1. =_numo_s_00000001_numo_e_gi|195338887|ref|XP_002036055.1| GM16366 [Drosophila se 2. =_numo_s_00000002_numo_e_gi|21711721|gb|AAM75051.1| RE02607p [Drosophila melanog 3. =_numo_s_00000003_numo_e_gi|194762235|ref|XP_001963260.1| wingless [Drosophila a 4. =_numo_s_00000004_numo_e_gi|195147122|ref|XP_002014529.1| GL18899 [Drosophila pe 5. =_numo_s_00000005_numo_e_gi|195117368|ref|XP_002003219.1| GI23655 [Drosophila mo 6. =_numo_s_00000006_numo_e_gi|195387788|ref|XP_002052574.1| wg [Drosophila virilis 7. =_numo_s_00000007_numo_e_gi|195052361|ref|XP_001993287.1| GH13724 [Drosophila gr 8. =_numo_s_00000008_numo_e_gi|60393086|gb|AAX19493.1| wingless [Lucilia sericata] 9. =_numo_s_00000010_numo_e_gi|253735641|dbj|BAH84842.1| wingless protein [Sarcopha 10. =_numo_s_00000011_numo_e_gi|170040118|ref|XP_001847858.1| wingless protein [Cule 11. =_numo_s_00000012_numo_e_gi|157127174|ref|XP_001661069.1| wingless [Aedes aegypt 12. =_numo_s_00000013_numo_e_gi|157013971|gb|EAL39184.3| AGAP009734-PA [Anopheles ga 13. =_numo_s_00000014_numo_e_ATTCE|ACEP_00006907-PA pep:known scaffold:Attacep1.0:sc 14. =_numo_s_00000015_numo_e_gi|21103973|gb|AAM33135.1| wingless [Pheidole morrisi] 15. =_numo_s_00000016_numo_e_gi|21103975|gb|AAM33136.1| wingless [Crematogaster line 16. =_numo_s_00000017_numo_e_gi|21103979|gb|AAM33137.1| wingless [Myrmica americana] 17. =_numo_s_00000018_numo_e_gi|340709126|ref|XP_003393164.1| PREDICTED: protein Wnt 18. =_numo_s_00000019_numo_e_gi|383864839|ref|XP_003707885.1| PREDICTED: protein Wnt 19. =_numo_s_00000020_numo_e_gi|380014047|ref|XP_003691055.1| PREDICTED: protein Wnt 20. =_numo_s_00000021_numo_e_gi|328792342|ref|XP_003251712.1| PREDICTED: protein Wnt 21. =_numo_s_00000023_numo_e_gi|345486197|ref|XP_001603388.2| PREDICTED: protein Wnt 22. =_numo_s_00000024_numo_e_gi|21103977|gb|AAM33138.1| wingless [Formica nitidivent 23. =_numo_s_00000025_numo_e_gi|307188089|gb|EFN72921.1| Protein Wnt-1 [Camponotus f 24. =_numo_s_00000030_numo_e_gi|242007977|ref|XP_002424791.1| protein wingless precu 25. =_numo_s_00000026_numo_e_gi|357615448|gb|EHJ69660.1| protein Wnt-1 precursor [Da 26. =_numo_s_00000027_numo_e_gi|389614525|dbj|BAM20310.1| wingless, partial [Papilio 27. =_numo_s_00000028_numo_e_gi|500860|dbj|BAA03211.1| Bm. Wnt-1 [Bombyx mori] 28. =_numo_s_00000029_numo_e_BOMMO|BGIBMGA006146-TA pep:known scaffold:Bmor1:nscaf28 29. =_numo_s_00000031_numo_e_gi|11907531|dbj|BAB19660.1| wingless protein [Gryllus b 30. =_numo_s_00000032_numo_e_gi|270008212|gb|EFA04660.1| wingless [Tribolium castane 31. =_numo_s_00000033_numo_e_gi|294610352|dbj|BAJ05334.1| wingless protein [Daphnia 32. =_numo_s_00000035_numo_e_gi|241620045|ref|XP_002407192.1| WNT-2 precursor, putat 33. =_numo_s_00000036_numo_e_gi|19171515|emb|CAC87040.1| wingless [Cupiennius salei] 34. =_numo_s_00000037_numo_e_gi|45544551|dbj|BAD12586.1| Wingless [Achaearanea tepid 35. =_numo_s_00000034_numo_e_gi|193712553|ref|XP_001945295.1| PREDICTED: protein Wnt 36. =_numo_s_00000049_numo_e_gi|17226368|gb|AAL37756.1|AF438206_1 signaling protein 1 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ --------------------------------------------------------------------------------MDISYI---FVICL-MALCSGGSSLSQVE-GKQKSGRGRG --------------------------------------------------------------------------------MDISYI---FVICL-MALCSGGSSLSQVE-GKQKSGRGRG --------------------------------------------------------------------------------MDISYI---FVICL-MALFSSDSSIVPVE-GKQKSGRGRG --------------------------------------------------------------------------------MDISYI---FVISLMLALCS-----SQAE-SKQKSGRGRG --------------------------------------------------------------------------------MDLSYI---FIVCL-LALYS-----ADAE-SKQKSGRGRG --------------------------------------------------------------------------------MDLSYI---FIVCL-LALCS-----ADAE-SKQKSGRGRG --------------------------------------------------------------------------------MDLSYM---FIVCL-LALCS-----ADAE-SKQKSGRGRG --------------------------------------------------------------------------------MDLFTI---LRLLTVLLASL---ALTKAE-AKHKPGRGRG --------------------------------------------------------------------------------MDLLRI---LRLLTILMISL---TFTKAE-AKHKPGRGRG --------------------------------------------------------------------------------MELVTL---FLVCL-MAVSS---TSAEVE-SKSKPGRGRG ------------------------------------------------------------------------------------------MIFLPLLFHR-------------------- --------------------------------------------------------------------------------MNLVTV---FMVCL-MAISA----WAEVE-SKSKPGRGRG -------------------------------------------------------------------------------MHTMCIL---TLVSR-IYDRD---YAPPER-STTYCWSNTA ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------MVFHRSTKLDQNRDRIYAPRLHLIAKKNKKKMRLW---MIIGA-LAVAT---HASIAE-ITRNKNRGRG ----------------------------------------------------------------------------------MRLW---VIIGA-LVVAI---HASIAE-ITRNKNRGRG -------------------------------------------------------------------------MIAFDRQQKMRVW---VVICA-LVVAI---HASIAE-MPRNKNRGRG --------------------------------------------------------------------MHTTPMIAFDRQQKMRLW---VIICA-LVVAI---HASIAE-MPRNKNRGRG ----------------------------------------------------------------------------------MRLW---MMLGA-LAVAV---PTLPAE-VRTNKNRGRG ------------------------------------------------------------------------------------------------------------------------ ----------------------------------------------------------------------------------MRLW---MLLAV-LSVTA---YVSLAE-ITKNKNRGRG ------------------------------------------------------------------------------------------------------------------------ -----------------------------------------------------------------------------------------------MC--------LRCE-AANKPRRGRG --------------------------------------------------------------------------------MKCLWL---FVLTV-LC--------TRCE-AANKPRRGRG --------------------------------------------------------------------------------MKCLWL---LVITV-LC--------LRCDTAGTKPRRGRG ------------------------------------------------------------------------------------------------------------------------ --------------------------------------------------------------------------------MRAAAA---IPLLLLMALAG---LAARAA-TRAKMSRGRG MAGTASERFVLRRVLALLLASEAELGGVHFHVSRTTRAPQCKAQCHKELCCGWSEQKLTPPKSDTGDIVYFLRSCVRVDTMKVTVI---FVMNL-FVLTA---L-GDVT-NARSKNRGKG -----------------------------------------------------------------------------MSSMRTTVV---FVLVL-MMVLP---Y------LGTAKGRGRG ------------------------------------------------------------------------------------------------------------------------ ---------------------------------------------------------------------------MIFCSVRAALL---FILVV-TLLIP---AQ-----AKPRHRGQRG -----------------------------------------------------------------------------------------------------------------------G --------------------------------------------------------------------------------MKTTIVIKTIVLMT-LVVDG---I-SRAY-AKHREGKYKG -----------------------------------------------------------------------------MPAPKGAAF---VLIAA-LACAFV---------CEAQARKYKG 121 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooooooooooooooo ooooooooooooooooooooo oooooooooooo SMWWGIAKVGEPNNITP---------IMYMD-PAIHSTLRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTR--NFSRGKNLFGKIVDR--------------------- SMWWGIAKVGEPNNITP---------IMYMD-PAIHSTLRRKQRRLVRDNPGVLGALVKGANLAISKCQHQFRNRRWNCSTR--NFSRGKNLFGKIVDR--------------------- SMWWGIAKVGEPNNITP---------IMYMD-PAIHSTLRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTK--TISRGKNLFGKIVDR--------------------- SMWWGIAKVGEPNNMSP-----ITTGIMYMD-PAIHSTLRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTR--NFLRGKNLFGKIVDR--------------------- SMWWGIAKVGEPNNISP-----ISTSIMYMD-PAIHSTLRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTR--NFLRGKNLFGKIVDR--------------------- SMWWGIAKVGEPNNISP-----ISTGIMYMD-PAIHSTLRRKQRRLVRDNPGVLGALVKGANMAISECQHQFRNRRWNCSTR--NFLRGKNLFGKIVDR--------------------- SMWWGIAKVGEPNNISP-----ISTGIMYMD-PAIHSTLRRKQRRLVRDNPGVLGALVKGANMAISECQHQFRNRRWNCSTR--NFLRGKNLFGKIVDR--------------------- SMWWGIAKVGEPNNISP-----ISSGIMYVD-PAIHTTLRRKQRHLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTR--NFLRGKNLFGKIVDR--------------------- SMWWGIAKVGEPNNISP-----ISSGIMYVD-PAIHTTLRRKQRRLVRDNPGVLGALVKGANLAISECQHQFRNRRWNCSTR--NFLRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNNISP-----LANGMIYMD-PAIHATLRRKQRRLARENPGVLAAIAKGANMAINECQHQFRNRRWNCSTR--NFLRGKNLFGKIVER--------------------- ----GIAKAGEPNNISP-----LANGMIYMD-PAIHATLRRKQRRLARENPGVLAAIAKGANMAINECQHQFRNRRWNCSTR--NFLRGKNLFGKIVER--------------------- SMWWGIAKAGEPNNISP-----LAPGMAYLD-PAIHATLRRKQRRLARENPGVLAAIAKGANLAINECQHQFRTRRWNCSTR--NFLRGKNLFGKIVER--------------------- GSREGIAKAGEPNNFLP-----MSAGSIHME-P-VYATLRRKQRRLARENPGVLMSVSRGANQAIAECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDR--------------------- --------AGEPNNFLP-----MSAGSIHME-P-VYATLRRKQRRLARENPGVLMAVSRGANQAIAECQYQFRNRRWNCSTK--NFLKGKNLFGKIVDR--------------------- --------AGEPNNFLP-----MSASSIHME-R-FYATLRRKQRRLAIENPGVLMAVSRGANQAIAECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDR--------------------- --------AGEPNNFLP-----MSAASIHME-P-IYTTLRRKQRKLARDNPGVLMAVARGANQAITECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNNFLP-----MSPASLHMD-PTVYATLRRKQRRLARENPGVLMAVARGANQAIAECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNNFLP-----MSPASLHMD-PTVYATLRRKQRKLARENPGVLMAVARGANQAIAECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNNFLP-----MSPASLHMD-PTVYATLRRKQRRLARENPGVLMAVARGANQAIAECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNNFLP-----MSPASLHMD-PTVYATLRRKQRRLARENPGVLMAVARGANQAIAECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNNLLP-----MPATSLHMD-PSVYATLRRKQRRLARENPGVLMAVARGANQAISECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDR--------------------- --------ADEPNNFLP-----VSPTSL-MD-SSVYATLRRKQRRLVRENPGVLQAVARGANQAVAECQHQFRNRRWNCSTK--NFLRGKNLFGKIVDK--------------------- SMWWGIAKADEPNNFLP-----VSPTSM-LD-SSVYGNLRRKQKKLIRDNPGVLQAISRGANQAVAECQYQFRNRRWNCSTK--NFLRGKNLFGKIVDK--------------------- ----------------------MSPGVLSMD-PSVHQTLRRKQRRLARENPGVLVAVAKGANQAILECQYQFRDRRWNCSTR--NFLRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNTLSP-----LSPGVLYMD-PAVHATLRRKQRRLARENPGVLAAVAKGASMAVAECQHQFKYRRWNCSTR--NFLRGKNMFGKIVDR--------------------- SMWWGIAKAGEPNNISP-----MSPGVLYMD-AGVHSTLRRKQRRLAKENPGVLTAVAKGANMAVAECQHQFKYRRWNCTTR--NFLRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNNLSP-----VSPGVLFMD-PAVHATLRRKQRRLARENPGVLAAVAK-AQYAFAECQHQFKYRRWNCSTR--NFLRGKNLFGKIVDR--------------------- ----GIAKAGEPNNLSP-----VSPGVLFMD-PAVHATLRRKQRRLARENPGVLAAVAKGASMAVAECQHQFKYRRWNCSTR--NFLRGKNLFGKIVDRENRSILIVEVQKSLNRYLEEV