSPNSLPT-SNA-VSRNSVRGR-----------QRQGKK------------------------- ---------G-PTNGVLPNVASSNGYEDDRMLNDE------------HVLKHHPNMPSPNSLPN-PNS-ASRNSVRGR-----------QRQGKK------------------------- NGLKS-PNQVGSS----PNS-------------------------------------------------VSSNSIHAR-----------SHQQKK------------------------- NGLKA-QNQLGGSSPGGPNS-------------------------------------------------VSSNSIHAR-----------SHQQKKINRSF-----GDFQRWTKFLSKIFE ANLKTNANSVGGSA--SPNS-------------------------------------------------VLSNSIHAR-----------GHQQKRASERSLISLKTIHQYLTCFVSPLFF -----------------------------------------------------------------------SNSVHQH-----------RDGLGR------------------------- -----------------------------------------------------------------------SNSVHQH-----------REGLGR------------------------- -----------------------------------------------------------------------SNSVHQH-----------RDGLGR------------------------- -----------------------------------------------------------------------SNSVHQH-----------REGLGR------------------------- -----------------------------------------------------------------------SNSVHGH-----------REGLGR------------------------- -----------------------------------------------------------------------SNSVHGH-----------RDGLGR------------------------- -----------------------------------------------------------------------SNSVHGH-----------REGLGR------------------------- -----------------------------------------------------------------------SNSVHGH-----------REGLGR------------------------- -------------------------------------------------------------------------------------------GLGR------------------------- -----------------------------------------------------------------------SNSVHAH-----------REGLSR------------------------- -----------------------------------------------------------------------SNSVHQH-----------RDGLAR------------------------- -----------------------------------------------------------------------ANSVHQH-----------RDGLSR------------------------- ------------------------------------------------------------------------------------------SGRKK------------------------- -----------------------------------------------------------------------RNDAAPH-----------R--VPR------------------------- -----------------------------------------------------------------------RNDPGAH-----------R--VPR------------------------- -----------------------------------------------------------------------RNEAAPH-----------R--VPR------------------------- -----------------------------------------------------------------------RNEAAPH-----------R--VPR------------------------- ------------------------------------------------------------------------------------------AGKGK------------------------- ----------------------------------------------------HQNRPPKNPKLNA----ISSNSIHSK-----------RE-NRR------------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------SRRRK------------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------EQQQEQPQDQLTQQQPQQNGGGGGVRGR----------GRRRGGG------------------------- -----------------------------------------------------SSGPVSNNPSPRGRNSRTHNSAHHRSHSLLQFSATGGNIGGK------------------------- ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ GAGAAGGAGGGAGGGLGGPGGINEHTLTNRAGSSSSSNGGGNGNGNGNGNGGPKNGLGGNGGGSIANNNVLSNSIHAR--------GPGHAHQKR------------------------- ------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------RRSIKR------------------------- 601 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+........ ooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo ----HNRYHFQLNPHNPEHKPPGSKDLVYLEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL ----HNRYHFQLNPHNPEHKPPGSKDLVYLEPSPSFCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL ----HNRYSFQLNPHNPEHKPPGSKDLVYLEPSPSFCEKNLRHGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL ----HNRYHFQLNPHNPEHKPPGSKDIVYLEPSPSFCEKNLRHGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVIVVERCACTFHWCCEVKCKLCRTKKVIYTCL ----HNRYHFQLNPHNPEHKPPGPKDIVYLESSPSFCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL ----HNRYHFQLNPHNPEHKPPGPKDIVYLEPSPSFCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL ----HNRYHFQLNPHNPEHKPPGPKDIVYLEPSPSFCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL ----NNRYSFQLKPHNPDHKPPGTKDIVYLEPSPSFCEKNLRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKTIHTCL ----NNRYSFQLKPHNPDHKPPGTKDIVYLEPSPSFCEKNLRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKTIHTCL ----NNRYSFQLKPHNPDHKPPGTKDIVYLEPSPPFCEKNLRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKTIHTCL ----INRYNFQLKPHNPDHKPPGMKDLVYLEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVIVVERCACTFHWCCEVKCKLCRTKKIIHTCL FPSSINRYNFQLKPHNPDHKPPGTKDLVYLEPSPGFCDRNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVIVVERCACTFHWCCEVKCKLCRTKKIIHTCL LC--SRRYNFQLKPYNPEHKPPGSKDLVYLEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVTVVERCSCTFHWCCEVKCKLCRAKKIIHTCL ----RQRYNFQLKPYNPEHKPPGQKDLVYVEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCTFHWCCEVKCQLCRTKKTVHTCL ----RQRYNFQLKPYNPEHKPPGQKDLVYVEPSPPFCEKNPKLGILGTYGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCT---------------------- ----RHRYNFQLKPYNPEHKPPGQKDLVYVEPSPPFCEKNPKLGILGTQGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCT---------------------- ----RHRYNFQLKPYNPEHKPPGQKDLVYVEQSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEVTV----------------------------- ----RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCRIKKTIHTCL ----RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCRIKKTIHTCL ----RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCKIKKTIHTCL ----RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCKIKKTIHTCL ----RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCRIKKTIHTCL ----RHRYNFQLKPYNPEHKPPGVKDLVYLEPSPPFCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEIIVVERCNCTFHWCCEVKCQLCRTKKTIHTCL ----RQRYNFQLKPYNPEHKPPGPKDLVYLEQSPAFCEKNPALGILGTHGRQCNDTSLGVDGCDLMCCGRGYKTQEVVVIERCNCI---------------------- ----RQRYNLQLKPYNPEHKPPGPKDLVYLEQSPAFCEKNPKLGILGTHGRQCNETSLGVDGCDLMCCGRGYKTQEMVVIERCACIFHWCCEVKCQKCRTTKTVHTCL ----RNKYNLQLKPYDPDHKPPGTKDLVYLDPSPDFCERNPKLGIQGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEMMVTERCRCTFHWCCEVKCDYCRTKKTVHTCL ----RDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCEKNPRLGIPGTHGRTCNDTSIGVDGCDLMCCGRGYRTETMFVVERCNCTFHWCCDVKCKLCRTEKVVHTCL ----RDRYRFQLRPYNPDHKAPGAKDLVYLESSPGFCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTETKFVVERCN------------------------ ----KDRYRFQLRPHNPDHKSPGVKDLVYLESSPGFCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTNTMFVVERCNCTFHWCCEVKCKLCRTEKVVHTCL ----KDRYRFQLRPHNPDHKSPGVKDLVYLESSPGFCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTNTMFVVERCNCTFHWCCEVKCKLCRTEKVVHTCL ----GNRYNFQLQPYDAQHKPPGRKDLVYLDQSPNFCERNPRQGIQGTHGRECNETSLGLDGCDLMCCGRGHRSQEVMLVERCHCTFHWCCEVKCKTCHVRKTIHTCQ ----KHKYGFQLKPFNPEHKPPGTKDLVYYEMSPGFCEKNPKLGIQGTHGRLCNDTSMGVDGCDIMCCGRGYRTQEVVVFERCNCTFHWCCEVKCDVCRTKRTIHTCV ----RKKYNYQLKPYNPEHKAPSKKDLVYYENSPNFCEKNLKLGIAGTQGRVCNETSIGVDGCDLMCCGRGYKTEVKEVVERCACTFHWCCEVKCKVCRTKKTIHTCL ----GHARSFQLKPLYPDHKPPTRKDLVYFENSPDFCVPNSRLGVQGTRGRHCNESSPGVDGCESMCCGRGHRTEVREDLERCACTFHWCCQVKCKVCKIRRTVHTCL -------RRALLKPYHPEHKPPSKKDLVYFENSPDFCYADPSLGHSATLGRTCNVSSLGVDGCDLMCCGRGYKSENREEVSRCNCTFHWCCQVECKTCKTKRLVHECL -------RRALFKPYHPEHKPPSKKDLVYFENSPDFCFPDSNLGHRGTLGRICNASSIGVDGCDLMCCGRGHKAEHREETSRCNCTFHWCCQVECRTCKTRRLVHSCL ----RNRYNFQLKPYDPDLKAPGTKDLVYLETSPGFCDPNPRLGVLGTHGRQCNETSLGLDGCDLMCCGRGHKTHQALVSERCNCTFLWCCEVKCSVCQYRKTVNTCQ ----SGKYNFQLKPYNPEHKSPSVKDLVYFEPSPSFCDRNPRLGIAGTQGRKCNESSIGVDGCDLMCCGRGYKTEEITVRERCECTFHWCCE---------------- ------SKAFELEPYNPDHKPPTNKDLVYFENSPDFCEYNPLVGSLGTTGRTCNDTSIGVDGCDLMCCGRGYKSEEIEEEERCSCTFHWCC----------------- -----RADILHLEPENPAHKPPLPRDLVYFEKSPNFCTYNGKTGTLGTAGRYCNSSSPALDGCELLCCGRGYRTRTEKVTERCNCTFHWCCHVSCLNCTNTQVLHECL ----HRADPRHLEPENPAHKLPSSRDLVYFEKSPNFCSYNGKTGTHGTSGRTCNSSSPALDGCELLCCGRGYKTRMEQVTERCHCTFHWCCHVSCLNCTSTQTVHQCL -----RAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL ----SRSDPPHLEPENPTHALPSSQDLVYFEKSPNFCSASEKNGTPGTTGRICNSTSLGLDGCELLCCGRGYRSRAEKVTERCHCTFHWCCHVTCLNCTSSQIVHECL ----RKKRIKHFESADPQHKHPTASDLVYFEESPDFCELNKKVGSLGTRGRQCNNTSIGIDGCDLLCCERGYRSEIEQVTERCSCTFHWCCQVKCETCVTQRTVHTCL ----DRETESSFVPYNPSHKQPASRDLVYFENSPDFCERNDKFGTPGTRGRECNATSLGVDGCDLMCCSRGSTTTEIKVKERCSCTFHWCCKVKCEECTSFRTVHRCL ----TFTPKFTFTPFDPNHKAPSKKDLVYFEKSPEFCNQNNNIGFKGTVGRECNDTSLGLEGCDLMCCGRGHKTQTYMVVERCNCTFRWCCEVMCEACRITKMKHTCL ----INRYNFQLKPYNPEHKPPGAKDLVYLEPSPGFCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVTVVERCACTFHWCCEVKCKLCRTKKTIHTCL ------AKVTGLVPKNSRHKFPTDNDLVYHERSPNFCRNNPRLGFEGTRGRECNVTSRGLDGCDLLCCGRGYATRQEVTKERCNCTFQWCCQVKCEECVRTKTIHTCL ----KRRKNLDLQPYNPDHKSPSAMDLVYLQESPNFCVRNRTLGIPGTSERECNGTSIGVEGCNLMCCGRGYSSRVVEVVERCSC----------------------I o o * *o** o ** ** * o* * ** o* ooo** o** **