SKWWGIAKAGEPNNLLP-----LAPGELYMD-PAVHATLRRKQRRLVRDHPGVLLAVVKGANQAIGECQFQFRNRRWNCSTK--NFFRGKNLFGKIVDR--------------------- SMWWGIAKAGEPNNLSP-----ISPGGVYMDLSSAHGTLRRKQRRLARENPGLLVALHKGANNAIHECQHQFRNQRWNCSTR--AFPRGKNLFGKIVDK--------------------- SKWWGIARAGEPNNLVSNSIKENSITNSYLD-PDVHATLRRKQRRLVRDHPGVVVAVAKGAKQAISECKHQFKNRRWNCPTK--DFHRGRNLFGKIVDR--------------------- -----------------------------------SVPLRRKQRGLVRANPGSLQAIGRGMRLAISECKHQFRDRRWNCPTP--EYMRGKSLFGKIVHR--------------------- SRWWSLAFSEEPTNLVVDFH--RGNSMNDRG-PAPHLPLRKKQRRLVRDNPGAMQAIGRGVKVAISECKYQFKKRRWNCPTA--DHARGKNIFGKIVQR--------------------- SRWWNIAYSEEISNFVVDFH--RTNTLVGRG-FAPHTLLRKKQRRLVRENPGAMTAIGRGVRLSISECKHQFKKRRWNCPTI--DYTRGRNIFGKIVQK--------------------- THWWGIAKAGEPNNLAP-----MTPGLMLMD-SSSLTLLRNKQRRLIREHPGVLQAISRGVNMALQECQHQFRNRRWNCSTK--NFLTGKNLFGKIVDR--------------------- PKWWNLGLSVDPSNLMSNEILSNSLSDHHLS-ESVQRMLRKKQRRLIRENDGVLVAIAEGAKKAAKSCRYQFRSRRWDCSASRKKKIKRRRLFGRIVSI--------------------- ** **o * * o oo o * **o **o*oo o o**o** 241 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooooooooooooooooooooooooooooooooooo oooooooooooooooooooooooooooooooooooooo -----------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETSFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQSRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETGFIYAITSAAVTHSIARACSEGTIESCTCDYSHQTRSP--------QANHQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETGFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRSP--------QANAQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETGFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRSP--------QANVQAGSVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRAP--------QAN-SMGAVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRTLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIESCTCDYSHQSRAP--------QAS-TMGAVAGVRDWEWGGCSDNIGFGFKFSREFVDTGERGRTLREKMNLHN -----------------GCRETAFIYAITSAAVTHSVARACSEGSIESCTCDYSHHNREP--------QMN-NMGVVAGVGDWEWGGCSDNIGFGFKFSRDFVDTGERGRTLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRVS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSHAS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQLCSCDYTHQSRAS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFVYAIASAAVTHSIARACSEGSIQSCSCDYTHQSRAS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------SGTRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGTIQSCSCDYTHQSRPP-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------SATRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRPP-----------------STTRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYSHQSRGP-----------------SGVRDWEWGGCSDNIGYGFRFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRTS-----------------SAVRDWEWGGCSDNIGYGFKFSREFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHSIARACSEGSIQSCSCDYTHQSRTS-----------------SAVRDWEWGGCSDNIGYGFTFSRDFVDTGERGRNLREKMNLHN -----------------GCRETAFIYAITSAAVTHAVARACSEGAIKSCTCDYSHQGRGPLPTRIAHHQARGPTNTLPGVRDWEWGGCSDNIGFGFKFSRAFVDTGEKGRNLREKMNLHN -----------------GCRETAFLYAITSAGVTHAVSRACAEGAIESCTCDYSHVDRAP--------HRS-RAATAANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKTLREKMNLHN -----------------GCRETAFIYAITSAGVTHAVSRACAEGSIESCTCDYSHLERTP--------HRT-RAAAAANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKTLREKMNLHN -----------------GCRETAFIYAITSAGVTHSLARACREASIESCTCDYSHRPRAA---------QN-PVGGRANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKTLREKMNLHN DAPAVPIVMIELIISRVGCRETAFIYAITSAGVTHSVARACAEGSIESCTCDYSHIDRVP--------HRT-RSAAAANVRVWKWGGCSDNIGFGFRFSREFVDTGERGKTLREKMNLHN -----------------GCRETAFIYAITSAGVTHAIARACAEGSIQSCTCDYRHAGRVA--------GGRGGGGGGGKKPDWEWGGCSDNIEYGFKFSRDFVDTGERGRTLREKMNLHN -----------------GCRETAFIYAITSAAVTHAIARACSEGSIDTCNCETHYKGRPH-------VSGNGGGAAVAGVRDFEWGGCSDNIGFGFTVSREFVDAGERGKTIREKMNLHN -----------------ACRETAFIYALMSAAVTHSVSRACSEGAIESCTCDYSQRGPSG--------------------ADWEWGGCSDNIQFGVKFSREFVDAGEKGRDIRYMMNLHN -----------------GCRETAFVYAITSAGVAHAVSRACSEGAIDTCTCDYRQRGPSG--------------------LDWEWGGCSDNVHFGYKFARAFVDAAERGRDLRFVINLHN -----------------GCRETAFLYAITSAGVTHSLSRACREGLVSTCNCDYRRRGPSG--------------------LHWEWGGCSDNIDFGAKFSRQFVDASERGKDLRYIMNLHN -----------------GCRETAFLYAITSAGVTHAMARACREGLVTSCSCDYKRRGPSG--------------------LDWEWGGCSDNIEFGSKFTKQFVGAAERGKDLRFTMNLHN -----------------GFRETAFIYAITSAGVTHAVSRACAEGVIETCTCDTTHQRRGP-----------YIQNSVPGVKDWEWGGCSDNIDFGYKFSRMFVDTGERGRSLREKMNLHN -----------------PCRETAFVYALLSAAVLHSVTRACTEGAVHSCSCHYTAKG-----------------------DDWEWGGCSENIDFGYRFSRHFVDAGEKTHEIRAAMNLHN o ***o*o**o **o* *ooo*** *o o * * o *****o*o o* oo ** oo*ooo o* o**** 361 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ ooooo oooooooooooooooooooooooooooooooooooooooooooooooooo NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNSLRATNALAPV----SPNAA-GSNS-------VSSNGLIIPQSGLVYG NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVTNSLRATNALAPV----SPNAA-GSNS-------VGSNGLIIPQSGLVYG NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVVGDNLKARFDGATRVQVNNHRSQNS--IPV---ISPNAV-GSNT-------AGPNAL-MPQS-VVYG NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSANAVAV---VSPNAAMGSNS------NGGSNGL-LQSA-VSVY NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVPV---VNPNAA-GPNSVVVAGVGVGGNG--LPPS-VSGY NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVAV---VSPNAA-GSNS-VVGGVSGGGNG--LPAS-VSGY NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKARFDGATRVQVSNSLRQSSNAVAV---ISPNAA-GSNG-VVGGVSNGGNG--LPPS-VNGY NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKDRFDGASRVMMSNSLRPSGSANAVGTANSPNAV------------GSSSSVISPNAASPNA NEAGR------A--------HVQAEMRQECKCHGMSGSCTVKTCWMRLANFRVIGDNLKDRFDGASRVMMSNSLRPSGSANAA-NAGSPNAV------------G-PTNGVLPNVASSNG NEAGR------S--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDLLKDRFDGASRVMVSNSLRTT-VNEAT----LSNRA-NPNGLKS-PNQVGSS----PNS----- NEAGR------A--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDLLKDRFDGASRVMVSNSLRTS-VNEAT----LSNRA-NPNGLKA-QNQLGGSSPGGPNS----- NEAGR------A--------HVQAEMRQECKCHGMSGSCTMKTCWMRLNSFRTIGDILKDRFDGASRVMVSNSLRSTSVNENT----LTNRA-GSANLKTNANSVGGSA--SPNS----- NEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRARVTNNAI----TSNSA---------------------------- NEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRARVNNNAI----TSNSA---------------------------- NEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRLVGDNLKDRFDGASRVMVSNSDRVRVSNNAI----TSNSA---------------------------- NEAGR------A--------HVTSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRVNNNAI----MSNSA---------------------------- NEAGR------A--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA---------------------------- NEAGR------A--------HVSSGMRQDCKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA---------------------------- NEAGR------A--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA---------------------------- NEAGRAVSFFFA--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPNFRVVGDNLKDRFDGASRVMVSNSDRVRGNGNAI----VSNSA---------------------------- NEAGR------T--------HVSAEMRQECKCHGMSGSCTVKTCWMRLPSFRQVGDNLKDRFDGASRVMVSNSDRARGVSNAI----TSNSA---------------------------- NEAGR------T--------HVSSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNSDRVRSNV-------HVNSA---------------------------- NEAGR------TGVVSVLLQHVSSEMRQECKCHGMSGSCTVKTCWMRLPSFRVVGDNLKDRFDGASRVMVSNSDRVRSNANL-------------------------------------- NEAGR------V--------HVSMGMRQECKCHGMSGSCTVKTCWMRLPTFREIGDSLKDRFDGASRVMLSNAGSMRSLN---------------------------------------- NEAGR------M--------HVQTEMRQECKCHGMSGSCTVKTCWMRLPSFRSVGDALKDRFDGASRVMMPNTEVEAPVQ---------------------------------------- NEAGR------A--------HVQSEMRQECKCHGMSGSCTVKTCWMRLPSFRSVGDALKDRFDGASRVLMSNSDVETPVL---------------------------------------- NEAGR------R--------HVQTEMKQECKCHGMSGSCTVKTCWMRLPSFRSVGDSLKDRFDGASRVMLSKADVETPAQ---------------------------------------- NEAGR------A--------HVQTEMKQECKCHGMSGSCTVKTCWMRLPSFRSVGDSLKDRFDGASRVMLSKAELETPAQ---------------------------------------- NEAGR------L--------HVREEMRKECKCHGMSGSCTVKTCWMRLPHFRVVGDNLKDRFDGASRVLVGNAGSPRGPG---------------------------------------- NEAGR------W--------HVKDQMRQECKCHGMSGSCTIKTCWMRLPPFRVIGDLLKDRFDGASHVAASGHHRNNNNA---------------------------------------- NEAGR------V--------HVSTEMRQECKCHGMSGSCTVRTCWMRLPFFRVVGDNLKDRFDGASRVLISNTGRTPGNG---------------------------------------- NEAGR------L--------QVTTETRRECKCHGMSGSCTVKTCWMRLPSFRDVGNQLKERFDGASKVLVSNQGNFRGFR---------------------------------------- NEAGR------A--------HVIGGMRRQCKCHGMSGSCTVQTCWMQLSPFRTIGDGLKDRFDGASRVLVTNRGNVR------------------------------------------- NEAGR------T--------HVAAGMRRQCKCHGMSGSCTVQTCWMQLPPFRAVGDGLKDRFDGASRVLVTNRGNVR------------------------------------------- NEAGR------M--------HVQSEMKQECKCHGMSGSCTVKTCWMRLPIFRSIGDNLKDRFDGASRVMVGNAGGLRRMRSDDNTPNSHYEQ---------------------------- NEAGR------Q--------HVRAAMRSECKCHGMSGSCTVKTCWSRLPHFKQIGDRLKEKFDGASRVMSRHTAHMQRRSNSR------------------------------------- ***** * o o***********o *** * *o o*o ** o****oo* 481 .........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+.........+ oooooooooooooooooooooooooooo EEEERMLNDHMPD-ILLENSHPISKIHHPNMPSPNSLPQ-AGQRGGR---NGR--RQGRK-----------------------------HNRYHFQLNPHNPEHKPPGSKDLVYLEPSPS EEEERMLNDHMPD-ILLENSHPISKIHHPNMPSPNSLPQ-AGQRGGR---NGR--RQGRK-----------------------------HNRYHFQLNPHNPEHKPPGSKDLVYLEPSPS EEEERMLNDHMPDSLLLENSHPS---------KSNSLPQ-AGQ-PNR---NGH--RRGRK-----------------------------HNRYSFQLNPHNPEHKPPGSKDLVYLEPSPS EEEERMLNDHMPD-LLLDNTHLSSKIHHPNMPSPNSLPM-AGA-RSR---NGR--RQGRK-----------------------------HNRYHFQLNPHNPEHKPPGSKDIVYLEPSPS DDEERMLNDHMPE-LLLDNSHPNSKQHHPNMPSPNSLPV-AGA-RSRG--HGR-GRLGRK-----------------------------HNRYHFQLNPHNPEHKPPGPKDIVYLESSPS DDEERMLNDHMPE-LLLDNSHPNGKQHHPNMPSPNSLPV-AGA-RARG--HGR-GRQGRK-----------------------------HNRYHFQLNPHNPEHKPPGPKDIVYLEPSPS DDEERMLNDHIPE-LLLDNNHPNSKQHHPNMPSPNSLPV-AGA-RSRG--HGR-GRQGRK-----------------------------HNRYHFQLNPHNPEHKPPGPKDIVYLEPSPS YDEDRMLNDE------------HVVKHHPNMPSPNSLPTSSNA-VSRNSVRGR-QRQGKK-----------------------------NNRYSFQLKPHNPDHKPPGTKDIVYLEPSPS YEDDRMLNDE------------HVLKHHPNMPSPNSLPN-PNS-ASRNSVRGR-QRQGKK-----------------------------NNRYSFQLKPHNPDHKPPGTKDIVYLEPSPP --------------------------------------------VSSNSIHAR-SHQQKK-----------------------------INRYNFQLKPHNPDHKPPGMKDLVYLEPSPG --------------------------------------------VSSNSIHAR-SHQQKKINRSF-----GDFQRWTKFLSKIFEFPSSINRYNFQLKPHNPDHKPPGTKDLVYLEPSPG --------------------------------------------VLSNSIHAR-GHQQKRASERSLISLKTIHQYLTCFVSPLFFLC--SRRYNFQLKPYNPEHKPPGSKDLVYLEPSPG ----------------------------------------------SNSVHQH-RDGLGR-----------------------------RQRYNFQLKPYNPEHKPPGQKDLVYVEPSPP ----------------------------------------------SNSVHQH-REGLGR-----------------------------RQRYNFQLKPYNPEHKPPGQKDLVYVEPSPP ----------------------------------------------SNSVHQH-RDGLGR-----------------------------RHRYNFQLKPYNPEHKPPGQKDLVYVEPSPP ----------------------------------------------SNSVHQH-REGLGR-----------------------------RHRYNFQLKPYNPEHKPPGQKDLVYVEQSPP ----------------------------------------------SNSVHGH-REGLGR-----------------------------RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPP ----------------------------------------------SNSVHGH-RDGLGR-----------------------------RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPP ----------------------------------------------SNSVHGH-REGLGR-----------------------------RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPP ----------------------------------------------SNSVHGH-REGLGR-----------------------------RHRYNFQLKPYNPEHKPPGPKDLVYLEPSPP ----------------------------------------------SNSVHAH-REGLSR-----------------------------RHRYNFQLKPYNPEHKPPGVKDLVYLEPSPP ----------------------------------------------SNSVHQH-RDGLAR-----------------------------RQRYNFQLKPYNPEHKPPGPKDLVYLEQSPA ----------------------------------------------ANSVHQH-RDGLSR-----------------------------RQRYNLQLKPYNPEHKPPGPKDLVYLEQSPA -------------------------------------------------------SGRKK-----------------------------RNKYNLQLKPYDPDHKPPGTKDLVYLDPSPD ----------------------------------------------RNDAAPH-R--VPR-----------------------------RDRYRFQLRPHNPDHKTPGVKDLVYLESSPG ----------------------------------------------RNDPGAH-R--VPR-----------------------------RDRYRFQLRPYNPDHKAPGAKDLVYLESSPG ----------------------------------------------RNEAAPH-R--VPR-----------------------------KDRYRFQLRPHNPDHKSPGVKDLVYLESSPG ----------------------------------------------RNEAAPH-R--VPR-----------------------------KDRYRFQLRPHNPDHKSPGVKDLVYLESSPG -------------------------------------------------------AGKGK-----------------------------GNRYNFQLQPYDAQHKPPGRKDLVYLDQSPN ---------------------------HQNRPPKNPKLNA----ISSNSIHSK-RE-NRR-----------------------------KHKYGFQLKPFNPEHKPPGTKDLVYYEMSPG -----------------------------------------------------------------------------------------RKKYNYQLKPYNPEHKAPSKKDLVYYENSPN -------------------------------------------------------SRRRK-----------------------------GHARSFQLKPLYPDHKPPTRKDLVYFENSPD --------------------------------------------------------------------------------------------RRALLKPYHPEHKPPSKKDLVYFENSPD --------------------------------------------------------------------------------------------RRALFKPYHPEHKPPSKKDLVYFENSPD -------------------------EQQQEQPQDQLTQQQPQQNGGGGGVRGRGRRRGGG-----------------------------RNRYNFQLKPYDPDLKAPGTKDLVYLETSPG ------------------------------------------------------RRSIKR-----------------------------KRRKNLDLQPYNPDHKSPSAMDLVYLQESPN * oo *o*o *o** o ** 601 .........+.........+.........+.........+.........+.........+.........+.........+. oooooooooooooooooooooooooooooooooooooooooooo FCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL-------- FCEKNLRQGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL-------- FCEKNLRHGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVVVVERCACTFHWCCEVKCKLCRTKKVIYTCL-------- FCEKNLRHGILGTHGRQCNETSLGVDGCGLMCCGRGYRRDEVIVVERCACTFHWCCEVKCKLCRTKKVIYTCL-------- FCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL-------- FCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL-------- FCEKNLRQGILGTHGRQCNDTSLGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKIIHTCL-------- FCEKNLRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKTIHTCL-------- FCEKNLRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVVVVERCACTFHWCCEVKCKLCRTKKTIHTCL-------- FCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVIVVERCACTFHWCCEVKCKLCRTKKIIHTCL-------- FCDRNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVIVVERCACTFHWCCEVKCKLCRTKKIIHTCL-------- FCERNPRLGIQGTHGRQCNDTSIGVDGCDLMCCGRGYRTQEVTVVERCSCTFHWCCEVKCKLCRAKKIIHTCL-------- FCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCTFHWCCEVKCQLCRTKKTVHTCL-------- FCEKNPKLGILGTYGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCT------------------------------ FCEKNPKLGILGTQGRQCNDTSIGVDGCDLMCCGRGHKTQEVTVIERCSCT------------------------------ FCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEVTV------------------------------------- FCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCRIKKTIHTCL-------- FCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCRIKKTIHTCL-------- FCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCKIKKTIHTCL-------- FCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEVTVVERCACTFHWCCEVKCQLCKIKKTIHTCL-------- FCEKNPKLGILGTHGRQCNDTSIGVDGCDLMCCGRGYKTQEIIVVERCNCTFHWCCEVKCQLCRTKKTIHTCL-------- FCEKNPALGILGTHGRQCNDTSLGVDGCDLMCCGRGYKTQEVVVIERCNCI------------------------------ FCEKNPKLGILGTHGRQCNETSLGVDGCDLMCCGRGYKTQEMVVIERCACIFHWCCEVKCQKCRTTKTVHTCL-------- FCERNPKLGIQGTHGRQCNDTSIGVDGCDLMCCGRGHKTQEMMVTERCRCTFHWCCEVKCDYCRTKKTVHTCL-------- FCEKNPRLGIPGTHGRTCNDTSIGVDGCDLMCCGRGYRTETMFVVERCNCTFHWCCDVKCKLCRTEKVVHTCL-------- FCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTETKFVVERCN-------------------------------- FCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTNTMFVVERCNCTFHWCCEVKCKLCRTEKVVHTCL-------- FCEKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYKTNTMFVVERCNCTFHWCCEVKCKLCRTEKVVHTCL-------- FCERNPRQGIQGTHGRECNETSLGLDGCDLMCCGRGHRSQEVMLVERCHCTFHWCCEVKCKTCHVRKTIHTCQ-------- FCEKNPKLGIQGTHGRLCNDTSMGVDGCDIMCCGRGYRTQEVVVFERCNCTFHWCCEVKCDVCRTKRTIHTCVKKKKKKKK FCEKNLKLGIAGTQGRVCNETSIGVDGCDLMCCGRGYKTEVKEVVERCACTFHWCCEVKCKVCRTKKTIHTCL-------- FCVPNSRLGVQGTRGRHCNESSPGVDGCESMCCGRGHRTEVREDLERCACTFHWCCQVKCKVCKIRRTVHTCL-------- FCYADPSLGHSATLGRTCNVSSLGVDGCDLMCCGRGYKSENREEVSRCNCTFHWCCQVECKTCKTKRLVHECL-------- FCFPDSNLGHRGTLGRICNASSIGVDGCDLMCCGRGHKAEHREETSRCNCTFHWCCQVECRTCKTRRLVHSCL-------- FCDPNPRLGVLGTHGRQCNETSLGLDGCDLMCCGRGHKTHQALVSERCNCTFLWCCEVKCSVCQYRKTVNTCQ-------- FCVRNRTLGIPGTSERECNGTSIGVEGCNLMCCGRGYSSRVVEVVERCSC----------------------I-------- ** o * o* * ** o* *oo** ******